Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Brian G. Barnett"'
Autor:
Brian G. Barnett, Sonya R. Wesselowski, Sonya G. Gordon, Ashley B. Saunders, Daniel E. L. Promislow, Stephen M. Schwartz, Lucy Chou, Jeremy B. Evans, Matt Kaeberlein, Kate E. Creevy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Introduction:Geroscience studies of low-dose rapamycin in laboratory species have identified numerous benefits, including reversing age-related cardiac dysfunction. Cardiovascular benefits have been observed in dogs with 10 weeks of treatment, raisin
Externí odkaz:
https://doaj.org/article/ef31f02892114e298f3e2dcb672c9fd0
Autor:
Dora Praczko, Amanda K. Tinkle, Crystal R. Arkenberg, Robyn L. McClelland, Kate E. Creevy, M. Katherine Tolbert, Brian G. Barnett, Lucy Chou, Jeremy Evans, Kellyn E. McNulty, Dog Aging Project Consortium, Jonathan M. Levine
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Here we describe the development and evaluation of a survey instrument to assess the research suitability of veterinary electronic medical records (EMRs) through the conduct of two studies as part of the Dog Aging Project (DAP). In study 1, four revi
Externí odkaz:
https://doaj.org/article/a3cc331eb463429aab595ac2eb678b9f
Autor:
Kellyn E. McNulty, Kate E. Creevy, Annette Fitzpatrick, Vanessa Wilkins, Brian G. Barnett, Audrey Ruple
Publikováno v:
Journal of the American Veterinary Medical Association. :1-11
OBJECTIVE The researchers and clinicians within the Dog Aging Project (DAP), a longitudinal cohort study of aging in companion dogs, created and validated a novel survey instrument titled the End of Life Survey (EOLS) to gather owner-reported mortali
Autor:
Brian G. Barnett, Dana Hurley, James A. Kaye, Isobel Pearson, Catherine Copley-Merriman, Beverly Moy, Tina Krieger, Catherine Masaquel
Publikováno v:
Cancer Research. 78:P3-10
Background: Despite available treatment for early-stage breast cancer (BC), 15%-25% of patients with early-stage human epidermal growth factor receptor 2–positive (HER2+) BC eventually experience recurrence after initial treatment. The prognosis fo
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 26:153-157
Human leukocyte antigen G (HLA-G) is an immunotolerant nonclassical major histocompatibility complex Class Ib molecule. It is expressed by trophoblastic placental cells during pregnancy to protect the fetus from maternal alloreactivity. HLA-G is over
Autor:
Brian G. Barnett, Weiping Zou, Tyler J. Curiel, Ilona Kryczek, George Coukos, Benjamin J. Daniel, Michael J. Brumlik, Jens Rüter
Publikováno v:
Expert Review of Dermatology. 1:589-597
Malignant tumors express associated antigens that should make them objects of immune attack. Nonetheless, spontaneous immune clearance of established cancer is rare. Recent evidence demonstrates that cancers use active mechanisms to block host antitu
Autor:
Peter Mottram, Odile David, Linhua Zou, Vincent F. LaRussa, Weiping Zou, Melina Evdemon-Hogan, Tyler J. Curiel, Brian G. Barnett, Hana Safah, Shuang Wei
Publikováno v:
Cancer Research. 64:8451-8455
CD4+CD25+ regulatory T cells (Tregs) mediate peripheral T-cell homeostasis and contribute to self-tolerance. Their homeostatic and pathologic trafficking is poorly understood. Under homeostatic conditions, we show a relatively high prevalence of func
Autor:
Ilona Kryczek, Weiping Zou, Brian G. Barnett, Tyler J. Curiel, George Coukos, Jens Rüter, Michael J. Brumlik, Benjamin J. Daniel
Publikováno v:
Frontiers in bioscience (Landmark edition). 14(5)
Cancers express tumor associated antigens that should elicit immune attack, but spontaneous immune rejection of established cancer is rare. Recent data demonstrate that specific and active tumor-mediated mechanisms hinder host anti-tumor immunity. CD
Publikováno v:
Expert opinion on biological therapy. 8(12)
Both genetic and environmental factors contribute to the formation of alloantibodies that bind to functional domains on the Factor VIII (FVIII) molecule and inhibit its function. Patients with hemophilia A who develop high-titer inhibitors are at inc
Publikováno v:
Current opinion in hematology. 15(5)
Acquired hemophilia is a rare autoimmune disease that can result in life-threatening bleeding if not treated effectively. Appropriate management requires the urgent treatment of bleeding episodes and prompt institution of immunosuppressive therapy fo