Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Brian E, Hsu"'
Autor:
Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, Peter M. Siegel
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103276- (2024)
Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously
Externí odkaz:
https://doaj.org/article/9541bdda466b464aac43f308bd0b1d8e
Autor:
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate
Externí odkaz:
https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neutrophils are the first leukocytes recruited to sites of inflammation, where they execute anti-microbial functions to eliminate infectious agents. These functions include phagocytosis, release of reactive oxygen species and the formation of neutrop
Externí odkaz:
https://doaj.org/article/c16c03820f734e02b849dde53d60d491
Autor:
Brian E. Hsu, Sébastien Tabariès, Radia M. Johnson, Sylvia Andrzejewski, Julien Senecal, Camille Lehuédé, Matthew G. Annis, Eric H. Ma, Sandra Völs, LeeAnn Ramsay, Remi Froment, Anie Monast, Ian R. Watson, Zvi Granot, Russell G. Jones, Julie St-Pierre, Peter M. Siegel
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3902-3915.e6 (2019)
Summary: Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver
Externí odkaz:
https://doaj.org/article/25f477ee241a49fb82076fe716b1a056
Autor:
Victor W Ho, Elyse Hofs, Ingrid Elisia, Vivian Lam, Brian E Hsu, June Lai, Beryl Luk, Ismael Samudio, Gerald Krystal
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168072 (2016)
In previous studies we found that macrophages (MФs) from SH2-containing inositol-5'-phosphatase (SHIP) deficient mice are M2 polarized while their wild type (WT) counterparts are M1 polarized and that this difference in MФ phenotype can be recapitu
Externí odkaz:
https://doaj.org/article/52e9c200b73448b2829d2553730093e0
Autor:
Peter M. Siegel, Ian R. Watson, Matthew G. Annis, Santiago Costantino, Brian E. Hsu, LeeAnn Ramsay, Jonathan Spicer, Joannie Roy, Roni F. Rayes, Jack G. Mouhanna, Sébastien Tabariès
Publikováno v:
Oncogene. 39:2612-2623
Neutrophils represent the immune system’s first line of defense and are rapidly recruited into inflamed tissue. In cancer associated inflammation, phenotypic heterogeneity has been ascribed to this cell type, whereby neutrophils can manifest anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f7ac4a8e9a9a7f091a5d20f42a13c1
https://doi.org/10.1038/s41388-020-1169-8
https://doi.org/10.1038/s41388-020-1169-8
Autor:
Marco Biondini, Alex Kiepas, Leeanna El-Houjeiri, Matthew G. Annis, Brian E. Hsu, Anne-Marie Fortier, Geneviève Morin, José A. Martina, Isabelle Sirois, Adriana Aguilar-Mahecha, Tina Gruosso, Shawn McGuirk, April A. N. Rose, Unal M. Tokat, Radia M. Johnson, Ozgur Sahin, Eric Bareke, Julie St-Pierre, Morag Park, Mark Basik, Jacek Majewski, Rosa Puertollano, Arnim Pause, Sidong Huang, Tibor Keler, Peter M. Siegel
Publikováno v:
Oncogene
Transmembrane glycoprotein NMB (GPNMB) is a prognostic marker of poor outcome in patients with triple-negative breast cancer (TNBC). Glembatumumab Vedotin, an antibody drug conjugate targeting GPNMB, exhibits variable efficacy against GPNMB-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f0bdd5267b564ab173e5a49392f4ac
https://hdl.handle.net/11693/111385
https://hdl.handle.net/11693/111385
Autor:
Mathieu Lajoie, Ryuhjin Ahn, Jesse Hudson, Ian R. Watson, Sébastien Tabariès, Peter M. Siegel, Eduardo Cepeda Cañedo, Rachel La Selva, Claire M. Brown, Julien Senecal, Valerie Sabourin, Josie Ursini-Siegel, Matthew J. Siegel, Elena Voorand, Brian E. Hsu, Matthew Dankner, Alex Kiepas, Kyle Lewis, Jacqueline R. Ha, Matthew G. Annis
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f1f183a688a8be5016364492f4c75
https://doi.org/10.1186/s13058-020-1245-6
https://doi.org/10.1186/s13058-020-1245-6
Autor:
Anita Hall, Russell G. Jones, A. Metcalfe-Roach, Lindsay DeVorkin, Luciana Tonelli, Bozena Samborska, Radia M. Johnson, Said Izreig, Breanna R. Flynn, Maya C. Poffenberger, Eric H. Ma, Alison H-T Wong, George Zogopoulos, Ekaterina Loginicheva, P. Kim, Simon-Pierre Gravel, Brian E. Hsu, Maxim N. Artyomov, N. Beauchemin, Julian J. Lum, Jocelyn Chen, Esther Aguilar, Julianna Blagih, Peter M. Siegel
Publikováno v:
Science. 361:406-411
Inflammation promotes gut polyposis Peutz–Jeghers Syndrome (PJS) causes benign polyps in the gut and a higher risk of several cancers caused by mutations in the tumor suppressor gene STK11 , which encodes liver kinase B1 (LKB1). LKB1's role in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f85f04bbc05e681c54d573f50c892
https://doi.org/10.1126/science.aan3975
https://doi.org/10.1126/science.aan3975
Autor:
Josie Ursini-Siegel, Brian E. Hsu, Ryuhjin Ahn, Peter M. Siegel, Matthew G. Annis, April A.N. Rose
Publikováno v:
Cancer Immunology Research. 8:B88-B88
The role of glycoprotein-NMB (GPNMB) in the immune system is varied. GPNMB expression in macrophages and dendritic cells promotes innate immune responses, whereas GPNMB-expressing myeloid-derived suppressor (MDSC) cells suppress adaptive immune respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30128c077747bbbf646fb3ef94dc3273
https://doi.org/10.1158/2326-6074.tumimm19-b88
https://doi.org/10.1158/2326-6074.tumimm19-b88