Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Brian Dean"'
Autor:
Sanjida Mir, Ryan J. Keenan, Romke Bron, Cameron J. Nowell, Catriona McLean, Leah C. Beauchamp, Laura J. Vella, Brian Dean, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100202- (2024)
Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the distribution of receptors in the brain can inform their function and guide targeting of specific d
Externí odkaz:
https://doaj.org/article/9f4c6bbb7e4a49a9a8786c108d2f560f
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S643- (2023)
Externí odkaz:
https://doaj.org/article/144abeb159a34e0599bc6a660951cfeb
Autor:
Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This i
Externí odkaz:
https://doaj.org/article/f1ec9a45070b44f8919ec5e999afb01f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/9880b097eb214535bda2932943546074
Autor:
Brian Dean, Geor Bakker, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the
Externí odkaz:
https://doaj.org/article/17f6b5e38bfb42699304842dee624e12
Autor:
Brian Dean, Elizabeth Scarr
Publikováno v:
npj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors (CHRM1) in patients with schizophrenia which is significant because CHRM signalling has been shown to change levels of gene expression and cortical gene
Externí odkaz:
https://doaj.org/article/f5d1a6cc2fbf49c198d455a4481819e1
Autor:
Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto‐Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-24 (2019)
Abstract Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as‐yet‐unknown pathophysiologies of schizophrenia, we undertook proteom
Externí odkaz:
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4
Publikováno v:
Non-Coding RNA, Vol 6, Iss 3, p 33 (2020)
The similarities between the depressive symptoms of Major Depressive Disorders (MDD) and Bipolar Disorders (BD) suggest these disorders have some commonality in their molecular pathophysiologies, which is not apparent from the risk genes shared betwe
Externí odkaz:
https://doaj.org/article/c50c21dad4444e41a2b1fde30ac75af6
Autor:
Sarah S. Ch’ng, Adam J. Walker, Madeleine McCarthy, Thien-Kim Le, Natalie Thomas, Andrew Gibbons, Madhara Udawela, Snezana Kusljic, Brian Dean, Andrea Gogos
Publikováno v:
Brain Sciences, Vol 10, Iss 2, p 106 (2020)
Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This s
Externí odkaz:
https://doaj.org/article/01a0c1fb30344551a8fdd8e5fb903d3b
Publikováno v:
Non-Coding RNA, Vol 4, Iss 2, p 11 (2018)
Schizophrenia is associated with diverse changes in the brain’s transcriptome and proteome. Underlying these changes is the complex dysregulation of gene expression and protein production that varies both spatially across brain regions and temporal
Externí odkaz:
https://doaj.org/article/fed10f960a594ebc8867feafcb40c3d5