Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian E. McIntosh"'
Autor:
Jue Zhang, Brian E. McIntosh, Bowen Wang, Matthew E. Brown, Mitchell D. Probasco, Sarah Webster, Bret Duffin, Ying Zhou, Lian-Wang Guo, William J. Burlingham, Craig Kent, Michael Ferris, James A. Thomson
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1269-1281 (2019)
Summary: Contractile to synthetic phenotypic switching of smooth muscle cells (SMCs) contributes to stenosis in vascular disease and vascular transplants. To generate more contractile SMCs, we performed a high-throughput differentiation screen using
Externí odkaz:
https://doaj.org/article/a6646e7a3e204df7957e528997a5ae08
Autor:
Matthew E. Brown, Ying Zhou, Brian E. McIntosh, Ian G. Norman, Hannah E. Lou, Mitch Biermann, Jeremy A. Sullivan, Timothy J. Kamp, James A. Thomson, Petros V. Anagnostopoulos, William J. Burlingham
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1175-1183 (2018)
Summary: Here, we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). Conventional humanized mouse models are made by engrafti
Externí odkaz:
https://doaj.org/article/081f57c2cd484249a05a76cb93c1caa6
Autor:
Kran Suknuntha, Yuki Ishii, Lihong Tao, Kejin Hu, Brian E. McIntosh, David Yang, Scott Swanson, Ron Stewart, Jean Y.J. Wang, James Thomson, Igor Slukvin
Publikováno v:
Stem Cell Research, Vol 15, Iss 3, Pp 678-693 (2015)
A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting fact
Externí odkaz:
https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd
Autor:
Brian E. McIntosh, Matthew E. Brown, Bret M. Duffin, John P. Maufort, David T. Vereide, Igor I. Slukvin, James A. Thomson
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 171-180 (2015)
In this study, we demonstrate a newly derived mouse model that supports engraftment of human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) strain with the C57BL/6J-KitW-41J/J (C57BL/
Externí odkaz:
https://doaj.org/article/2d630842a39c43368e62ccb99ba8c2eb
Autor:
David T. Vereide, Vernella Vickerman, Scott A. Swanson, Li-Fang Chu, Brian E. McIntosh, James A. Thomson
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 1043-1057 (2014)
During development, the hematopoietic and vascular lineages are thought to descend from common mesodermal progenitors called hemangioblasts. Here we identify six transcription factors, Gata2, Lmo2, Mycn, Pitx2, Sox17, and Tal1, that “trap” murine
Externí odkaz:
https://doaj.org/article/55957740db8c4e0aaae440ef1532b591
Autor:
Christopher Barry, Matthew T Schmitz, Cara Argus, Jennifer M Bolin, Mitchell D Probasco, Ning Leng, Bret M Duffin, John Steill, Scott Swanson, Brian E McIntosh, Ron Stewart, Christina Kendziorski, James A Thomson, Rhonda Bacher
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007543 (2019)
Pluripotent stem cells retain the developmental timing of their species of origin in vitro, an observation that suggests the existence of a cell-intrinsic developmental clock, yet the nature and machinery of the clock remain a mystery. We hypothesize
Externí odkaz:
https://doaj.org/article/14bcc2d6b0e84205bbe5dfa387cbcb92
Autor:
William J. Burlingham, Mitchell D. Probasco, Bret Duffin, James A. Thomson, Michael C. Ferris, Craig K. Kent, Sarah Webster, Bowen Wang, Brian E. McIntosh, Jue Zhang, Matthew E. Brown, Lian-Wang Guo, Ying Zhou
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1269-1281 (2019)
Summary: Contractile to synthetic phenotypic switching of smooth muscle cells (SMCs) contributes to stenosis in vascular disease and vascular transplants. To generate more contractile SMCs, we performed a high-throughput differentiation screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66b0740d6d2dca334894752a3c936fe
https://doi.org/10.1016/j.stemcr.2019.04.013
https://doi.org/10.1016/j.stemcr.2019.04.013
Autor:
Cara Argus, Michael Collins, Scott Swanson, Srikumar Sengupta, Bret Duffin, David U. Gorkin, James A. Thomson, Jennifer M. Bolin, Brian E. McIntosh, Ron Stewart, Li-Fang Chu, Morten Seirup, Zhang Cheng
Primary hepatocytes are widely used in the pharmaceutical industry to screen drug candidates for hepatotoxicity, but hepatocytes quickly dedifferentiate and lose their mature metabolic function in culture. Attempts have been made to better recapitula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8232df947ac7b16b9567ad17c889cb
https://doi.org/10.1101/2020.09.21.307363
https://doi.org/10.1101/2020.09.21.307363
Autor:
Scott Swanson, Christina Kendziorski, Brian E. McIntosh, Ning Leng, Bret Duffin, James A. Thomson, Ron Stewart, Jennifer M. Bolin, Cara Argus, Christopher Barry, Rhonda Bacher, Mitchell D. Probasco, John Steill, Matthew T. Schmitz
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007543 (2019)
PLoS Computational Biology
PLoS Computational Biology
Pluripotent stem cells retain the developmental timing of their species of origin in vitro, an observation that suggests the existence of a cell-intrinsic developmental clock, yet the nature and machinery of the clock remain a mystery. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd0a6f1fdceccde3c9050ac13ebd6e3
https://doaj.org/article/14bcc2d6b0e84205bbe5dfa387cbcb92
https://doaj.org/article/14bcc2d6b0e84205bbe5dfa387cbcb92
Autor:
Jennifer M. Bolin, Ron Stewart, William L. Murphy, Zhonggang Hou, Matthew T. Schmitz, Brian E. McIntosh, Bao K Nguyen, Christopher Barry, James A. Thomson, Scott Swanson, Mitchell D. Probasco, Michael P. Schwartz, Jue Zhang, Nicholas E. Propson, Peng Jiang
Publikováno v:
Experimental Biology and Medicine. 242:1679-1689
The aim of the present study was to test sample reproducibility for model neural tissues formed on synthetic hydrogels. Human embryonic stem (ES) cell-derived precursor cells were cultured on synthetic poly(ethylene glycol) (PEG) hydrogels to promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9294b5abbdbcac30352a22ef1eca5f8
https://doi.org/10.1177/1535370217715028
https://doi.org/10.1177/1535370217715028