Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian E. Chen"'
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Abnormal synaptic formation and signaling is one of the key molecular features of autism spectrum disorders (ASD). Cortactin binding protein 2 (CTTNBP2), an ASD-linked gene, is known to regulate the subcellular distribution of synaptic prote
Externí odkaz:
https://doaj.org/article/fae33c963254456a9433d10b11cccac7
Autor:
Kays I, Brian E Chen
Detecting when and how much a protein molecule is synthesized is important for understanding cell function, but current methods have poor cellular or temporal resolution or are destructive to cells (Dahm et al., 2008). Here, we developed a technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff51063c052050f3cbd981eb7aac86f
https://doi.org/10.1101/2021.06.27.450087
https://doi.org/10.1101/2021.06.27.450087
Publikováno v:
Journal of Biological Rhythms. 34:131-143
The circadian clock is an evolutionarily conserved mechanism that generates the rhythmic expression of downstream genes. The core circadian clock drives the expression of clock-controlled genes, which in turn play critical roles in carrying out many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08b9a439f4f6ac2b9844904bf5a42f0
https://doi.org/10.1177/0748730419830845
https://doi.org/10.1177/0748730419830845
Autor:
Brian E Chen, Ibrahim Kays
Publikováno v:
BioTechniques. 66:15-21
Single-cell analysis overcomes the problems of cellular heterogeneity by revealing the individual differences between cells in tissue. The current tools used to profile gene expression at the single-cell level are arduous and often require specialize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136160a1093758f7c81f1981c2c59bc
https://doi.org/10.2144/btn-2018-0130
https://doi.org/10.2144/btn-2018-0130
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Abnormal synaptic formation and signaling is one of the key molecular features of autism spectrum disorders (ASD). Cortactin binding protein 2 (CTTNBP2), an ASD-linked gene, is known to regulate the subcellular distribution of synaptic proteins, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6467c87ab52919d7b29cb5b40b5338
https://doi.org/10.1186/s40478-020-01053-x
https://doi.org/10.1186/s40478-020-01053-x
Autor:
Chiu-An Lo, Ibrahim Kays, Farida Emran, Hooman Bagheri, Xiang-Jiao Yang, Alan C. Peterson, Hana C. Friedman, Ellis Cooper, Katherine A. Siminovitch, Harry Shao, Yumaine Chong, Brian E. Chen
Publikováno v:
The CRISPR Journal
Precise genome editing using CRISPR typically requires delivery of guide RNAs, Cas9 endonuclease, and DNA repair templates. Both microinjection and electroporation effectively deliver these components into mouse zygotes provided the DNA template is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefe79d2dc5b6119cb806da216b4adb6
https://doi.org/10.1089/crispr.2017.0020
https://doi.org/10.1089/crispr.2017.0020
Publikováno v:
Molecular Brain
Molecular Brain, Vol 12, Iss 1, Pp 1-11 (2019)
Molecular Brain, Vol 12, Iss 1, Pp 1-11 (2019)
Proper axonal branch growth and targeting are essential for establishing a hard-wired neural circuit. Here, we examined the role of Fibroblast Growth Factor Receptors (FGFRs) in axonal arbor development using loss of function and overexpression genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122adfe867ad6bbfbb4d2639774cbf13
https://pubmed.ncbi.nlm.nih.gov/31651328
https://pubmed.ncbi.nlm.nih.gov/31651328
Autor:
Chiu-An Lo, Brian E Chen
Publikováno v:
Developmental biology. 454(1)
Allelic expression from each parent-of-origin is important as a backup and to ensure that enough protein products of a gene are produced. Thus far, it is not known how each cell throughout a tissue differs in parental allele expression at the level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ac7cf8d0dd63555d8d5a8e1ab167fe
https://pubmed.ncbi.nlm.nih.gov/31194972
https://pubmed.ncbi.nlm.nih.gov/31194972
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2634-2644 (2015)
SummaryAccurate measurement of the amount of specific protein a cell produces is important for investigating basic molecular processes. We have developed a technique that allows for quantitation of protein levels in single cells in vivo. This protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6c1e6a38d8c3207c4b32d7e2609afe
http://www.sciencedirect.com/science/article/pii/S2211124715013637
http://www.sciencedirect.com/science/article/pii/S2211124715013637