Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Brian G. Sutherland"'
1
Akademický článek
The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]
Autor: Nadya M. Morrow, Amy C. Burke, Joshua P. Samsoondar, Kyle E. Seigel, Andrew Wang, Dawn E. Telford, Brian G. Sutherland, Conor O'Dwyer, Gregory R. Steinberg, Morgan D. Fullerton, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 61, Iss 3, Pp 387-402 (2020)
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions. The flavonoid nobiletin displays potent lipid-lowering and insulin-s
Externí odkaz: https://doaj.org/article/4cda3eb4c2104e2fabdf5d55dfd633bf
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2
Akademický článek
Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice
Autor: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Maria Drangova, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity
Externí odkaz: https://doaj.org/article/761ce2d5872b400187ff5a277fcec253
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3
Akademický článek
PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Autor: Lazar A. Bojic, Dawn E. Telford, Morgan D. Fullerton, Rebecca J. Ford, Brian G. Sutherland, Jane Y. Edwards, Cynthia G. Sawyez, Robert Gros, Bruce E. Kemp, Gregory R. Steinberg, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 55, Iss 7, Pp 1254-1266 (2014)
PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol
Externí odkaz: https://doaj.org/article/02e95e718419411d991a2cb2fb2378cb
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4
Akademický článek
Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr−/− mice[S]
Autor: Julia M. Assini, Erin E. Mulvihill, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Sarah L. Felder, Sanjiv Chhoker, Jane Y. Edwards, Robert Gros, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 54, Iss 3, Pp 711-724 (2013)
Obesity-associated chronic inflammation contributes to metabolic dysfunction and propagates atherosclerosis. Recent evidence suggests that increased dietary cholesterol exacerbates inflammation in adipose tissue and liver, contributing to the proathe
Externí odkaz: https://doaj.org/article/158247674e644e5aa756021704b6e7ce
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5
Akademický článek
The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatins⃞
Autor: Dawn E. Telford, Brian G. Sutherland, Jane Y. Edwards, Joseph D. Andrews, P. Hugh R. Barrett, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 48, Iss 3, Pp 699-708 (2007)
The combination of ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein (NPC1L1), and an HMG-CoA reductase inhibitor decreases cholesterol absorption and synthesis. In clinical trials, ezetimibe plus simvastatin produces greater LDL-cholesterol
Externí odkaz: https://doaj.org/article/73153f7bd3b74244833b1ec270c77e66
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6
Nobiletin Prevents High-Fat Diet-Induced Dysregulation of Intestinal Lipid Metabolism and Attenuates Postprandial Lipemia
Autor: Nadya M. Morrow, Natasha A. Trzaskalski, Antonio A. Hanson, Evgenia Fadzeyeva, Dawn E. Telford, Sanjiv S. Chhoker, Brian G. Sutherland, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42:127-144
Objective: Nobiletin is a dietary flavonoid that improves insulin resistance and atherosclerosis in mice with metabolic dysfunction. Dysregulation of intestinal lipoprotein metabolism contributes to atherogenesis. The objective of the study was to de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8d86c65e0ba1455c85db28e5307b0b
https://doi.org/10.1161/atvbaha.121.316896
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7
The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]
Autor: Murray W. Huff, Nadya M. Morrow, Conor O’Dwyer, Andrew Wang, Gregory R. Steinberg, Morgan D. Fullerton, Joshua P. Samsoondar, Kyle E. Seigel, Amy C. Burke, Dawn E. Telford, Brian G. Sutherland
Publikováno v: Journal of Lipid Research, Vol 61, Iss 3, Pp 387-402 (2020)
J Lipid Res
Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions. The flavonoid nobiletin displays potent lipid-lowering and insulin-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6500219509b0a717dcf54cb2ee8651
http://www.sciencedirect.com/science/article/pii/S0022227520435229
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8
Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia
Autor: Zengxuan Nong, Rachel B. Wilson, J. Geoffrey Pickering, Hao Yin, Chanho Park, Kia M. Peters, Richard Zhang, Cynthia G. Sawyez, Brian G. Sutherland, Nica M. Borradaile
Publikováno v: The Journal of Nutritional Biochemistry. 70:65-74
Vitamin D appears to either promote or inhibit neovascularization in a disease context-dependent manner. The effects of vitamin D, alone or in combination with niacin, on endothelial cell (EC) angiogenic function and on revascularization in obese ani
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca08e42741e2e7b3a22b302bf7081597
https://doi.org/10.1016/j.jnutbio.2019.04.010
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9
Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice
Autor: Marisa R. Morrow, Brian G. Sutherland, Jane Y. Edwards, Dawn E. Telford, Amy C. Burke, Maria Drangova, Cynthia G. Sawyez, Murray W. Huff
Publikováno v: Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Medical Biophysics Publications
Bone and Joint Institute
Copyright © 2018 Burke et al. Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f221864abbec4ab66bd0eb13e40524dd
http://www.sciencedirect.com/science/article/pii/S0022227520335409
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10
Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient ( LDLR +/− and LDLR −/− ) Yucatan Miniature Pigs
Autor: Jane Y. Edwards, J. Geoffrey Pickering, Brian G. Sutherland, Cynthia G. Sawyez, Amy C. Burke, Murray W. Huff, Dawn E. Telford, P. Hugh R. Barrett, Roger S. Newton
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1178-1190
Objective— Bempedoic acid (BemA; ETC-1002) is a novel drug that targets hepatic ATP-citrate lyase to reduce cholesterol biosynthesis. In phase 2 studies, BemA lowers elevated low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemic patie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d464461bfa4ff8f963650f27381fecd7
https://doi.org/10.1161/atvbaha.117.310676
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