Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian Grone"'
Autor:
Aliesha Griffin, Colleen Carpenter, Jing Liu, Rosalia Paterno, Brian Grone, Kyla Hamling, Maia Moog, Matthew T. Dinday, Francisco Figueroa, Mana Anvar, Chinwendu Ononuju, Tony Qu, Scott C. Baraban
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assay
Externí odkaz:
https://doaj.org/article/bfcda728977044beb624cc6204edc73f
Autor:
Stella A. Belonwu, Yaqiao Li, Daniel G. Bunis, Arjun Arkal Rao, Caroline Warly Solsberg, Tomiko Oskotsky, Alice L. Taubes, Brian Grone, Kelly A. Zalocusky, Gabriela K. Fragiadakis, Yadong Huang, Marina Sirota
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecula
Externí odkaz:
https://doaj.org/article/8509af238faa46e3a867616383bbc66c
Autor:
Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Brian Grone, Misha Zilberter, Oscar Yip, Antara Rao, Maxine R. Nelson, Yanxia Hao, Reuben Thomas, Seo Yeon Yoon, Patrick Arriola, Yadong Huang
Publikováno v:
Nature aging, vol 3, iss 3
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afe5e2b3e90921ae536bd6d7cbbba0d
https://escholarship.org/uc/item/3mn2s8w7
https://escholarship.org/uc/item/3mn2s8w7
Autor:
Alice, Taubes, Phil, Nova, Kelly A, Zalocusky, Idit, Kosti, Mesude, Bicak, Misha Y, Zilberter, Yanxia, Hao, Seo Yeon, Yoon, Tomiko, Oskotsky, Silvia, Pineda, Bin, Chen, Emily A Aery, Jones, Krishna, Choudhary, Brian, Grone, Maureen E, Balestra, Fayzan, Chaudhry, Ishan, Paranjpe, Jessica, De Freitas, Nicole, Koutsodendris, Nuo, Chen, Celine, Wang, William, Chang, Alice, An, Benjamin S, Glicksberg, Marina, Sirota, Yadong, Huang
Publikováno v:
Nat Aging
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280579c1090f3d62b13565055133fa5b
https://pubmed.ncbi.nlm.nih.gov/36172600
https://pubmed.ncbi.nlm.nih.gov/36172600
Autor:
Stella A, Belonwu, Yaqiao, Li, Daniel G, Bunis, Arjun Arkal, Rao, Caroline Warly, Solsberg, Tomiko, Oskotsky, Alice L, Taubes, Brian, Grone, Kelly A, Zalocusky, Gabriela K, Fragiadakis, Yadong, Huang, Marina, Sirota
Publikováno v:
Frontiers in aging neuroscience. 14
Alzheimer's Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fa4b1a2b040ed7dd32f8fa747698a77
https://pubmed.ncbi.nlm.nih.gov/35572130
https://pubmed.ncbi.nlm.nih.gov/35572130