Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian Gadie"'
Publikováno v:
Journal of psychopharmacology (Oxford, England). 4(2)
The behavioural effects of the specific and selective α2-adrenoreceptor antagonists, idazoxan, efaroxan and RX811059, have been investigated in the rat. All three drugs induced periods of behavioural activation characterized by increased locomotion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5189ae04b4bca627e1818398631b5007
https://pubmed.ncbi.nlm.nih.gov/22282933
https://pubmed.ncbi.nlm.nih.gov/22282933
Publikováno v:
Journal of Psychopharmacology. 5:187-195
The α2-adrenoceptor antagonists idazoxan and RX811059 induced reciprocal forepaw treading, a component of the 5-HT-behavioural syndrome in rats. This response is independent of 'non-α2-adrenoceptor idazoxan binding sites' (NAIBS) at which RX811059
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919f41bb3810bcb43d0410136dc44aea
https://doi.org/10.1177/026988119100500302
https://doi.org/10.1177/026988119100500302
Publikováno v:
Psychopharmacology. 96:521-527
The importance of dopamine (DA) in mediating locomotor, exploratory and stereotyped behaviour in rodents is well established. Evidence also indicates a modulatory role for noradrenaline (NA) although, due to nonspecificity. of previously available ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47463ac5862b852dda516ff657ad0e5b
https://doi.org/10.1007/bf02180034
https://doi.org/10.1007/bf02180034
Antihypertensive thiadiazoles. 2. Vasodilator activity of some 2-aryl-5-guanidino-1,3,4-thiadiazoles
Autor:
Brian Gadie, Anthony J. Nelson, Stephen Turner, Robin Pape, Malcolm Myers, Stafford A. Hale, John F. Saville, John C. Doxey, Timothy L. Berridge, Alan Horsley
Publikováno v:
Journal of Medicinal Chemistry. 31:906-913
Some 2-aryl-5-guanidino-(or N-substituted guanidino)-1,3,4-thiadiazoles and closely related analogues were found to lower blood pressure in metacorticoid (DOCA) hypertensive rats. In the unsubstituted guanidines that exhibited low toxicity, optimum a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf35319dc4bb28f9f908cf5774434c1
https://doi.org/10.1021/jm00400a004
https://doi.org/10.1021/jm00400a004
Autor:
Brian Gadie, Malcolm Myers, Robin Pape, Stephen Turner, John F. Saville, Timothy L. Berridge, Anthony J. Nelson, John C. Doxey
Publikováno v:
Journal of medicinal chemistry. 31(5)
Some 2-aryl-5-hydrazino-1,3,4-thiadiazoles have been synthesized and screened for antihypertensive activity. In general, compounds with a 2-substituted phenyl ring had higher activity than their 3- or 4-substituted counterparts or those containing he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b6f0cb2712d7650266926a69261673
https://pubmed.ncbi.nlm.nih.gov/3361578
https://pubmed.ncbi.nlm.nih.gov/3361578