Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Brian E Sansbury"'
Autor:
Ada Weinstock, Karishma Rahman, Or Yaacov, Hitoo Nishi, Prashanthi Menon, Cyrus A Nikain, Michela L Garabedian, Stephanie Pena, Naveed Akbar, Brian E Sansbury, Sean P Heffron, Jianhua Liu, Gregory Marecki, Dawn Fernandez, Emily J Brown, Kelly V Ruggles, Stephen A Ramsey, Chiara Giannarelli, Matthew Spite, Robin P Choudhury, P'ng Loke, Edward A Fisher
Publikováno v:
eLife, Vol 10 (2021)
Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation. Using Il4-/-Il13-/- mice, resolution was impaired,
Externí odkaz:
https://doaj.org/article/c161388cdc5a4ae69a76b07070902db1
Autor:
Robert N Helsley, Venkateshwari Varadharajan, Amanda L Brown, Anthony D Gromovsky, Rebecca C Schugar, Iyappan Ramachandiran, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase K Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J Osborn, William Massey, Renliang Zhang, Anagha Kadam, Brian E Sansbury, Calvin Pan, Jessica Sacks, Richard G Lee, Rosanne M Crooke, Mark J Graham, Madeleine E Lemieux, Valentin Gogonea, John P Kirwan, Daniela S Allende, Mete Civelek, Paul L Fox, Lawrence L Rudel, Aldons J Lusis, Matthew Spite, J Mark Brown
Publikováno v:
eLife, Vol 8 (2019)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver di
Externí odkaz:
https://doaj.org/article/f9448bea0b9e426ea0147da3a9110b3e
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
An increase in calorie consumption is associated with the recent rise in obesity prevalence. However, our current understanding of the effects of nutrient excess on major metabolic pathways appears insufficient to develop safe and effective metabolic
Externí odkaz:
https://doaj.org/article/3e2e5692d7994931a5a64c11a159377c
Autor:
Elizabeth S. Levy, PhD, Alexander S. Kim, MD, Evan Werlin, MD, Mian Chen, MD, Brian E. Sansbury, PhD, Matthew Spite, PhD, Tejal A. Desai, PhD, Michael S. Conte, MD
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100126- (2023)
Background: Specialized pro-resolving lipid mediators (SPM) such as resolvin D1 (RvD1) attenuate inflammation and exhibit vasculo-protective properties. Methods: We investigated poly-lactic-co-glycolic acid (PLGA)-based nanoparticles (NP), containing
Externí odkaz:
https://doaj.org/article/5eca84e79d3f4d969f439f662eaf7fe3
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Scientific advancement is predicated upon the ability of a novel discovery to be independently reproduced and substantiated by others. Despite this inherent necessity, the research community is awash in published studies that cannot be replicated res
Externí odkaz:
https://doaj.org/article/7b4c6fa0fcd545babc8b0f86b872ed83
Autor:
Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osório Leiria, Matthew Spite, Yu-Hua Tseng
Publikováno v:
Nature Metabolism. 4:775-790
Obesity induces chronic inflammation resulting in insulin resistance and metabolic disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the mechanisms have not been fully elucidated. Here, we find that cold resolves obe
Autor:
Xianlin Han, Meixia Pan, Brian E. Sansbury, Andrew R. Reeves, Andrew S. Greenberg, Matthew Spite
Publikováno v:
The Journal of Immunology. 207:2744-2753
In response to infection or tissue damage, resident peritoneal macrophages (rpMACs) produce inflammatory lipid mediators from the polyunsaturated fatty acid (PUFA), arachidonic acid (AA). Long-chain acyl-CoA synthetase 4 (ACSL4) catalyzes the covalen
Autor:
Haley Asplund, Petra Haberzettl, Jason Hellmann, Daniel J Conklin, Steven Jones, Aruni Bhatnagar, Brian E Sansbury
Publikováno v:
Circulation Research. 131
Chronic exposure to ambient particulate matter (PM) increases the risk of cardiovascular disease (CVD). One proposed mechanism linking PM exposure and CVD is the induction of low-grade systemic inflammation that underlies disease progression. However
Autor:
Jeffrey S. Berger, James W. Canary, Bianca Scolaro, Christina C. Rolling, Hanane El Bannoudi, Edward A. Fisher, Brian E. Sansbury, Ada Weinstock, Shiyu Chen, Matthew Spite, Sean P. Heffron, Tessa J. Barrett, Greg Marecki
Publikováno v:
J Thromb Haemost
BACKGROUND Platelets are increasingly recognized as immune cells. As such, they are commonly seen to induce and perpetuate inflammation; however, anti-inflammatory activities are increasingly attributed to them. Atherosclerosis is a chronic inflammat
Autor:
Michael J. Zhang, Andreas Patsalos, Blenda Wong, Laszlo Nagy, Brian E. Sansbury, Nikolas Giannakis, Xiaofeng Li, Matthew Spite
Publikováno v:
Proc Natl Acad Sci U S A
Ischemic injury initiates a sterile inflammatory response that ultimately participates in the repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery during ischemia, in part because they produce growth factors that a