Výsledky vyhledávání - "Brian G. Pring"

Penetration Enhancers and Other Factors Governing Percutaneous Local Anaesthesia with Lidocaine

Autor: Glenn Haegerstam, Rune Sandberg, B. Åkerman, Brian G. Pring

Publikováno v: Acta Pharmacologica et Toxicologica. 45:58-65

The percutaneous penetration of the local anaestetic lidocaine was investigated in the guinea-pig. Three different types of composition were employed: lidocaine hydrochloride in aqueous solution, lidocaine base in an aqueous alcoholic solvent mixture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba13cc19f65cf22aa213f18b362fdb4a
https://doi.org/10.1111/j.1600-0773.1979.tb02361.x

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Neoglycolipid Conjugates of Foscarnet with Enhanced Antiviral Activity in Cells Infected with Human Cytomegalovirus and Herpes Simplex Virus Type 1

Autor: Jeannette Dypbukt, Ewa Ljungdahl-Ståhle, Jean-Luc Maloisel, Anna-Karin Ulla Edit Tiden, Brian G. Pring

Publikováno v: Antiviral Chemistry and Chemotherapy. 10:333-345

The synthesis of a series of neoglycolipid conjugates of foscarnet as potential drug targeting forms or lipophilic prodrugs of foscarnet is described. The compounds were obtained from suitably protected neoglycolipids, in which the lipid chain consis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106614087a724d6a178d844720bd6d7e
https://doi.org/10.1177/095632029901000605

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S-Acylthioethyl prodrugs of phosphonoformate

Autor: Jan Lundström, Andrew D. Briggs, Sally Freeman, Michel Camplo, Brian G. Pring

Publikováno v: European Journal of Pharmaceutical Sciences. 5:199-208

Due to its highly ionic nature, the antiviral phosphonoformate shows poor penetration into cells and here bioreversible prodrugs of phosphonoformate are designed in an attempt to improve its transport properties. The key step in the syntheses of tri[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16cca19a76f52b6166ae0782d41a5d1a
https://doi.org/10.1016/s0928-0987(97)00281-9

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Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate

Autor: Sally Freeman, Andrew D. Briggs, Michel Camplo, Brian G. Pring, Jan Lundström

Publikováno v: Tetrahedron. 52:14937-14950

Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4 , sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a28ea1652f978f163af29fb591013d2
https://doi.org/10.1016/0040-4020(96)00906-4

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Synthesis of analogues of 3-deoxy-d-manno-octulosonic acid (KDO) as potential inhibitors of CMP-KDO synthetase

Autor: Anita M. Jansson, Brian G. Pring, Alf Claesson, Kristina Luthman

Publikováno v: Carbohydrate Research. 166:233-251

A series of derivatives of the 2-deoxy analogue of beta-KDO (2,6-anhydro-3-deoxy-D-glycero-D-talo-octonic acid; ammonium salt, 2) has been synthesised as potential inhibitors of CMP-KDO synthetase, starting from methyl 2,6-anhydro-3-deoxy-4,5:7,8-di-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ad592e2b89e106a4a0d3fb30f6018f
https://doi.org/10.1016/0008-6215(87)80060-5

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