Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brian E. Oeffinger"'
Autor:
Raj Patel, Quezia Lacerda, Brian E. Oeffinger, John R. Eisenbrey, Ankit K. Rochani, Gagan Kaushal, Corinne E. Wessner, Margaret A. Wheatley
Publikováno v:
Polymers; Volume 14; Issue 8; Pages: 1568
Co-delivery of cancer therapeutics improves efficacy and encourages synergy, but delivery faces challenges, including multidrug resistance and spatiotemporal distribution of therapeutics. To address these, we added paclitaxel to previously developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81da77943053feb8eb4ae965f5bea48c
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 4, Pp 312-322 (2020)
Research in Pharmaceutical Sciences
Research in Pharmaceutical Sciences
Background and purpose: Lonidamine is a hexokinase II inhibitor, works as an anticancer molecule, and is extensively explored in clinical trials. Limited information prevails about the stability-indicating methods which could determine the forced deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b6c5bd1cfdd80d34fc6e6aad75123d
http://www.rpsjournal.net/article.asp?issn=1735-5362
http://www.rpsjournal.net/article.asp?issn=1735-5362
Autor:
Margaret A. Wheatley, John R. Eisenbrey, Brian E. Oeffinger, Purva B. Vaidya, Iman Ayaz, Rawan Shraim
Publikováno v:
Langmuir. 35:10068-10078
Ultrasound contrast agents consist of stabilized microbubbles. We are developing a surfactant-stabilized microbubble platform with a shell composed of Span 60 (Sorbitan monostearate) and an emulsifying agent, water-soluble vitamin E (α-tocopheryl po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d8d50f913b397c46bf4ed4052a34e3
https://doi.org/10.1021/acs.langmuir.8b03725
https://doi.org/10.1021/acs.langmuir.8b03725
Autor:
J.B. Liu, Maria Stanczak, Flemming Forsberg, David Brown, Lauren J Delaney, Masaya Jimbo, Jonathan R. Brody, Brian E. Oeffinger, Margaret A. Wheatley, John R. Eisenbrey
Publikováno v:
Acta Biomater
Ultrasound imaging presents many positive attributes, including safety, real-time imaging, universal accessibility, and cost. However, inherent difficulties in discrimination between soft tissues and tumors prompted development of stabilized microbub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53abb03e814ff82b19a870cd5f062ce9
https://pubmed.ncbi.nlm.nih.gov/34082100
https://pubmed.ncbi.nlm.nih.gov/34082100
Autor:
Patrick O'Kane, Flemming Forsberg, Gagan Kaushal, Margaret A. Wheatley, John R. Eisenbrey, Raj Patel, Brian E. Oeffinger, Quezia Lacerda, Ankit K. Rochani, Dennis B. Leeper
Publikováno v:
2020 IEEE International Ultrasonics Symposium (IUS).
Lonidamine (LND) has been widely explored due to its ability to target metabolic glycolysis and mitochondrial respiration in tumors [4]. However, clinical translation has stalled due to poor bioavailability after oral administration. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::978e8790b6278c362bf09bf6ecaab921
https://doi.org/10.1109/ius46767.2020.9251788
https://doi.org/10.1109/ius46767.2020.9251788
Autor:
Rawan Shraim, John R. Eisenbrey, Brian E. Oeffinger, Lauren J. Jablonowski, Scott W. Keith, Maria Stanczak, Patrick O'Kane, Jingzhi Li, Ji-Bin Liu, Dennis B. Leeper, Margaret A. Wheatley, Flemming Forsberg
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 101:88-96
Much of the volume of solid tumors typically exists in a chronically hypoxic microenvironment that has been shown to result in both chemotherapy and radiation therapy resistance. The purpose of this study was to use localized microbubble delivery to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc993dcc50dbc40ebf6771e5e757e511
https://doi.org/10.1016/j.ijrobp.2018.01.042
https://doi.org/10.1016/j.ijrobp.2018.01.042
Autor:
Margaret A. Wheatley, Jacob Powell, Quezia Lacerda, Purva B. Vaidya, Raj Patel, John R. Eisenbrey, Brian E. Oeffinger
Publikováno v:
Colloids Surf B Biointerfaces
We have developed oxygen filled microbubbles, SE61O2, for localized, ultrasound-triggered oxygen delivery to hypoxic tumors prior to radiation therapy. Microbubbles, created by sonication, have a shell composed of D-α-Tocopherol polyethylene glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfe9a2144a267b83e28262ac89dd6b7
https://doi.org/10.1016/j.colsurfb.2021.112049
https://doi.org/10.1016/j.colsurfb.2021.112049
Autor:
Kibo Nam, Patrick O'Kane, Dennis B. Leeper, Ji-Bin Liu, Brian E. Oeffinger, Flemming Forsberg, Mauricio J. Reginato, Margaret A. Wheatley, Jingzhi Li, Corinne E. Wessner, Lorela Ciraku, John R. Eisenbrey, Lauren J Delaney
OBJECTIVES—: Hypoxic cancer cells have been shown to be more resistant to radiation therapy than normoxic cells. Hence, this study investigated whether ultrasound (US)-induced rupture of oxygen-carrying microbubbles (MBs) would enhance the response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21a25200a0943e746d4e8aad0196967
https://europepmc.org/articles/PMC7064157/
https://europepmc.org/articles/PMC7064157/
Autor:
Maria Stanczak, Ji-Bin Liu, Patrick O'Kane, Margaret A. Wheatley, Jingzhi Li, John R. Eisenbrey, Rawan Shraim, Brian E. Oeffinger, Flemming Forsberg
Publikováno v:
2017 IEEE International Ultrasonics Symposium (IUS).
Tumor hypoxia has been shown to decrease the sensitivity of solid tumors to radiation. Systemic efforts to increase tumor oxygenation levels immediately prior to therapy, however, have largely proven unsuccessful. The objective of this work was to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4a2f78beee0dca68415c41e9fffeff
https://doi.org/10.1109/ultsym.2017.8092222
https://doi.org/10.1109/ultsym.2017.8092222
Publikováno v:
Ultrasound in medicinebiology. 32(1)
Ultrasound contrast agents (CA) are generally micron-sized stabilized gas bubbles, injected IV. However, to penetrate beyond the vasculature and accumulate in targets such as tumors, CA must be an order of magnitude smaller. We describe a method of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa64a477f41291e34725bdd54ecfca25
https://pubmed.ncbi.nlm.nih.gov/16364800
https://pubmed.ncbi.nlm.nih.gov/16364800