Výsledky vyhledávání - "Brian E. Toki"

Data from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates

Autor: Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Ivan J. Stone, Weiping Zeng, Kim K. Emmerton, Brian E. Toki, Kristine A. Gordon, Andrew B. Waight, Julia H. Cochran, Joshua H. Hunter, Jocelyn R. Setter, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke

A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody–drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy was exemp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01277dcf190fe027b1aa165ef0569aff
https://doi.org/10.1158/1535-7163.c.6538699.v1

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Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates

Autor: Patrick J. Burke, Ivan Stone, Julia H. Cochran, Peter D. Senter, Joshua H. Hunter, Brian E. Toki, Thomas A. Pires, Joseph Z. Hamilton, Jocelyn R. Setter, Scott C. Jeffrey, Kristine A. Gordon, Robert P. Lyon, Kim K. Emmerton, Andrew B. Waight, Weiping Zeng

Publikováno v: Molecular Cancer Therapeutics. 15:938-945

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cbdbff521e3af5c951cb2630d2231a
https://doi.org/10.1158/1535-7163.mct-16-0038

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Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation

Autor: Xinqun Zhang, Nicole M. Okeley, Scott C. Jeffrey, Patrick J. Burke, Stephen C. Alley, Peter D. Senter, Brian E. Toki

Publikováno v: Bioconjugate Chemistry. 24:1650-1655

The role that carbohydrates play in antibody function and pharmacokinetics has made them important targets for modification. The terminal fucose of the N-linked glycan structure, which has been shown to be involved in modulation of antibody-directed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356dd35556713b5b98a69339cbd026f7
https://doi.org/10.1021/bc4002695

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Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system

Autor: Kim M. Kissler, Patrick J. Burke, David W. Meyer, Jamie B. Miyamoto, Peter D. Senter, Brian E. Toki, Martha Anderson, Scott C. Jeffrey

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:2650-2653

Cytotoxic agents streptonigrin and 17-amino-geldanamycin were linked to monoclonal antibodies (mAbs), forming antibody-drug conjugates (ADCs) for antigen-mediated targeting to cancer cells. The drugs were conjugated with a linker construct that is la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871b4ac82717b11b8d5248f5cb3cc617
https://doi.org/10.1016/j.bmcl.2009.03.145

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Characterization of a CC49-Based Single-Chain Fragment−β-Lactamase Fusion Protein for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

Autor: Joshua Roy Basler, Lilia Babé, Peter D. Senter, Volker Schellenberger, Enrique Escandon, Ralph F. Alderson, Martin Roberge, Wei Geng, Brian E. Toki, Regina Chin, Roanna Ueda, Judith A. Fox, Tianling Chen, Amy Liu, Tessi Kanavarioti, Douglas Hodges

Publikováno v: Bioconjugate Chemistry. 17:410-418

CC49 is a clinically validated antibody with specificity for TAG-72, a carbohydrate epitope that is overexpressed and exposed on the cell surface in a large fraction of solid malignancies. We constructed a single-chain fragment (scFv) based on CC49 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240871119dc39749e0e8b1fb0c6a9c29
https://doi.org/10.1021/bc0503521

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Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery: Effects of Linker Technology on Efficacy and Toxicity

Autor: Brian A. Mendelsohn, and Alan F. Wahl, Ezogelin Oflazoglu, Russell J. Sanderson, Brian E. Toki, Damon L. Meyer, Charles G. Cerveny, Stephen C. Alley, Roger F. Zabinski, Svetlana O. Doronina, Peter D. Senter, Tim D. Bovee

Publikováno v: Bioconjugate Chemistry. 17:114-124

We have previously shown that antibody-drug conjugates (ADCs) consisting of cAC10 (anti-CD30) linked to the antimitotic agent monomethylauristatin E (MMAE) lead to potent in vitro and in vivo activities against antigen positive tumor models. MMAF is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397fcfeadaeb9ffdf49cc7ceecaceac8
https://doi.org/10.1021/bc0502917

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Protease-Mediated Fragmentation of p-Amidobenzyl Ethers: A New Strategy for the Activation of Anticancer Prodrugs

Autor: Brian E. Toki, and Alan F. Wahl, Charles G. Cerveny, Peter D. Senter

Publikováno v: The Journal of Organic Chemistry. 67:1866-1872

A new anticancer prodrug activation strategy based on the 1,6-elimination reaction of p-aminobenzyl ethers is described. Model studies were undertaken with the N-protected peptide benzyloxycarbonyl-valine-citrulline (Z-val-cit), which was attached to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203fff2c7d2df8679e6c7c4bcc943352
https://doi.org/10.1021/jo016187+

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