Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Brian F. Guida"'
Autor:
Mcmillan Lynette Jane, David J. Behm, Jian Jin, Kalindi Vaidya, Zining Wu, Michael J. Neeb, Dongchuan Shi, Karl F. Erhard, Feng Wang, Brian F. Guida, Sarah K. Lawrence, Christopher P. Evans, Stephen A. Douglas, Yonghui Wang, Ralph A. Rivero, Jyoti Disa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2860-2864
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-sp
Publikováno v:
International Journal of Cardiology. 108:31-35
Background Urotensin-II (U-II) is a vasoactive peptide with diffuse expression in human cardiomyocyte and vascular smooth muscle cells. Recent studies have reported increased plasma levels of U-II in patients with congestive heart failure. Objective
Autor:
Diane Naselsky, Brian F. Guida, Stephen A. Douglas, Frederick C. Kull, Jyoti Disa, Nambi Aiyar, David J. Behm, Zhaohui Ao, Jui-Lan Su
Publikováno v:
Peptides. 25(8)
Plasma and urinary levels of “urotensin(U)-II-like” substances determined in healthy human volunteers were 12.4 ± 0.6 ng/ml and 2.2 ± 0.3 ng/ml by RIA, an order of magnitude lower than that seen by RRA, 167.5 ± 9.5 ng/ml and 65.2 ± 4.3 ng/ml.