Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brian G. O'Flynn"'
Autor:
Daniel R. Dempsey, Derek A. Nichols, Matthew R. Battistini, Orville Pemberton, Santiago Rodriguez Ospina, Xiujun Zhang, Anne-Marie Carpenter, Brian G. O’Flynn, James W. Leahy, Ankush Kanwar, Eric M. Lewandowski, Yu Chen, David J. Merkler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an or
Externí odkaz:
https://doaj.org/article/b2083b0e3aaf4cd49387f1ef030550cb
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Arylalkylamine N-acyltransferases (AANATs) catalyze the formation of an N-acylamide from an acyl-CoA thioester and an amine. One well known example is the production of N-acetylserotonin from acetyl-CoA and serotonin, a reaction in the melatonin bios
Externí odkaz:
https://doaj.org/article/d8271039a7cb4863962be61053b67e55
Publikováno v:
Molecular Cell. 83:731-745.e4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cc231e1fdef597d0d75750fbf0b0146
https://doi.org/10.1016/j.molcel.2022.12.033
https://doi.org/10.1016/j.molcel.2022.12.033
Autor:
Gabriela Suarez, Eric M. Lewandowski, Yu Chen, David J. Merkler, Nasha M Rios-Guzman, Karin Claire Prins, Ioannis Gelis, Britney A. Shepherd, James W. Leahy, Ryan L. Anderson, Angelica N McCaskey, Brian G. O'Flynn
Publikováno v:
ACS Chemical Biology. 15:513-523
The growing issue of insecticide resistance has meant the identification of novel insecticide targets has never been more important. Arylalkylamine N-acyltransferases (AANATs) have been suggested as a potential new target. These promiscuous enzymes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3791a5745132aba9dd63b58601dc2eec
https://doi.org/10.1021/acschembio.9b00973
https://doi.org/10.1021/acschembio.9b00973
Autor:
Brian G. O'Flynn, Tanja Mittag
Publikováno v:
Nature Chemical Biology. 17:628-630
Liquid–liquid phase separation can increase the rate of enzyme activity by concentrating reactants together. A phase-separating SUMOylation cascade offers conceptual and quantitative insight into the mechanisms underlying the activity enhancement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9706148153a5f3531459392c0e5d11df
https://doi.org/10.1038/s41589-021-00799-2
https://doi.org/10.1038/s41589-021-00799-2
Autor:
Brian G. O'Flynn, Lamar Galloway, Christopher Shoji, David J. Merkler, Matthew R. Battistini, Gabriela Suarez
Publikováno v:
Archives of Biochemistry and Biophysics. 661:107-116
The arylalkylamine N-acyltransferases (AANATs) are enzymes that catalyze the acyl-CoA-dependent formation of N-acylarylalkylamides: acyl-CoA + arylalkylamine → N-acylarylalkylamides + CoA-SH. Herein, we describe our study of a previously uncharacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e2010cc6d60996e2f78b153d5c9bfa
https://doi.org/10.1016/j.abb.2018.11.015
https://doi.org/10.1016/j.abb.2018.11.015
Autor:
Tanja Mittag, Brian G. O'Flynn
Publikováno v:
Curr Opin Cell Biol
Liquid-liquid phase separation is now recognized as a common mechanism for regulating enzyme activity in cells. Insights from studies in cells are complemented by in vitro studies aimed at developing better understanding of mechanisms underlying such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966a3cc32a6d9ae167c6dd589c1736a7
https://europepmc.org/articles/PMC8058252/
https://europepmc.org/articles/PMC8058252/
Autor:
Brian G. O'Flynn, David J. Merkler, Gabriela Suarez, Karin Claire Prins, Britney A. Shepherd, Victoria E. Forbrich
Publikováno v:
Protein Expr Purif
The assumption that structural or sequential homology between enzymes implies functional homology is a common misconception. Through in-depth structural and kinetic analysis, we are now beginning to understand the minute differences in primary struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df0d06882339bece19d16decf9e0165
https://pubmed.ncbi.nlm.nih.gov/32681959
https://pubmed.ncbi.nlm.nih.gov/32681959
Autor:
Brian G, O'Flynn, Eric M, Lewandowski, Karin Claire, Prins, Gabriela, Suarez, Angelica N, McCaskey, Nasha M, Rios-Guzman, Ryan L, Anderson, Britney A, Shepherd, Ioannis, Gelis, James W, Leahy, Yu, Chen, David J, Merkler
Publikováno v:
ACS chemical biology. 15(2)
The growing issue of insecticide resistance has meant the identification of novel insecticide targets has never been more important. Arylalkylamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96bae39571a2671810df6ff11c61d52b
https://pubmed.ncbi.nlm.nih.gov/31967772
https://pubmed.ncbi.nlm.nih.gov/31967772
Autor:
David J. Merkler, Dylan J. Wallis, John E. Dillashaw, Ryan L. Anderson, Matthew R. Battistini, Christopher Shoji, Brian G. O'Flynn
The purpose of this research is to unravel the substrate specificity and kinetic properties of an insect arylalkylamine N-acyltransferase from Bombyx mori (Bm-iAANAT) and to determine if this enzyme will catalyze the formation of long chain N-acylary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cadd25ff3883c7ea23583883eaabae
https://europepmc.org/articles/PMC6093294/
https://europepmc.org/articles/PMC6093294/