Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

Autor: Brian H. Anderton, Laura Sturdee, Michael P. Coleman, Jean Pierre Brion, Diane P. Hanger, Jonathan Gilley, Teresa Rodriguez-Martin, Amy M. Pooler, Kunie Ando, Anjan Seereeram

Publikováno v: Neurobiology of aging, 39
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028

Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological process, we generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd259b2f04784efb0849659337928c3
https://doi.org/10.1016/j.neurobiolaging.2015.11.028

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

Autor: Pascal Derkinderen, Amy M. Pooler, Ritchie Williamson, Brian H. Anderton, Alessia Usardi, Diane P. Hanger, C. Hugh Reynolds, Wendy Noble, Anjan Seereeram

Publikováno v: FEBS Journal. 278:2927-2937

Recent reports have demonstrated that interactions between the microtubule-associated protein tau and the nonreceptor tyrosine kinase Fyn play a critical role in mediating synaptic toxicity and neuronal loss in response to β-amyloid (Aβ) in models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::181c2d25955872bb0d86ae3311397809
https://doi.org/10.1111/j.1742-4658.2011.08218.x

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Autor: Mariano A. Garcia-Blanco, Karen Anthony, Teresa Rodriguez-Martin, Jean-Marc Gallo, S. Gary Mansfield, Brian H. Anderton

Publikováno v: Human Molecular Genetics

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the MAPT gene, encoding the tau protein that accumulates in intraneuronal lesions in a number of neurodegenerative diseases. Several FTDP-17 mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc2a4b92fde0aae670b58500bdc4ac
http://europepmc.org/articles/PMC2722988

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

Autor: Anna M. Kinsey, John Stephenson, Claire J. Garwood, Wendy Noble, Brian H. Anderton, Diane P. Hanger

Publikováno v: The FASEB Journal. 23:739-750

Alzheimer's disease (AD) is characterized by the presence of neurofibrillary tangles of hyperphosphorylated, aggregated tau protein and extracellular deposits of beta-amyloid peptide. Increased beta-amyloid levels are thought to precede tangle format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d6a02d93e7fe6fcabc8b1106762930
https://doi.org/10.1096/fj.08-113795

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats

Autor: Brian H. Anderton, Malcolm Saxton, Selina Wray, Diane P. Hanger

Publikováno v: Journal of Neurochemistry. 105:2343-2352

Tangles containing hyperphosphorylated aggregates of insoluble tau are a pathological hallmark of progressive supranuclear palsy (PSP). Several phosphorylation sites on tau in PSP have been identified using phospho-specific antibodies, but no sites h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f386fa9557adc3153bc655e25d53c715
https://doi.org/10.1111/j.1471-4159.2008.05321.x