Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Brian H Annex"'
Autor:
Sarvenaz Sarabipour, Karina Kinghorn, Kaitlyn M Quigley, Anita Kovacs-Kasa, Brian H Annex, Victoria L Bautch, Feilim Mac Gabhann
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011798 (2024)
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and co-receptors such as Neuropilin (NRP) expressed on endothelial cells. T
Externí odkaz:
https://doaj.org/article/802e7e2a145742049f8b88dfb4c51551
Autor:
Chen Zhao, Adam C Mirando, Richard J Sové, Thalyta X Medeiros, Brian H Annex, Aleksander S Popel
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007468 (2019)
Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they acquire different patterns of transcriptional activation, cytokine expression and cellular
Externí odkaz:
https://doaj.org/article/5d56609b24fd4944b96a96ca96cfc190
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Peripheral arterial disease (PAD) results from atherosclerosis that leads to blocked arteries and reduced blood flow, most commonly in the arteries of the legs. PAD clinical trials to induce angiogenesis to improve blood flow conducted in the last de
Externí odkaz:
https://doaj.org/article/496c3c0771fd416e94180edd754aa6d7
Publikováno v:
Cells, Vol 11, Iss 17, p 2676 (2022)
Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials. O
Externí odkaz:
https://doaj.org/article/de1b4e0710294e768d98c29e0067d659
Autor:
Samson Okello, Fardous Charles Abeya, Boniface Amanee Elias Lumori, Suzan Joan Akello, Christopher Charles Moore, Brian H. Annex, Andrew J. Buda
Publikováno v:
BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background The health-related quality of life (HRQoL) is an important treatment goal that could serve as low-cost prognostication tool in resource poor settings. We sought to validate the Kansas City Cardiomyopathy Questionnaire (KCCQ) and e
Externí odkaz:
https://doaj.org/article/d5c2b6eef1d24121abe31a115460e9e2
Publikováno v:
bioRxiv
Several signaling pathways are activated during hypoxia to promote angiogenesis, leading to endothelial cell patterning, interaction, and downstream signaling. Understanding the mechanistic signaling differences between normoxia and hypoxia can guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a711a5cf0c1231d3da16d8262cb12e
https://doi.org/10.1101/2023.05.03.539270
https://doi.org/10.1101/2023.05.03.539270
Autor:
Abdelrahman A. Zaied, Masuko Ushio‐Fukai, Tohru Fukai, Anita Kovacs‐Kasa, Suhib Alhusban, Varadarajan Sudhahar, Vijay C. Ganta, Brian H. Annex
Publikováno v:
Journal of the American Heart Association. 12
Background In endothelial cells (ECs), glycolysis, regulated by PFKFB3 (6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase, isoform‐3), is the major metabolic pathway for ATP generation. In preclinical peripheral artery disease models, V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a20f8060fcf5169a289249c3714e4356
https://doi.org/10.1161/jaha.122.027986
https://doi.org/10.1161/jaha.122.027986
Autor:
Alyssa B. Becker, Lanlin Chen, Bo Ning, Song Hu, John A. Hossack, Alexander L. Klibanov, Brian H. Annex, Brent A. French
Publikováno v:
Ultrasound Med Biol
Mouse models are critical in developing new therapeutic approaches to treat peripheral arterial disease (PAD). Despite decades of research and numerous clinical trials, the efficacy of available therapies is limited. This may suggest shortcomings in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1f3b3217af4bd17ecb41b161a1df08
https://doi.org/10.1016/j.ultrasmedbio.2022.02.002
https://doi.org/10.1016/j.ultrasmedbio.2022.02.002
Autor:
Vijay Chaitanya Ganta, Young Min Haider, Melissa A. Marshall, Victoria Osinski, Coleen A. McNamara, Prasad Srikakulapu, Brian H. Annex
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:6-18
Objective:Neovascularization can maintain and even improve tissue perfusion in the setting of limb ischemia during peripheral artery disease. The molecular and cellular mechanisms mediating this process are incompletely understood. We investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6539b1db2bab4f4aa8e94d455f63ca84
https://doi.org/10.1161/atvbaha.120.315501
https://doi.org/10.1161/atvbaha.120.315501
Publikováno v:
JACC: Basic to Translational Science. 7:28-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a1f9c065c65cf1f1b578cade25b9d4
https://doi.org/10.1016/j.jacbts.2021.10.014
https://doi.org/10.1016/j.jacbts.2021.10.014