Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Brian E. Cathers"'
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
Supplementary Figures S1-S3, Tables S1-S7. Suppl. Figure S1: Prolif. Curves, PC3 Cell Cycle & solid tumor apoptosis Suppl. Figure S2: PK/PD Model Performance and eIF4E In Vivo Biomarker Suppl. Figure S3: HCT-116, MBA MD231 & A549 Efficacy Studies Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1
https://doi.org/10.1158/1535-7163.22500843.v1
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1
https://doi.org/10.1158/1535-7163.c.6536589.v1
Autor:
Kobina Dufu, Carsten Alt, Steven Strutt, James Partridge, Tzechiang Tang, Vincent Siu, Hilary Liao‐Zou, Peter Rademacher, Alexander T. Williams, Cynthia R. Muller, Xin Geng, Mira Patel Pochron, Annie Nguyen Dang, Pedro Cabrales, Zhe Li, Donna Oksenberg, Brian E. Cathers
Publikováno v:
British Journal of Haematology.
Autor:
Kate Blease, Garth Ringheim, Eduardo Torres, Jeffrey Muir, Laurie LeBrun, Veronique Plantevin-Krenitsky, Ashutosh Kulkarni, Maria Celeridad, Eun Mi Hur, Hegde Sayee Gajanan, Dehua Huang, Brian E. Cathers, John Sapienza, Henry Chan, Brydon Bennett, Katerina Leftheris, Correa Matthew D, Zheng Liu, Deborah S Mortensen, Brandon Whitefield, Mercedes Delgado, Dan Cashion, Sogole Bahmanyar, Lisa Morrison, Roli Khattri, Jason Parnes, Stephen Norris, Roy Harris, Kelven Burnett, Joshua Hansen, Godrej Khambatta, Patrick Papa
Publikováno v:
Journal of Medicinal Chemistry. 64:11886-11903
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines su
Autor:
Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales
Publikováno v:
Blood. 140:5377-5378
Autor:
Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales
Publikováno v:
Blood. 140:5375-5376
Autor:
Correa Matthew D, Rama K. Narla, Laurie LeBrun, Joshua Hansen, Antonia Lopez-Girona, John Sapienza, Brian E. Cathers, Gang Lu, Joseph R Piccotti, Weihong Zhang, Ammirante Massimo, Matt Alexander, Nagy Mark A, Dehua Huang, Yang Tang, Michael Pourdehnad
Publikováno v:
Journal of Medicinal Chemistry. 64:1835-1843
Acute myeloid leukemia (AML) is marked by significant unmet clinical need due to both poor survival and high relapse rates where long-term disease control for most patients with relapsed or refractory AML remain dismal. Inspired to bring novel therap
Autor:
Joshua Hansen, John E. Dick, Philip P Chamberlain, Emily Rychak, Gang Lu, In Sock Jang, Jean C.Y. Wang, Thomas Clayton, Celia Fontanillo, Derek Mendy, Michael Pourdehnad, Jinhong Fan, Stanley W.K. Ng, Eileen Tran, Mark Rolfe, Nathan Mbong, Kai Wang, Chin-Chun Lu, James Carmichael, Christine Surka, Mary E Matyskiela, Daniel W. Pierce, Mark D. Minden, Liqing Jin, Antonia Lopez-Girona, Brian E. Cathers, Elizabeth Anne Tindall, Adrian Contreras, Christy Hsu
Publikováno v:
Blood. 137:661-677
A number of clinically validated drugs have been developed by repurposing the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex with molecular glue degraders to eliminate disease-driving proteins. Here, we present the identification of a fir
Autor:
Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:6648-6676
Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to t
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice
Autor:
Brian E. Cathers, Allyn M. Eaker, Kobina Dufu, Donna Oksenberg, Carsten Alt, Cynthia M. Walser, Cynthia R. Muller, Pedro Cabrales, Alexander T. Williams, Alfredo Lucas
Publikováno v:
Am J Physiol Heart Circ Physiol
Therapeutic agents that increase the Hb affinity for oxygen (O(2)) could, in theory, lead to decreased O(2) release from Hb and impose a hypoxic risk to tissues. In this study, GBT1118, an allosteric modifier of Hb affinity for O(2), was used to asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fac07ff5e44e3b39232d2d3cb06f5a2
https://europepmc.org/articles/PMC8410120/
https://europepmc.org/articles/PMC8410120/