Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Brian H Annex"'
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Inflammatory cytokine mediated responses are important in the development of many diseases that are associated with angiogenesis. Targeting angiogenesis as a prominent strategy has shown limited effects in many contexts such as cardiovascula
Externí odkaz:
https://doaj.org/article/2a8d37f329e3460997a80c4e0c8de3c8
Autor:
Sarvenaz Sarabipour, Karina Kinghorn, Kaitlyn M Quigley, Anita Kovacs-Kasa, Brian H Annex, Victoria L Bautch, Feilim Mac Gabhann
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011798 (2024)
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and co-receptors such as Neuropilin (NRP) expressed on endothelial cells. T
Externí odkaz:
https://doaj.org/article/802e7e2a145742049f8b88dfb4c51551
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Introduction: Several signaling pathways are activated during hypoxia to promote angiogenesis, leading to endothelial cell patterning, interaction, and downstream signaling. Understanding the mechanistic signaling differences between endothelial cell
Externí odkaz:
https://doaj.org/article/d6a1fe86a84749dcb3ac94dfb726a0b5
Autor:
Maritza J. Romero, Qian Yue, Bhupesh Singla, Jürg Hamacher, Supriya Sridhar, Auriel S. Moseley, Chang Song, Mobarak A. Mraheil, Bernhard Fischer, Markus Zeitlinger, Trinad Chakraborty, David Fulton, Lin Gan, Brian H. Annex, Gabor Csanyi, Douglas C. Eaton, Rudolf Lucas
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAlthough both COVID-19 and non-COVID-19 ARDS can be accompanied by significantly increased levels of circulating cytokines, the former significantly differs from the latter by its higher vasculopathy, characterized by increased oxidative
Externí odkaz:
https://doaj.org/article/601f9caadea24ac78d5e6a33f31a23e1
Autor:
Abdelrahman A. Zaied, Masuko Ushio‐Fukai, Tohru Fukai, Anita Kovacs‐Kasa, Suhib Alhusban, Varadarajan Sudhahar, Vijay C. Ganta, Brian H. Annex
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
Background In endothelial cells (ECs), glycolysis, regulated by PFKFB3 (6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase, isoform‐3), is the major metabolic pathway for ATP generation. In preclinical peripheral artery disease models, V
Externí odkaz:
https://doaj.org/article/60f8ee88973f4765b94d72c3ae6ba420
Autor:
Monique Bethel, Brian H. Annex
Publikováno v:
American Heart Journal Plus, Vol 28, Iss , Pp 100291- (2023)
Peripheral arterial disease (PAD) is one clinical manifestation of systemic atherosclerosis and is very common. Despite its prevalence, PAD remains underdiagnosed, undertreated, and understudied. The most common symptom in patients with PAD is interm
Externí odkaz:
https://doaj.org/article/9472ae22e42048edb95578efbe7d19ae
Autor:
Hong Shi, Brandee Goo, David Kim, Taylor C. Kress, Mourad Ogbi, James Mintz, Hanping Wu, Eric J. Belin de Chantemèle, David Stepp, Xiaochun Long, Avirup Guha, Richard Lee, Laura Carbone, Brian H. Annex, David Y. Hui, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPatients with systemic lupus erythematosus (SLE) are at elevated risk for Q10 cardiovascular disease (CVD) due to accelerated atherosclerosis. Compared to heathy control subjects, lupus patients have higher volumes and densities of thorac
Externí odkaz:
https://doaj.org/article/b3e24e819659449f8f6a8f6219d60823
Autor:
Donglan Zhang, Yike Li, Corey Andrew Kalbaugh, Lu Shi, Jasmin Divers, Shahidul Islam, Brian H. Annex
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Background Peripheral artery disease (PAD) affects >10 million people in the United States. PAD is associated with poor outcomes, including premature death. Machine learning (ML) has been increasingly used on big data to predict clinical outcomes. Th
Externí odkaz:
https://doaj.org/article/36c7044e01f84f11878a7e4087a3a0b3
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract The Ang–Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular pe
Externí odkaz:
https://doaj.org/article/b76836dc5cf64ade854948acc776b695
Autor:
Anita Kovacs-Kasa, Abdelrahman A. Zaied, Silvia Leanhart, Murat Koseoglu, Supriya Sridhar, Rudolf Lucas, David J. Fulton, Jose A. Vazquez, Brian H. Annex
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT The vascular endothelial injury occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, but the mechanisms are poorly understood. We sought to determine the frequency and type of cytokine elevations and their relat
Externí odkaz:
https://doaj.org/article/5c044d2917e34f7cb29179a1d4784fb7