Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Brian G Pierce"'
Autor:
Rui Yin, Johnathan D Guest, Ghazaleh Taherzadeh, Ragul Gowthaman, Ipsa Mittra, Jane Quackenbush, Brian G Pierce
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009380 (2021)
The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of protective antibody responses. This is underscored by the emergence and spread of SARS-CoV-2 variants, including Alpha (B.1.1.7) and Delta (B.1.617.2), some of whic
Externí odkaz:
https://doaj.org/article/e124a4e516d34a9fbdf3e223838d242e
Autor:
Zhen-Yong Keck, Brian G Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R Walker, Fabio Luciani, Johnathan D Guest, Catherine Fauvelle, Thomas F Baumert, Jens Bukh, Andrew R Lloyd, Steven K H Foung
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007772 (2019)
Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and specificity of the B cell response associated with clearance is
Externí odkaz:
https://doaj.org/article/02ca33a0a5d144a7a284f9c9f72f99b4
Autor:
Brian G Pierce, Lance M Hellman, Moushumi Hossain, Nishant K Singh, Craig W Vander Kooi, Zhiping Weng, Brian M Baker
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 2, p e1003478 (2014)
T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, ther
Externí odkaz:
https://doaj.org/article/9a4c08b9b45e4c7ea4f396e85ae6b134
Autor:
Gregory J Babcock, Sowmya Iyer, Heidi L Smith, Yang Wang, Kirk Rowley, Donna M Ambrosino, Phillip D Zamore, Brian G Pierce, Deborah C Molrine, Zhiping Weng
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100325 (2014)
Chronic hepatitis C virus (HCV) infection is the most common cause of end-stage liver disease, often leading to liver transplantation, in which case circulating virions typically infect the transplanted liver within hours and viral concentrations can
Externí odkaz:
https://doaj.org/article/443c65ec108248369f81119f193b6e34
Autor:
Debajit Dey, Enya Qing, Yanan He, Yihong Chen, Benjamin Jennings, Whitaker Cohn, Suruchi Singh, Lokesh Gakhar, Nicholas J. Schnicker, Brian G. Pierce, Julian P. Whitelegge, Balraj Doray, John Orban, Tom Gallagher, S. Saif Hasan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The spike (S) protein of SARS-CoV-2 is delivered to the virion assembly site in the ER-Golgi Intermediate Compartment (ERGIC) from both the ER and cis-Golgi in infected cells. However, the relevance and modulatory mechanism of this bidirecti
Externí odkaz:
https://doaj.org/article/f85c779209414774853f75b4271ccf93
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24657 (2011)
Computational prediction of the 3D structures of molecular interactions is a challenging area, often requiring significant computational resources to produce structural predictions with atomic-level accuracy. This can be particularly burdensome when
Externí odkaz:
https://doaj.org/article/d9239139f3104ada9fbb96eabc8a9e1d
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
Matthew C. Metcalf, Benjamin M. Janus, Rui Yin, Ruixue Wang, Johnathan D. Guest, Edwin Pozharski, Mansun Law, Roy A. Mariuzza, Eric A. Toth, Brian G. Pierce, Thomas R. Fuerst, Gilad Ofek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 sur
Externí odkaz:
https://doaj.org/article/5c8f3813e8b4474bb3fa9ada06482823
Autor:
Brian G. Pierce, Nathaniel Felbinger, Matthew Metcalf, Eric A. Toth, Gilad Ofek, Thomas R. Fuerst
Publikováno v:
Viruses, Vol 16, Iss 5, p 803 (2024)
Hepatitis C virus (HCV) is a major medical health burden and the leading cause of chronic liver disease and cancer worldwide. More than 58 million people are chronically infected with HCV, with 1.5 million new infections occurring each year. An effec
Externí odkaz:
https://doaj.org/article/af9cc06e950b41f584ef5b3cb302dc5d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable cancer regression. Tumor-specific T cells are also the basis of other therapies, notably cancer vaccines. The main target of tumor-specific T cells are neoantig
Externí odkaz:
https://doaj.org/article/77ed598acda54e73a773868631ad76f2