Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brian E. Ford"'
Autor:
Amée M. Buziau, Maaike H. Oosterveer, Kristiaan Wouters, Trijnie Bos, Dean R. Tolan, Loranne Agius, Brian E. Ford, David Cassiman, Coen D.A. Stehouwer, Casper G. Schalkwijk, Martijn C.G.J. Brouwers
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101984- (2024)
Objective: Stable isotope studies have shown that hepatic de novo lipogenesis (DNL) plays an important role in the pathogenesis of intrahepatic lipid (IHL) deposition. Furthermore, previous research has demonstrated that fructose 1-phosphate (F1P) no
Externí odkaz:
https://doaj.org/article/f788e7cbbd6b437a8180795a7483cdf6
Autor:
Brian E. Ford, Shruti S. Chachra, Katrina Rodgers, Tabassum Moonira, Ziad H. Al-Oanzi, Quentin M. Anstee, Helen L. Reeves, Jörn M. Schattenberg, Rebecca J. Fairclough, David M. Smith, Dina Tiniakos, Loranne Agius
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101722- (2023)
Objectives: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associa
Externí odkaz:
https://doaj.org/article/bfd2b304f9c64daea275414d8bcedee8
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The Carbohydrate response element binding protein, ChREBP encoded by the MLXIPL gene, is a transcription factor that is expressed at high levels in the liver and has a prominent function during consumption of high-carbohydrate diets. ChREBP is activa
Externí odkaz:
https://doaj.org/article/979f97793fe5499f8041eed180798201
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3240 (2020)
Metformin therapy lowers blood glucose in type 2 diabetes by targeting various pathways including hepatic gluconeogenesis. Despite widespread clinical use of metformin the molecular mechanisms by which it inhibits gluconeogenesis either acutely throu
Externí odkaz:
https://doaj.org/article/12a616a1f18340648e0ade443a5920f8
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Frontiers in Endocrinology
Frontiers in Endocrinology
The Carbohydrate response element binding protein, ChREBP encoded by the MLXIPL gene, is a transcription factor that is expressed at high levels in the liver and has a prominent function during consumption of high-carbohydrate diets. ChREBP is activa
Autor:
David Baker, Loranne Agius, Celine Cano, Suzannah J. Harnor, Rebecca J Fairclough, Alfie Brennan, Brian E. Ford, Shruti S. Chachra, David M. Smith, Ahmed Alshawi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e90d6c07fc65ae63485a45d946240b
https://doi.org/10.1111/dom.14111/v2/response1
https://doi.org/10.1111/dom.14111/v2/response1
Autor:
Alfie Brennan, Loranne Agius, David Baker, Ahmed Alshawi, Brian E. Ford, Celine Cano, Suzannah J. Harnor, Rebecca J Fairclough, David M. Smith, Shruti S. Chachra
Publikováno v:
Diabetes, obesitymetabolismREFERENCES. 22(11)
Aim To test the hypothesis that glucokinase activators (GKAs) induce hepatic adaptations that alter intra-hepatocyte metabolite homeostasis. Methods C57BL/6 mice on a standard rodent diet were treated with a GKA (AZD1656) acutely or chronically. Hepa
Autor:
Ahmed Alshawi, Loranne Agius, Marc Foretz, Benoit Viollet, Silvia Marin, Natasha S. Adam-Primus, Shruti S. Chachra, Ziad H. Al-Oanzi, Tabassum Moonira, Marta Cascante, Catherine Arden, Brian E. Ford
Publikováno v:
The Journal of Biological Chemistry
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (10), pp.3330-3346. ⟨10.1074/jbc.ra120.012533⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (10), pp.3330-3346. ⟨10.1074/jbc.ra120.012533⟩
International audience; The chronic effects of metformin on liver gluconeogenesisinvolve repression of theG6pcgene, which is regulated by thecarbohydrate-response element–binding protein throughraised cellular intermediates of glucose metabolism. I
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3240, p 3240 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 3240, p 3240 (2020)
Metformin therapy lowers blood glucose in type 2 diabetes by targeting various pathways including hepatic gluconeogenesis. Despite widespread clinical use of metformin the molecular mechanisms by which it inhibits gluconeogenesis either acutely throu
Autor:
Thomas M. Zydowsky, Ninochka Jean-Pierre, Brian E. Ford, Ciby J. Abraham, Samantha Seidor, Larisa Kizima, Jennifer J. Peters, José A. Fernández-Romero, Aixa Rodriguez, Radhika Menon, Melissa Robbiani, Pedro Gil, David F. Katz, Othell Begay
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:358-368
Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carragu