Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Brian Henry"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Hannah Sirianni, Matthew J. Sirianni, David J. Mallinson, Niels L. Lindquist, Lexia M. Valdes-Weaver, Michael Moody, Brian Henry, Christopher Colli, Brian Rubino, Manuel Merello Peñalver, Carter Henne
Publikováno v:
Coasts, Vol 2, Iss 4, Pp 302-322 (2022)
Barrier islands within sheltered environments are an important natural defense from severe storm impacts for coastal communities worldwide. Despite their importance, these fetch-limited barrier islands remain understudied and their ability to withsta
Externí odkaz:
https://doaj.org/article/8dc2d48db2e542b1aa8b85d570afa3aa
Autor:
Simon Ng, Shuhui Lim, Adrian Chong Nyi Sim, Ruban Mangadu, Ally Lau, Chunsheng Zhang, Sarah Bollinger Martinez, Arun Chandramohan, U-Ming Lim, Samantha Shu Wen Ho, Shih Chieh Chang, Pooja Gopal, Lewis Z. Hong, Adam Schwaid, Aaron Zefrin Fernandis, Andrey Loboda, Cai Li, Uyen Phan, Brian Henry, Anthony W. Partridge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms un
Externí odkaz:
https://doaj.org/article/0fbf12d4ecc444c2912ab9c47b00b517
Autor:
Shuhui Lim, Regina Khoo, Yu-Chi Juang, Pooja Gopal, Huibin Zhang, Constance Yeo, Khong Ming Peh, Jinkai Teo, Simon Ng, Brian Henry, Anthony W. Partridge
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 274-291 (2020)
Externí odkaz:
https://doaj.org/article/5f5d414c219444a1a1f0c50dacdb5325
Publikováno v:
Frontiers in Psychiatry, Vol 7 (2016)
Schizophrenia has long been considered one of the most intractable of psychiatric conditions. Its etiology is likely polygenic, and its symptoms the result of complex network-level changes in neuronal activity. While easily identifiable by psychiatri
Externí odkaz:
https://doaj.org/article/cca7fb2ce0824a749e938f3495204447
Autor:
Abu Bakar Ali Asad, Stephanie Seah, Richard Baumgartner, Dai Feng, Andres Jensen, Elaine Manigbas, Brian Henry, Andrea Houghton, Jeffrey L Evelhoch, Stuart W G Derbyshire, Chih-Liang Chin
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156805 (2016)
BACKGROUND:Approximately 20% of the adult population suffer from chronic pain that is not adequately treated by current therapies, highlighting a great need for improved treatment options. To develop effective analgesics, experimental human and anima
Externí odkaz:
https://doaj.org/article/1cd4e24f8847447284baa7531914d4f1
Autor:
Stephanie Seah, Abu Bakar Ali Asad, Richard Baumgartner, Dai Feng, Donald S Williams, Elaine Manigbas, John D Beaver, Torsten Reese, Brian Henry, Jeffrey L Evelhoch, Chih-Liang Chin
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110432 (2014)
BACKGROUND: Pharmacological MRI (phMRI) is a neuroimaging technique where drug-induced hemodynamic responses can represent a pharmacodynamic biomarker to delineate underlying biological consequences of drug actions. In most preclinical studies, anima
Externí odkaz:
https://doaj.org/article/b64f07d05c404274a1dca2bd473850b4
Akademický článek
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Autor:
Simon Ng, Alexander C. Brueckner, Soheila Bahmanjah, Qiaolin Deng, Jennifer M. Johnston, Lan Ge, Ruchia Duggal, Bahanu Habulihaz, Benjamin Barlock, Sookhee Ha, Ahmad Sadruddin, Constance Yeo, Corey Strickland, Andrea Peier, Brian Henry, Edward C. Sherer, Anthony W. Partridge
Publikováno v:
Journal of Medicinal Chemistry. 65:9789-9801
STIP1 homology and U-Box containing protein 1 (STUB1) plays a key role in maintaining cell health during stress and aging. Recent evidence suggested STUB1 also helps regulate immunity with the potential of clearing malignant cells. Indeed, we and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d4ec6db56ddbda74bf2aedff793236
https://doi.org/10.1021/acs.jmedchem.2c00406
https://doi.org/10.1021/acs.jmedchem.2c00406
Autor:
Ferrero, María Eugenia, Villalba, Ricardo, De Membiela, Mónica, Ferri Hidalgo, Lidia, Luckman, Brian Henry
Publikováno v:
In Journal of Hydrology June 2015 525:572-584