Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brian Dobosh"'
Autor:
Brian Dobosh, Keivan Zandi, Diego Moncada Giraldo, Shu Ling Goh, Kathryn Musall, Milagros Aldeco, Julia LeCher, Vincent D. Giacalone, Junkai Yang, Devon J. Eddins, Manoj Bhasin, Eliver Ghosn, Vikas Sukhatme, Raymond F. Schinazi, Rabindra Tirouvanziam
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110945- (2022)
Summary: SARS-CoV-2-infected subjects are generally asymptomatic during initial viral replication but may suffer severe immunopathology after the virus has receded and monocytes have infiltrated the airways. In bronchoalveolar lavage fluid from sever
Externí odkaz:
https://doaj.org/article/ea7bd0ec72344e9d92d16f88c63dabad
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100892- (2021)
Summary: Neutrophils are difficult to study, particularly in tissues, due to their short half-life and propensity for activation. We describe an organotypic airway model that uses patient airway fluid to enable the transmigration of blood neutrophils
Externí odkaz:
https://doaj.org/article/a18880fe04d04f668d20c3de25909a88
Autor:
Camilla Margaroli, Diego Moncada-Giraldo, Dalia Arafat Gulick, Brian Dobosh, Vincent D. Giacalone, Osric A. Forrest, Fangxu Sun, Chunhui Gu, Amit Gaggar, Haydn Kissick, Ronghu Wu, Greg Gibson, Rabindra Tirouvanziam
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100239- (2021)
Summary: Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. He
Externí odkaz:
https://doaj.org/article/330b3a1590594f2eba3bc5803c699101
Autor:
Osric A Forrest, Brian Dobosh, Sarah A Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A Alvarez, Milton R Brown, Vin Tangpricha, Rabindra Tirouvanziam
Publikováno v:
Journal of leukocyte biologyREFERENCES. 112(4)
Cystic fibrosis (CF) airways feature high extracellular levels of the IL-1 family of proinflammatory mediators. These mediators are cleavage products of caspase-1, the final protease in the inflammasome cascade. Due to the proven chronic presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d34ac5d1ac81a8776325ee67053d4
https://pubmed.ncbi.nlm.nih.gov/35172381
https://pubmed.ncbi.nlm.nih.gov/35172381
Autor:
Camilla Margaroli, Diego Moncada Giraldo, Dalia Arafat Gulick, Brian Dobosh, Vincent Giacalone, Osric Forrest, Fangxu Sun, Chunhui Gu, Haydn Kissick, Ronghu Wu, Greg Gibson, Rabindra Tirouvanziam
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eab9bf7f03e12411aa75687ca81bc30c
https://doi.org/10.2139/ssrn.3543838
https://doi.org/10.2139/ssrn.3543838
Autor:
Niek N. Sanders, Katie Bodner, Tyler E Wagner, Oliwia Andries, Brian Dobosh, Tasuku Kitada, Jacob R. Becraft, Jacob Beal, Xin Zhang, Amanda Woo, Douglas Densmore, Ron Weiss, Bremy Alburquerque, Porter Ely Blanton, Brian Teague
Publikováno v:
Nature Chemical Biology. 14:1043-1050
Synthetic mRNA is an attractive vehicle for gene therapies because of its transient nature and improved safety profile over DNA. However, unlike DNA, broadly applicable methods to control expression from mRNA are lacking. Here we describe a platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a7442dfe8e39c3fab2f7d15212be01
https://doi.org/10.1038/s41589-018-0146-9
https://doi.org/10.1038/s41589-018-0146-9
Autor:
Murillo Silva, Elise Landais, Ron Weiss, Brian Dobosh, Mariane B. Melo, Alessia Liguori, William R. Schief, David Nemazee, Sergey Menis, Porter Ely Blanton, Devin Sok, Na Li, Darrell J. Irvine, Yuan Zhang, Pat Skog
Publikováno v:
Mol Ther
Elsevier
Elsevier
Self-replicating RNAs derived from alphaviruses have high potential for vaccine applications. Utilizing lipid nanoparticle-formulated RNA replicons as a vaccine platform to deliver self-assembling protein immunogens, Melo et al. demonstrate robust an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755d108ecaef6cd9c8909e4d55bd6de4
https://europepmc.org/articles/PMC6904793/
https://europepmc.org/articles/PMC6904793/
Autor:
Camilla Margaroli, Diego Moncada Giraldo, Dalia Arafat-Gulick, Brian Dobosh, Vincent Giacalone, Haydn Kissick, Osric A Forrest, Chunhui Gu, Gregory Gibson, Rabindra M Tirouvanziam
Publikováno v:
The Journal of Immunology. 204:148.39-148.39
Rationale Neutrophils are often considered the first line of defense against bacterial infections. In cystic fibrosis (CF), massive neutrophil presence is concomitant with phenotypical changes and prolonged bacterial infections. Here, we sought to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70b1279dec182a64bc4628622ec5670
https://doi.org/10.4049/jimmunol.204.supp.148.39
https://doi.org/10.4049/jimmunol.204.supp.148.39
Autor:
Zhijun Su, Porter Ely Blanton, Brian Teague, Yuan Zhang, Brian Dobosh, Tyler E Wagner, Darrell J. Irvine, Yingzhong Li, Ron Weiss
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3aa35d905334c62e226b62d7d062ad1
https://pubmed.ncbi.nlm.nih.gov/31061426
https://pubmed.ncbi.nlm.nih.gov/31061426
Publikováno v:
The Journal of Immunology. 202:183.15-183.15
Rationale Patients with cystic fibrosis (CF) present a large amount of respiratory damage caused in large part by chronic neutrophil influx into the lung. Neutrophils recruited to the lumen of the CF lung actively exocytose neutrophil elastase (NE) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46345481b0452ed5ac8c4927e032e4be
https://doi.org/10.4049/jimmunol.202.supp.183.15
https://doi.org/10.4049/jimmunol.202.supp.183.15