Výsledky vyhledávání - "Brian F. Tack"

Developmental expression and distribution of sheep β-defensin-2

Autor: Mark R. Ackermann, David K. Meyerholz, Richard B. Evans, Brian F. Tack, Branka Grubor, Jack M. Gallup, Paul B. McCray

Publikováno v: Developmental & Comparative Immunology. 28:171-178

The aim of this study was to define the ontogeny of sheep beta-defensin-2 (SBD-2) mRNA and peptide in selected tissues of fetal, neonatal and adult sheep by real-time PCR and immunohistochemistry, respectively. Fetal and neonatal lambs had significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2efcb8c182ede3e3217920bb25714e
https://doi.org/10.1016/s0145-305x(03)00105-8

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Antimicrobial peptides in animals and their role in host defences

Autor: Paul B. McCray, Mark R. Ackermann, Brian F. Tack, Kim A. Brogden

Publikováno v: International Journal of Antimicrobial Agents. 22:465-478

Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a2eba292b47e125d57964e0e47c781
https://doi.org/10.1016/s0924-8579(03)00180-8

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Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease

Autor: R. E. Sacco, D. E. Palmquist, Hongpeng Jia, Mohammad Heidari, Georgia K. Johnson, Paul B. McCray, Brian F. Tack, Janet M. Guthmiller, Kim A. Brogden

Publikováno v: Oral Microbiology and Immunology. 18:95-99

The severity of periodontal disease is dependent on a combination of host, microbial agent and environmental factors. One strong correlate related to periodontal disease pathogenesis is the immune status of the host. Here we show that human neutrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9a5f8b6327e239f96e569a32a84cd38
https://doi.org/10.1034/j.1399-302x.2003.00047.x

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The Solution Structures of the Human β-Defensins Lead to a Better Understanding of the Potent Bactericidal Activity of HBD3 against Staphylococcus aureus

Autor: Howard N. Hunter, Timothy D. Starner, Vladimir Aseyev, Brian F. Tack, Paul B. McCray, Hans J. Vogel, David J. Schibli, John M. Wiencek

Publikováno v: Journal of Biological Chemistry. 277:8279-8289

The three human beta-defensins, HBD1--3, are 33--47-residue, cationic antimicrobial proteins expressed by epithelial cells. All three proteins have broad spectrum antimicrobial activity, with HBD3 consistently being the most potent. Additionally, HBD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19214b092a6a255602c07683538a0401
https://doi.org/10.1074/jbc.m108830200

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SMAP-29 has two LPS-binding sites and a central hinge

Autor: William R. Kearney, Huiyuan Wu, Brian F. Tack, Alan J. Waring, Andrew D. Robertson, Wei Wang, Monali V. Sawai, Mark A. Sherman, Robert I. Lehrer, Teresa Hong, Lee Ming Boo

Publikováno v: European Journal of Biochemistry. 269:1181-1189

The CD spectra of SMAP-29, an antimicrobial peptide from sheep, showed disordered structure in aqueous buffers, and significant helicity in membrane-like environments, including SDS micelles, lipopolysaccharide (LPS) dispersions, and trifluoroethanol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee339b93b6a0610e37289ad224e68f7
https://doi.org/10.1046/j.0014-2956.2002.02751.x

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Orientation and Dynamics of an Antimicrobial Peptide in the Lipid Bilayer by Solid-State NMR Spectroscopy

Autor: Alan J. Waring, Robert I. Lehrer, Brian F. Tack, William R. Kearney, Mei Hong, Daniel Huster, Satoru Yamaguchi

Publikováno v: Biophysical Journal. 81:2203-2214

The orientation and dynamics of an 18-residue antimicrobial peptide, ovispirin, has been investigated using solid-state NMR spectroscopy. Ovispirin is a cathelicidin-like model peptide (NH(2)-KNLRRIIRKIIHIIKKYG-COOH) with potent, broad-spectrum bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301c9270503cf1b927069eeec6ef6fd9
https://doi.org/10.1016/s0006-3495(01)75868-7

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Cathelicidin Peptides Inhibit Multiply Antibiotic-Resistant Pathogens from Patients with Cystic Fibrosis

Autor: Timothy D. Starner, Brian F. Tack, Lisa Saiman, Patricia L. Winokur, Setareh Tabibi, Hongpeng Jia, Paul B. McCray, Pablo San Gabriel

Publikováno v: Antimicrobial Agents and Chemotherapy. 45:2838-2844

Endogenous peptide antibiotics are under investigation as inhaled therapeutic agents for cystic fibrosis (CF) lung disease. The bactericidal activities of five cathelicidin peptides (LL37 [human], CAP18 [rabbit], mCRAMP [mouse], rCRAMP [rat], and SMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becf59feb4951e037064bc1ad06c7719
https://doi.org/10.1128/aac.45.10.2838-2844.2001

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Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma

Autor: Rick A. Wetsel, Paul B. McCray, Scott M. Drouin, Brian F. Tack, Joie C. Haviland, Hong Pen Jia, Joseph Zabner, Jens Kildsgaard

Publikováno v: The Journal of Immunology. 166:2025-2032

The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress characterized by contraction of the smooth muscle walls in bronchioles and pulmonary arteries and aggregation of platelets and leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c0c2b817192dc575ba844a988d5b5e
https://doi.org/10.4049/jimmunol.166.3.2025

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The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection

Autor: Brian F. Tack, Paul B. McCray, D. E. Palmquist, Kim A. Brogden, Mark R. Ackermann, V. C. Kalfa

Publikováno v: Antimicrobial Agents and Chemotherapy. 45:331-334

Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9967381c9a29675188bb298599143584
https://doi.org/10.1128/aac.45.1.331-334.2001

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Abundant human β-defensin-1 expression in milk and mammary gland epithelium

Autor: Mark R. Ackermann, Paul B. McCray, Timothy D. Starner, Brian F. Tack, Hongpeng Jia, Patricia A. Kirby

Publikováno v: The Journal of Pediatrics. 138:109-112

Human β-defensin-1 (HBD-1) was detected in breast milk in concentrations of ~1 to 10 μg/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce78e607353d5a0fd5c65fb4f543f88
https://doi.org/10.1067/mpd.2001.109375

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