Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brian E. Nordin"'
Autor:
Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen
Publikováno v:
J Am Chem Soc
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9801b3a3bafd3e374259ca9ad1a1524
https://doi.org/10.1021/jacs.1c00990
https://doi.org/10.1021/jacs.1c00990
Autor:
Tsuyoshi Imasaki, Patrick Baumann, Claudine Bisson, Ashish Radadiya, Yuichiro Takagi, David W. Rice, Svetlana E. Sedelnikova, Nigel G. J. Richards, Adriana Coricello, Tyzoon K. Nomanbhoy, Alexandria H. Berry, Sabine Wenzel, John W. Kozarich, Yi Jin, Brian E. Nordin, Wen Zhu, Francisco Martínez-Márquez
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Communications Biology
Communications Biology
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a bona fide drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6e17ac46e2600532640cbb5658656
http://link.springer.com/article/10.1038/s42003-019-0587-z
http://link.springer.com/article/10.1038/s42003-019-0587-z
Autor:
Tyzoon K. Nomanbhoy, Sabine Wenzel, Alexandria H. Berry, Brian E. Nordin, Nigel G. J. Richards, Tsuyoshi Imasaki, David W. Rice, Claudine Bisson, Wen Zhu, Francisco Martínez-Márquez, Adriana Coricello, Patrick Baumann, Yuichiro Takagi, Ashish Radadiya, John W. Kozarich, Svetlana E. Sedelnikova, Yi Jin
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-1 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-1 (2019)
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7376b0d7f72c77cf8ba5e0a0098265f
https://doi.org/10.1038/s42003-019-0690-1
https://doi.org/10.1038/s42003-019-0690-1
Autor:
Christie L Eissler, Todd Kinsella, Gabe Simon, Colin Walsh, Joseph Klebba, Joel Chick, Ali Tabatabaei, Lena M Luukkonen, Landon Whitby, Kent T Symons, Kristen A. Baltgalvis, Yuta Naro, Matthew P. Patricelli, Larry Burgess, Dean Stamos, Joon Chang, Shota Kikuchi, Jaclyn Brannon, Charles Chapman, Brian E. Nordin
Publikováno v:
Cancer Research. 80:6411-6411
Introduction: Targeted protein degradation is a novel therapeutic modality that holds great promise. Current bispecific degraders have been mostly built using reversible ligands against two well characterized E3 ligases, CRBN and VHL. Features unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd8700abc857dc43915d725ae6b6f54
https://doi.org/10.1158/1538-7445.am2020-6411
https://doi.org/10.1158/1538-7445.am2020-6411
Autor:
Wen Zhu, Brian E. Nordin, John W. Kozarich, David W. Rice, Yi Jin, Svetlana E. Sedelnikova, Nigel G. J. Richards, Yuichiro Takagi, Sabine Wenzel, Claudine Bisson, Ashish Radadiya, Alexandria H. Berry, Patrick Baumann, Tsuyoshi Imasaki, Tyzoon K. Nomanbhoy
Expression of the enzyme human asparagine synthetase (ASNS) promotes metastatic progression in breast cancer, which affects L-asparagine levels and tumor cell invasiveness. Human ASNS has therefore emerged as abona fidedrug target for cancer therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278fe1ec095c7d5883329324ce978eb5
Autor:
Helge Weissig, Nathanael S. Gray, Chris Herring, Arwin Aban, David Zhou, Heidi E. Brown, Eric Okerberg, Subadhra Jagannathan, John W. Kozarich, Qingkai Yang, Jianming Zhang, Jiing Dwan Lee, Tyzoon K. Nomanbhoy, Jiangyue Wu, Brian E. Nordin, Matthew P. Patricelli
Publikováno v:
Chemistry & Biology. 18:699-710
Protein kinases are intensely studied mediators of cellular signaling, yet important questions remain regarding their regulation and in vivo properties. Here we use a probe-based chemoprotemics platform to profile several well studied kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf88204473b0d9c9c120755dfc9e3bd
https://doi.org/10.1016/j.chembiol.2011.04.011
https://doi.org/10.1016/j.chembiol.2011.04.011
Autor:
Steve J. Brown, Frank J. Schoenen, Peter Chase, Brian E. Nordin, Brian M. Stoltz, Dmitriy Minond, Amanda C. Jones, Hugh Rosen, Kelin Li, Tsui-Fen Chou, Patrick Porubsky, Peter Hodder, Raymond J. Deshaies, Matthew P. Patricelli
Publikováno v:
Proceedings of the National Academy of Sciences. 108:4834-4839
A specific small-molecule inhibitor of p97 would provide an important tool to investigate diverse functions of this essential ATPase associated with diverse cellular activities (AAA) ATPase and to evaluate its potential to be a therapeutic target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c223f363522a902a0174c1acbee8e9a
https://doi.org/10.1073/pnas.1015312108
https://doi.org/10.1073/pnas.1015312108
Autor:
Brian E. Nordin, Valérie de Crécy-Lagard, Benjamin J. Lyons, Paul Schimmel, James R. Williamson, Yulien Cruz, Basma El Yacoubi, Manal A. Swairjo, Robert Reddy, Fabio Agnelli
Publikováno v:
Nucleic Acids Research
Threonylcarbamoyladenosine (t(6)A) is a universal modification found at position 37 of ANN decoding tRNAs, which imparts a unique structure to the anticodon loop enhancing its binding to ribosomes in vitro. Using a combination of bioinformatic, genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462fedc0ed71f14b7d5755f39e5d6d52
http://europepmc.org/articles/PMC2685093
http://europepmc.org/articles/PMC2685093
Autor:
Anna Hainley, Jiangyue Wu, Brian E. Nordin, Tyzoon K. Nomanbhoy, Yongsheng Liu, Jonathan S. Rosenblum, Heidi E. Brown, Arwin Aban, John W. Kozarich
Publikováno v:
Biochemistry. 54(19)
Hsp90 is an ATP-dependent chaperone of widespread interest as a drug target. Here, using an LC-MS/MS chemoproteomics platform based on a lysine-reactive ATP acyl phosphate probe, several Hsp90 inhibitors were profiled in native cell lysates. Inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc3e6114285cf11b7c39bf07a902aa8
https://pubmed.ncbi.nlm.nih.gov/25905789
https://pubmed.ncbi.nlm.nih.gov/25905789
Autor:
Paul Schimmel, Brian E. Nordin
Publikováno v:
Biochemistry. 42:12989-12997
The genetic code depends on amino acid fine structure discrimination by aminoacyl-tRNA synthetases. For isoleucyl- (IleRS) and valyl-tRNA synthetases (ValRS), reactions that hydrolyze misactivated noncognate amino acids help to achieve high accuracy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c94bf4c5fd4127d9cc08f9a5454c069
https://doi.org/10.1021/bi035052q
https://doi.org/10.1021/bi035052q