Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers?

Autor: Brian DellaValle, Alba Manresa-Arraut, Henrik Hasseldam, Allan Stensballe, Jørgen Rungby, Agnete Larsen, Casper Hempel

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

IntroductionMultiple sclerosis (MS) is a devastating autoimmune disease, afflicting people in the prime of their lives. Presently, after initial clinical presentation, there are no reliable markers for whether a patient will develop MS, or whether th

Externí odkaz: https://doaj.org/article/c2f175ffbc9f486b82b42a3320915616

Glucagon-like peptide-1 analogue, liraglutide, delays onset and reduces severity of experimental autoimmune encephalitis in Lewis rats

Autor: Brian DellaValle, Gitte Brix, Birgitte Brock, Michael Gejl, Anne Landau, Arne Møller, Jørgen Rungby, Agnete Larsen

Publikováno v: Frontiers in Pharmacology, Vol 7 (2016)

AbstractIntroduction: Recent findings indicate that metabolic disturbances are involved in multiple sclerosis (MS) pathology and influence the susceptibility to treatment, directing attention towards anti-diabetic drugs such as metformin and pioglita

Externí odkaz: https://doaj.org/article/083461103e4c4a4f807294cf612f0ead

Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology

Autor: Rasmus Rydbirk, Ole Østergaard, Jonas Folke, Casper Hempel, Brian DellaValle, Thomas L. Andresen, Annemette Løkkegaard, Anne-Mette Hejl, Matthias Bode, Morten Blaabjerg, Mette Møller, Erik H. Danielsen, Lisette Salvesen, Charlotte C. Starhof, Sara Bech, Kristian Winge, Jørgen Rungby, Bente Pakkenberg, Tomasz Brudek, Jesper V. Olsen, Susana Aznar

Publikováno v: Rydbirk, R, Østergaard, O, Folke, J, Hempel, C, DellaValle, B, Andresen, T L, Løkkegaard, A, Hejl, A M, Bode, M, Blaabjerg, M, Møller, M, Danielsen, E H, Salvesen, L, Starhof, C C, Bech, S, Winge, K, Rungby, J, Pakkenberg, B, Brudek, T, Olsen, J V & Aznar, S 2022, ' Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology ', Cellular and Molecular Life Sciences, vol. 79, no. 6, 336 . https://doi.org/10.1007/s00018-022-04378-z

Background: Multiple system atrophy (MSA) is a rare, progressive, neurodegenerative disorder presenting glia pathology. Still, disease etiology and pathophysiology are unknown, but neuro-inflammation and vascular disruption may be contributing factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414588e6e93161d2374b6b53847171d7
https://pure.au.dk/portal/da/publications/brain-proteome-profiling-implicates-the-complement-and-coagulation-cascade-in-multiple-system-atrophy-brain-pathology(b8cd5ea5-42d8-44af-9892-0c9cb28de11d).html

Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats

Autor: Agnete Larsen, Birgitte Brock, Gitte S. Brix, Brian DellaValle, Michael Gejl, Anne M. Landau, Jørgen Rungby, Arne Møller

Publikováno v: Della Valle, B W, Brix, G S, Brock, B, Gejl, M, Landau, A M, Moller, A, Rungby, J & Larsen, A 2016, ' Glucagon-like peptide-1 analog, Liraglutide, delays onset of experimental autoimmune encephalitis in Lewis rats ', Frontiers in Pharmacology, vol. 7, 433 . https://doi.org/10.3389/fphar.2016.00433
Frontiers in Pharmacology
DellaValle, B, Brix, G S, Brock, B, Jensen, M G, Landau, A M, Møller, A, Rungby, J & Larsen, A 2016, ' Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats ', Frontiers in Pharmacology, vol. 7, pp. 433 . https://doi.org/10.3389/fphar.2016.00433

Introduction: Recent findings indicate that metabolic disturbances are involved in multiple sclerosis (MS) pathology and influence the susceptibility to treatment, directing attention toward anti-diabetic drugs such as metformin and pioglitazone. Lir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d914b1164b94e3927886febc885e5cb0

Implementation of minimally invasive and objective humane endpoints in the study of murine Plasmodium infections

Autor: Filip C. Castberg, Jørgen A. L. Kurtzhals, Brian DellaValle, J. Kirchhoff, Lasse Maretty

Publikováno v: Parasitology.

SUMMARYDefining appropriate and objective endpoints for animal research can be difficult. Previously we evaluated and implemented a body temperature (BT) of Plasmodium bergheiANKA infection in C57Bl/6 mice. SMA was induced withPlasmodium chabaudiAS i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bb4982185945d76957ca660fcb837a
https://pubmed.ncbi.nlm.nih.gov/24993593