Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Brian Geist"'
1
Akademický článek
A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model
Autor: Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
Publikováno v: Clinical and Translational Science, Vol 16, Iss 8, Pp 1431-1444 (2023)
Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐l
Externí odkaz: https://doaj.org/article/c585a6f12b244dfba472ff6c70f4a613
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2
Akademický článek
Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment
Autor: Ian White, Ninkka Tamot, Rajitha Doddareddy, Jason Ho, Qun Jiao, Paul B. Harvilla, Tong-Yuan Yang, Brian Geist, M. Jack Borrok, Matthew D. Truppo, Rajkumar Ganesan, Partha Chowdhury, Adam Zwolak
Publikováno v: mAbs, Vol 13, Iss 1 (2021)
The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effecti
Externí odkaz: https://doaj.org/article/a6460b31f1584b1b94ecaa2b69a6345e
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3
Akademický článek
A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model
Autor: Songmao Zheng, Jin Niu, Brian Geist, Damien Fink, Zhenhua Xu, Honghui Zhou, Weirong Wang
Publikováno v: mAbs, Vol 12, Iss 1 (2020)
Biotherapeutic drugs against tumor necrosis factor (TNF) are effective treatments for moderate to severe inflammatory bowel disease (IBD). Here, we evaluated CNTO 5048, an antimurine TNF surrogate monoclonal antibody (mAb), in a CD45RBhigh adoptive T
Externí odkaz: https://doaj.org/article/88dc0ad39bff48c0ae6be80ae381adac
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4
Akademický článek
Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics
Autor: Bharathikumar Vellalore Maruthachalam, Adam Zwolak, Xiefan Lin-Schmidt, Edward Keough, Ninkka Tamot, Sathya Venkataramani, Brian Geist, Sanjaya Singh, Rajkumar Ganesan
Publikováno v: mAbs, Vol 12, Iss 1 (2020)
Mucosal immunity is dominated by secretory IgA and IgM, although these are less favorable compared to IgG molecules for therapeutic development. Polymeric IgA and IgM are actively transported across the epithelial barrier via engagement of the polyme
Externí odkaz: https://doaj.org/article/cc4b8f1cd804465a927601f8505a713a
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5
Akademický článek
Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A
Autor: Songmao Zheng, Fang Shen, Brian Jones, Damien Fink, Brian Geist, Ivo Nnane, Zhao Zhou, Jeff Hall, Ravi Malaviya, Tatiana Ort, Weirong Wang
Publikováno v: mAbs, Vol 12, Iss 1 (2020)
Tumor necrosis factor (TNF) and interleukin (IL)-17A are pleiotropic cytokines implicated in the pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). JNJ-61178104 is a novel human anti-TNF and
Externí odkaz: https://doaj.org/article/14de5e65d91743cea20438bf02341a93
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6
A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese non-human primate model
Autor: Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin-Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
GDF15 is a circulating polypeptide associated with cellular stress, and recently linked to metabolic adaptation. GDF15 has a half-life of approximately 3 hours in and acts at the GFRAL receptor selectively expressed in the area postrema. To character
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88e026a2285071a87eb1de41ecc7ec4a
https://doi.org/10.1101/2022.12.05.519153
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7
Application of multiplexed pharmacokinetic immunoassay to quantify in vivo drug forms and coadministered biologics
Autor: Nicole Woodbury, Brian Geist, Tong-Yuan Yang, Eric Bald
Publikováno v: Bioanalysis. 11:2251-2268
Aim: Meso Scale Discovery U-PLEX® provides an opportunity to develop multiplexed pharmacokinetic (PK) immunoassays. Two case studies demonstrate the utility of multiplexed PK methods. Materials & methods: Development of PK ligand-binding assays quan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1255d88c6da081b33230fd56fc0a8c2
https://doi.org/10.4155/bio-2019-0147
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10
Translational PK/PD and model-informed development of JNJ-67842125, a F
Autor: Vivaswath S, Ayyar, Pharavee, Jaiprasart, Brian, Geist, Zheng, Huang Devine, Martin, Case, Anasuya, Hazra, Chyi-Hung, Hsu, Madhu, Chintala, Weirong, Wang
Publikováno v: British journal of pharmacologyREFERENCES. 178(19)
Antigen-binding fragment (FThe pharmacokinetic and pharmacodynamic (PK/PD) activities of three reversal agents of varying in vitro binding affinities to JNJ-9375 were characterised in cynomolgus monkeys. The time course of JNJ-9375 anticoagulant acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c263d25e40a5dcde82c91b6cb91a4f5
https://pubmed.ncbi.nlm.nih.gov/34008170
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