Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Brian Everatt"'
Autor:
Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 64:7241-7260
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fc619db3aa5e70b7fe14aeddd53fe
https://doi.org/10.1021/acs.jmedchem.1c00343
https://doi.org/10.1021/acs.jmedchem.1c00343
Autor:
Brian Cox, David C. Budd, Anna King, Gareth Williams, Nicholas Duggan, Rowan Stringer, Marcus Furegati, Alfred Schmidt, Josef G. Meingassner, Kamlesh Bala, Brian Everatt, Katharine L. Turner, Jennifer Simmons, Cerys Docx, Catherine Leblanc, Gerald Dubois, Frank Kalthoff, Caroline Wilson, Lucy Barker, Karen England, Nicola Arnold, John Westwick, Edward Charles Hall, Bindi Sohal, Jennifer Willis, Heinrich Aschauer, David Andrew Sandham, Rachael Profit, Zarin Brown, Lyndon Nigel Brown, Simon J. Watson, Jodie Manini, Christoph Walker, Matthew Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6582-6591
Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound NVP-QAV680 with low nM functional potency for inhibition of CRTh2 driven human eosinophil and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc63a5fbb90947c1f906a4739b943b4
https://doi.org/10.1016/j.bmc.2013.08.025
https://doi.org/10.1016/j.bmc.2013.08.025
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 54:722-729
High non-specific binding (NSB) is one of the most common reasons for candidate failure in potential positron emission tomography (PET) radiotracer development. It is of interest to develop high throughput in vitro methods for predicting non-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86386146716f90e97c8375d2d5f14f1c
https://doi.org/10.1016/j.jpba.2010.11.004
https://doi.org/10.1016/j.jpba.2010.11.004
Autor:
Clive Aldcroft, Zhengjin Jiang, Penny Wright, David Porter, Ian Clemens, Clayton Springer, Simon J. Watson, Robin Alec Fairhurst, Donnya Etheridge, Brian Everatt, Neil John Press, Brian Cox, John Reilly
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 34:317-327
A HPLC gradient methodology using immobilized human serum albumin (HSA) and rat serum albumin (RSA) has been used as a tool to investigate the protein binding trends of novel discovery compounds. These methods have been set up to support a high throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41ebfe593ad688dbe49da0f5871d56b
https://doi.org/10.1080/10826076.2011.548299
https://doi.org/10.1080/10826076.2011.548299
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 31:3132-3142
A new procedure for the determination of novel discovery drug substance purity was developed using LC-MS coupled with charged aerosol detection (CAD) in a walk up open access system and chromatographic purity service. Chemists require an accurate hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f635d4afadc7a8dca0eeabcc0c6122a
https://doi.org/10.1080/10826070802480081
https://doi.org/10.1080/10826070802480081
Autor:
Peter Taylor, Brian Everatt
Publikováno v:
PATAI'S Chemistry of Functional Groups ISBN: 9780470682531
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9a27a2b73548c26daeaf2bae1ae850
https://doi.org/10.1002/9780470682531.pat0006
https://doi.org/10.1002/9780470682531.pat0006
Publikováno v:
Journal of chromatography. A. 1216(12)
A novel porous zwitterionic monolith was prepared by thermal co-polymerisation of 2-methacryloyloxyethyl phosphorylcholine (MPC) and ethylene glycol dimethacrylate (EDMA) within 100 microm I.D. capillaries. Mercury intrusion porosimetry, scanning ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168b05b34f2fb6f950aa185b269de873
https://pubmed.ncbi.nlm.nih.gov/19178914
https://pubmed.ncbi.nlm.nih.gov/19178914
Publikováno v:
Electrophoresis. 29(17)
Lung tissue distribution of an inhaled drug is important for its potency in the airways and with minimum systemic effects within its dose range. As the lung has the smallest diffusion distance of all the organs in the body and negligible diffusion de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec18bbc8fb8d2ee0a64ebee9ec358144
https://pubmed.ncbi.nlm.nih.gov/18803182
https://pubmed.ncbi.nlm.nih.gov/18803182
Autor:
David C. Budd, David Bryan Harrison, Christopher Walker, Lucy Barker, Morris Tweed, Brian Everatt, Louise Bidlake, Rowan Stringer, Clive Aldcroft, Gurdip Bhalay, Catherine Leblanc, Emma Michelle Campbell, Urs Baettig, Simon J. Watson, Rachael Profit, Jennifer Willis, Gareth Williams, David Beer, Katharine L. Turner, Steven Whitebread, Zarin Brown, David Andrew Sandham, Gerald Dubois, Jodie Manini, Katy S Thompson, Brian Cox, Caroline Wilson
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368f8bff73f2b501c96315902c5c8fa
https://pubmed.ncbi.nlm.nih.gov/17531480
https://pubmed.ncbi.nlm.nih.gov/17531480