Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Brian E. Krumm"'
1
Akademický článek
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
Autor: Kevin M. Knight, Brian E. Krumm, Nicholas J. Kapolka, W. Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G. Obarow, Tyler J. Lefevre, Wenyuan Wei, Ning Ma, Xi-Ping Huang, Jonathan F. Fay, Nagarajan Vaidehi, Alan V. Smrcka, Paul A. Slesinger, Diomedes E. Logothetis, Kirill A. Martemyanov, Bryan L. Roth, Henrik G. Dohlman
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Many neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associ
Externí odkaz: https://doaj.org/article/a1bbb4b8f5a447f79e49586a70a5bd73
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2
Akademický článek
Molecular mechanism of biased signaling at the kappa opioid receptor
Autor: Amal El Daibani, Joseph M. Paggi, Kuglae Kim, Yianni D. Laloudakis, Petr Popov, Sarah M. Bernhard, Brian E. Krumm, Reid H. J. Olsen, Jeffrey Diberto, F. Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O. Dror, Tao Che
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Externí odkaz: https://doaj.org/article/937c35a4ce1e4c9d8b16be30f0910f0c
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3
Akademický článek
Nanobody-enabled monitoring of kappa opioid receptor states
Autor: Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized stat
Externí odkaz: https://doaj.org/article/ea2f79e5cad94be58517658c2739cb15
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4
Ligand and G-protein selectivity in the κ-opioid receptor
Autor: Jianming Han, Jingying Zhang, Antonina L. Nazarova, Sarah M. Bernhard, Brian E. Krumm, Lei Zhao, Jordy Homing Lam, Vipin A. Rangari, Susruta Majumdar, David E. Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F. Fay, Tao Che
Publikováno v: Nature. 617:417-425
The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders1. However, the development of KOR analgesics has been hindered by the associated hallucinogenic side e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48195134013ae74e08dafaad877fee7d
https://doi.org/10.1038/s41586-023-06030-7
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8
Structural genomics of the human dopamine receptor system
Autor: Peiyu Xu, Sijie Huang, Brian E. Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xinheng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L. Roth, H. Eric Xu
Publikováno v: Cell Research.
The dopamine system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS) and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders, including Parkinson
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c0ae86e1e45b94ee0501a45ab889e8
https://doi.org/10.1038/s41422-023-00808-0
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9
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
Autor: Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
SUMMARYThe NTSR1 neurotensin receptor (NTSR1) is a G protein coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7f8f9a1b8e405f18eeb9bd5e4602a8f
https://doi.org/10.1101/2022.12.26.521971
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10
Structure, function and pharmacology of human itch GPCRs
Autor: Samuel T. Slocum, Yongfeng Liu, Bryan L. Roth, Jian Jin, Brian E. Krumm, Brian J. Bender, Reid H.J. Olsen, Hye Jin Kang, Justin G. English, Isha Singh, Jing Liu, Lily Yeh Jan, Wenlei Ye, Brian K. Shoichet, Xi Ping Huang, Byron W. Hayes, Can Cao, John D. McCorvy, Jonathan F. Fay, Katherine Lansu, Soman N. Abraham, Shicheng Zhang, Chengwei Zhang, Wesley K. Kroeze, Kuglae Kim, He Chen, Ryan H. Gumpper, Jeffrey F. DiBerto, Joel Karpiak
Publikováno v: Nature
Nature, vol 600, iss 7887
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e74bb609d8bd744fc782cf9ab54a3d
https://doi.org/10.1038/s41586-021-04126-6
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