Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Brian Harms"'
Autor:
Ashish Kalra, Jeffrey D. Kearns, Adnan O. Abu-Yousif, Gavin MacBeath, Alexey Lugovskoy, Maria Håkansson, Derek T. Logan, Birgit Schoeberl, Martin Welin, Melissa Geddie, Ulrik B. Nielsen, Neeraj Kohli, Tim Maiwald, Jessica B. Casaletto, Aaron Fulgham, Brian Harms, Shrikanta Chattopadhyay, Stephen Su, Maja Razlog, Antoine Boudot, Kristina Masson, Andreas Raue
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7533-7542
Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe611f4e29515cf93f14761355c252
https://doi.org/10.1073/pnas.1819085116
https://doi.org/10.1073/pnas.1819085116
Autor:
Jonathan Fitzgerald, Gavin MacBeath, Aaron Fulgham, Victor Moyo, Brian Harms, Emily Pace, Art Kudla, Gregory J. Finn, Viara P. Grantcharova, Jeff Kearns, Kristina Masson, Bambang Adiwijaya, Michael D. Curley, Gabriela Garcia, Ulrik B. Nielsen, Birgit Schoeberl, Bill Kubasek, Jaeyeon Kim, Olga Burenkova, Rachel Nering, Marisa Wainszelbaum, Sara Mathews, Ashish Kalra, Defne Yarar, Violette Paragas, Akos Czibere, Kip A. West
Publikováno v:
NPJ Systems Biology and Applications
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b645b897855719c9c27f8b7f814d0d6
https://doi.org/10.1038/npjsba.2016.34
https://doi.org/10.1038/npjsba.2016.34
Autor:
Victoria Rimkunas, Jian Tang, Alexey Lugovskoy, Rachel Rennard, Kenneth J. Olivier, Lihui Xu, Sergio Iadevaia, Birgit Schoeberl, Bryan Johnson, Jonathan Fitzgerald, Neeraj Kohli, Brian Harms, Jason Baum, Yang Jiao, Sharlene Adams, Ulrik B. Nielsen, Maja Razlog
Publikováno v:
Molecular Cancer Therapeutics. 13:410-425
Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor (EGFR)-driven cancers, the effectiveness of IGF-I receptor (IGF-IR) inhibitors in clinical trials has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070ac5deb4716e1e18ef496baf8ff8b8
https://doi.org/10.1158/1535-7163.mct-13-0255
https://doi.org/10.1158/1535-7163.mct-13-0255
Publikováno v:
Methods. 65:95-104
Antibodies are essential components of the adaptive immune system that provide protection from extracellular pathogens and aberrant cells in the host. Immunoglobulins G, which have been adapted for therapeutic use due to their exquisite specificity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a7addc49a919581957a8bea61ec494
https://doi.org/10.1016/j.ymeth.2013.07.017
https://doi.org/10.1016/j.ymeth.2013.07.017
Autor:
Violette Paragas, Matt Wallace, Stephanie Nguyen, Ryan Overland, Michael Feldhaus, Neeraj Kohli, Lia Luus, Brian Harms, Birgit Schoeberl, Bo Zhang, Aruthur J Kudla, Sharlene Adams, Ulrik B. Nielsen, Charlotte Mcdonagh, Shinji Oyama, Jinming Gu, Alexandra Huhalov
Publikováno v:
Molecular Cancer Therapeutics. 11:582-593
The prevalence of ErbB2 amplification in breast cancer has resulted in the heavy pursuit of ErbB2 as a therapeutic target. Although both the ErbB2 monoclonal antibody trastuzumab and ErbB1/ErbB2 dual kinase inhibitor lapatinib have met with success i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648bfc7fca06202d74d2520d4e983bab
https://doi.org/10.1158/1535-7163.mct-11-0820
https://doi.org/10.1158/1535-7163.mct-11-0820
Autor:
Ilse Y. Guzman-Jimenez, Joseph L. Stark, ‡ and Jean-François Halet, Jean-Yves Saillard, Brian Harms, Régis Gautier, Kenton H. Whitmire
Publikováno v:
Journal of the American Chemical Society. 121:4409-4418
Tetrakis(diphenylmethylphosphine)palladium reacts with diphenylantimony chloride or diphenylbismuth bromide to give [E4(PdL2)4][Ph2EX2]2 (L = PPh2Me, 1: E = Sb, X = Cl; 2: E = Bi, X = Br) which have been characterized spectroscopically and by single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a124a2075a9d1c3b924cf4e8924d2862
https://doi.org/10.1021/ja982902u
https://doi.org/10.1021/ja982902u
Autor:
Alexey Kamyshny, David T. Adams, John B. Cliff, James Farquhar, Brian Harms, Mark Claire, Aubrey L. Zerkle, Simon W. Poulton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(44)
It is generally thought that the sulfate reduction metabolism is ancient and would have been established well before the Neoarchean. It is puzzling, therefore, that the sulfur isotope record of the Neoarchean is characterized by a signal of atmospher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4782bf6837ddbc012b4b6e6366c83d
https://pubmed.ncbi.nlm.nih.gov/23407162
https://pubmed.ncbi.nlm.nih.gov/23407162
Autor:
Hao Zou, Ulrik B. Nielsen, Fraser Conrad, Yu Zhou, Brian Harms, Anne Laure Goenaga, Gregory P. Adams, Jianlong Lou, James D. Marks, Birgit Schoeberl
Publikováno v:
Molecular cancer therapeutics. 11(7)
Aberrant expression and activation of EGF receptor (EGFR) has been implicated in the development and progression of many human cancers. As such, targeted therapeutic inhibition of EGFR, for example by antibodies, is a promising anticancer strategy. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e22eaee6d9ab946019c09cf4f9a6f8
https://pubmed.ncbi.nlm.nih.gov/22564724
https://pubmed.ncbi.nlm.nih.gov/22564724
Monoclonal antibodies are valuable as anticancer therapeutics because of their ability to selectively bind tumor-associated target proteins like receptor tyrosine kinases. Kinetic computational models that capture protein–protein interactions using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd2a5108d5b5f948f6c8563bef8f92d
https://doi.org/10.1016/b978-0-12-416039-2.00004-5
https://doi.org/10.1016/b978-0-12-416039-2.00004-5
Thermochemical sulfate reduction experiments with simple amino acid and dilute concentrations of sulfate reveal significant degrees of mass-independent sulfur isotope fractionation. Enrichments of up to 13‰ for 33 S are attributed to a magnetic iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b7aa1deeccd06b668e15e88a5106a
https://europepmc.org/articles/PMC3203815/
https://europepmc.org/articles/PMC3203815/