Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brian H K Chan"'
Autor:
Victoria C Barclay, Derek Sim, Brian H K Chan, Lucas A Nell, Maia A Rabaa, Andrew S Bell, Robin F Anders, Andrew F Read
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001368 (2012)
Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility that some types of vaccine could also create conditions favoring the evolution of more virulent pathogens.
Externí odkaz:
https://doaj.org/article/226e263b1947497aa18f70475a6dfc8a
Autor:
Andrew S Bell, Silvie Huijben, Krijn P Paaijmans, Derek G Sim, Brian H K Chan, William A Nelson, Andrew F Read
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37172 (2012)
The evolution of drug resistant Plasmodium parasites is a major challenge to effective malaria control. In theory, competitive interactions between sensitive parasites and resistant parasites within infections are a major determinant of the rate at w
Externí odkaz:
https://doaj.org/article/108fb64e4c4b4ccd980aadd54475c8b3
Autor:
Gonçalo Pimenta, Bahtiyar Yilmaz, Gina J. Fiala, Brian H. K. Chan, Bruno Silva-Santos, Pedro H. Papotto, Sofia Mensurado, Birte Blankenhaus, Daniel Gomes da Costa, Natacha Gonçalves-Sousa, Judith E. Allen, Carolina Cunha, Tânia Carvalho, Andrew J. Macpherson
Immune system development is greatly influenced by vertically transferred cues. However, beyond antibody-producing B cells, little is known about the role of other cell subsets of the maternal immune system in regulating offspring immunity. We reason
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245008ba50042058739ca60f781488b2
https://doi.org/10.1101/2021.08.13.456265
https://doi.org/10.1101/2021.08.13.456265
Autor:
Bahtiyar Yilmaz, Carolina Cunha, Pedro H. Papotto, Daniel Gomes da Costa, Judith E. Allen, Tânia Carvalho, Gonçalo Pimenta, Gina J. Fiala, Brian H. K. Chan, Natacha Gonçalves-Sousa, Andrew J. Macpherson, Sofia Mensurado, Birte Blankenhaus, Bruno Silva-Santos
Publikováno v:
SSRN Electronic Journal.
Immune development is greatly influenced by vertically transferred cues. However, beyond B cells, little is known about the role of other subsets of the maternal immune system in regulating offspring immunity. We found that mice born from γδT cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a0db1619493e41d4297d1405145bebe
https://doi.org/10.2139/ssrn.3903438
https://doi.org/10.2139/ssrn.3903438
Autor:
Jesuthas Ajendra, Richard K. Grencis, Alistair L Chenery, Brian H. K. Chan, James E Parkinson, Tara E. Sutherland, Judith E. Allen, Louis Boon, Stella Pearson, Stefano A. P. Colombo
Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production and neutrophilia. Using N. brasiliensis infection we confirm previous observations that Il17a-KO mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1e6bfe187f79c61413d47035497e55
Autor:
James E Parkinson, Stella Pearson, Judith E. Allen, Louis Boon, Tara E. Sutherland, Jesuthas Ajendra, Alistair L Chenery, Brian H. K. Chan, Stefano A. P. Colombo, Richard K. Grencis
Publikováno v:
Mucosal Immunology
Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production. In this study, we confirm previous observations that Il17a-KO mice infected with N. brasiliensis exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d982742e67c1b8d2c5dd64137a7513e8
https://pubmed.ncbi.nlm.nih.gov/32728131
https://pubmed.ncbi.nlm.nih.gov/32728131
Autor:
Paul R. Giacomin, Lindsay A. Dent, Avril A. B. Robertson, Ramon M. Eichenberger, Andreas Kupz, David Brough, Jesuthas Ajendra, Zainab Agha, Judith E. Allen, Alex Loukas, Martha M Cooper, Rafid Alhallaf, Alistair L Chenery, Brian H. K. Chan, Tara E. Sutherland, James E Parkinson
Publikováno v:
Chenery, A L, Alhallaf, R, Agha, Z, Ajendra, J, Parkinson, J E, Cooper, M M, Chan, B H K, Eichenberger, R M, Dent, L A, Robertson, A A B, Kupz, A, Brough, D, Loukas, A, Sutherland, T E, Allen, J E & Giacomin, P R 2019, ' Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung ', Journal of Immunology, vol. 203, no. 10, pp. 2724-2734 . https://doi.org/10.4049/jimmunol.1900640, https://doi.org/10.4049/jimmunol.1900640
The Journal of Immunology Author Choice
The Journal of Immunology Author Choice
Key Points Nlrp3−/− mice have enhanced early antihelminth immunity in the lung. Type 2 immunity and repair responses are dysregulated in Nlrp3−/− mice. NLRP3 plays an inflammasome-independent role during Nippostrongylus infection.
Altern
Altern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc46a5bd8a37cd9add6e339d9604f5ad
https://doi.org/10.4049/jimmunol.1900640
https://doi.org/10.4049/jimmunol.1900640
Autor:
Judith E. Allen, Andrew S. MacDonald, Tara E. Sutherland, James E Parkinson, Silvia Rosini, Alistair L Chenery, Brian H. K. Chan, Karl E. Kadler, Jeremy Herrera, Jesuthas Ajendra, Craig Lawless, P'ng Loke
Publikováno v:
Life Science Alliance
IL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.
IL-13 is implicated in effective repair after acute lung injury and the pathogenesis of chroni
IL-13 is implicated in effective repair after acute lung injury and the pathogenesis of chroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303aa73e8b121387a996090965471e53
https://doi.org/10.26508/lsa.202001000
https://doi.org/10.26508/lsa.202001000
Autor:
Shree Ram Singh, Ann Marie Weideman, Steven X. Hou, Jae Lee, Qinglan Ge, Jacob Manley, Ying Liu, Gerald Hou, Brian H. K. Chan, Hanhan Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
Stem cells are regulated both intrinsically and externally, including by signals from the local environment and distant organs. To identify genes and pathways that regulate stem-cell fates in the whole organism, we perform a genome-wide transgenic RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9b3fe3cd56278db7a55a6efcc675ed
https://doaj.org/article/4bacdc24e3e94f74b5fe7c8b9d8f0369
https://doaj.org/article/4bacdc24e3e94f74b5fe7c8b9d8f0369
Publikováno v:
Huijben, S, Chan, B H K, Nelson, W A & Read, A F 2018, ' The impact of within-host ecology on the fitness of a drug-resistant parasite ', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137 . https://doi.org/10.1093/emph/eoy016
Evolution, Medicine, and Public Health
Evolution, Medicine, and Public Health
We found that drug treatment could double the fitness of a resistant parasite or increase it 10 000-fold, depending on in-host ecology and choice of fitness measure. Conversely, in the absence of treatment, the absolute fitness of resistant parasites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c83e5905bf0989bfea655735505098
https://www.research.manchester.ac.uk/portal/en/publications/the-impact-of-withinhost-ecology-on-the-fitness-of-a-drugresistant-parasite(289c1b01-e708-435b-8784-2cdaf0072021).html
https://www.research.manchester.ac.uk/portal/en/publications/the-impact-of-withinhost-ecology-on-the-fitness-of-a-drugresistant-parasite(289c1b01-e708-435b-8784-2cdaf0072021).html