Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

Autor: Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed, Stephen L Atkin

Publikováno v: BMC Endocrine Disorders, Vol 17, Iss 1, Pp 1-5 (2017)

Abstract Background Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) m

Externí odkaz: https://doaj.org/article/b74168a54e7b4524b606dee344819403

Association of sex hormones with physical, laboratory, and imaging markers of anthropometry in men and women from the general population.

Autor: Tom Seyfart, Nele Friedrich, Hanna Kische, Robin Bülow, Henri Wallaschofski, Henry Völzke, Matthias Nauck, Brian G Keevil, Robin Haring

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0189042 (2018)

The aim of this study was to evaluate the association of sex hormones with anthropometry in a large population-based cohort, with liquid chromatography-mass spectrometry (LCMS)-based sex hormone measurements and imaging markers.Cross-sectional data f

Externí odkaz: https://doaj.org/article/e7e3f869b8234adda60e35577af028bb

Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population.

Autor: Robin Haring, Claudia Schurmann, Georg Homuth, Leif Steil, Uwe Völker, Henry Völzke, Brian G Keevil, Matthias Nauck, Henri Wallaschofski

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127466 (2015)

Despite observational evidence from epidemiological and clinical studies associating sex hormones with various cardiometabolic risk factors or diseases, pathophysiological explanations are sparse to date. To reveal putative functional insights, we an

Externí odkaz: https://doaj.org/article/250e254db5c54bf1a1d6a007c072fd18

Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation

Autor: Lina Schiffer, Punith Kempegowda, Alice J Sitch, Joanne E Adaway, Fozia Shaheen, Andreas Ebbehoj, Sumitabh Singh, Malcom P McTaggart, Michael W O’Reilly, Alessandro Prete, James M Hawley, Brian G Keevil, Irina Bancos, Angela E Taylor, Wiebke Arlt

Publikováno v: Schiffer, L, Kempegowda, P, Sitch, A J, Adaway, J E, Shaheen, F, Ebbehoj, A, Singh, S, McTaggart, M, O'Reilly, M W, Prete, A, Hawley, J M, Keevil, B G, Bancos, I, Taylor, A E & Arlt, W 2023, ' Classic and 11-oxygenated androgens in serum and saliva across adulthood : a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation ', European Journal of Endocrinology, vol. 188, no. 1 . https://doi.org/10.1093/ejendo/lvac017

Objective 11-oxygenated androgens significantly contribute to the circulating androgen pool. Understanding the physiological variation of 11-oxygenated androgens and their determinants is essential for clinical interpretation, for example, in androge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c496ba506c415469c8c147d663930156
https://doi.org/10.1093/ejendo/lvac017

A rapid LC-MS/MS assay for the measurement of serum methotrexate in patients who have received high doses for chemotherapy

Autor: Brian G. Keevil, Malcolm Peter McTaggart

Publikováno v: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 58:599-604

Background Methotrexate is used in high doses to treat a number of cancers, particularly certain haematological malignancies. Monitoring of serum methotrexate concentration is important due to the potential toxicity of methotrexate and the variation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3dcebf478a6666d0ffa9155d65a8fd
https://doi.org/10.1177/00045632211031284