Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Brian D. Zoltowski"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 2 (2015)
The Light-Oxygen-Voltage domain family of proteins is widespread in biology where they impart sensory responses to signal transduction domains. The small, light responsive LOV modules offer a novel platform for the construction of optogenetic tools.
Externí odkaz:
https://doaj.org/article/b7cbc09839fd4e4392018982f849a118
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010794 (2022)
Signal Transducer and Activator of Transcription 3 (STAT3) plays a crucial role in cancer development and thus is a viable target for cancer treatment. STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) domain, a key t
Externí odkaz:
https://doaj.org/article/9330d525e6bc44c6a2c8c7a083cb93b1
Autor:
Francesco Trozzi, Nischal Karki, Zilin Song, Niraj Verma, Elfi Kraka, Brian D. Zoltowski, Peng Tao
Publikováno v:
Org Biomol Chem
The Angiotensin Converting Enzyme 2 (ACE2) assists the regulation of blood pressure and is the main target of the coronaviruses responsible for SARS and COVID19. The catalytic function of ACE2 relies on the opening and closing motion of its peptidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b045a3e2ec4c4d18e1d18f5b60e7d69b
https://pubmed.ncbi.nlm.nih.gov/35420112
https://pubmed.ncbi.nlm.nih.gov/35420112
Autor:
Ashutosh Pudasaini, Jae Sung Shim, Young Hun Song, Hua Shi, Takatoshi Kiba, David E Somers, Takato Imaizumi, Brian D Zoltowski
Publikováno v:
eLife, Vol 6 (2017)
A LOV (Light, Oxygen, or Voltage) domain containing blue-light photoreceptor ZEITLUPE (ZTL) directs circadian timing by degrading clock proteins in plants. Functions hinge upon allosteric differences coupled to the ZTL photocycle; however, structural
Externí odkaz:
https://doaj.org/article/63df3c18425d46d2ad0ec1a914335ec3
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124874 (2015)
Light Oxygen Voltage (LOV) proteins are widely used in optogenetic devices, however universal signal transduction pathways and photocycle mechanisms remain elusive. In particular, short-LOV (sLOV) proteins have been discovered in bacteria and fungi,
Externí odkaz:
https://doaj.org/article/7d2326d12db342f8b970ce59193a404f
Publikováno v:
Protein Sci
Cryptochromes (CRYs) function as blue light photoreceptors in diverse physiological processes in nearly all kingdoms of life. Over the past several decades they have emerged as the most likely candidates for light-dependent magnetoreception in animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79c0d0637661dbfc7cc82ef102570ca
https://europepmc.org/articles/PMC8284579/
https://europepmc.org/articles/PMC8284579/
Autor:
Carla B. Green, Nischal Karki, Wei Xu, Anushka Wickramaratne, Ryan E. Hibbs, Yogarany Chelliah, P. J. Hore, Henrik Mouritsen, Lauren E. Jarocha, Joseph S. Takahashi, Brian D. Zoltowski
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Seasonal migration is dependent on an organism being able to sense and reorient to the Earth’s magnetic field. Cryptochromes (CRYs) have been implicated as light-driven sensors of the Earth’s magnetic field; however, contradictions b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b4ffe9da7434012f2c561d4557caac
https://doi.org/10.1073/pnas.1907875116
https://doi.org/10.1073/pnas.1907875116
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1573, p 1573 (2021)
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1392, p 1392 (2021)
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1573, p 1573 (2021)
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1392, p 1392 (2021)
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A concerted effort from research labs around the world resulted in the identification of potential pharmaceutical treatments for CoVID-19 using existing drugs, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74317f245ff085daff205767e3b143cd
Autor:
Ashutosh Pudasaini, Abby Blumenfeld, Nischal Karki, Robert Green, Brian D. Zoltowski, Young Hun Song, Takato Imaizumi
Plants measure light, quality, intensity, and duration to coordinate growth and development with daily and seasonal changes in environmental conditions, however, the molecular details linking photochemistry to signal transduction remain incomplete. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ed0be3a747ac1d530554a0665b66d1
https://doi.org/10.1101/2020.10.05.326595
https://doi.org/10.1101/2020.10.05.326595
Publikováno v:
J Phys Chem B
The conformational-driven allosteric protein diatom Phaeodactylum tricornutum aureochrome 1a (PtAu1a) di ers from other light-oxygen-voltage (LOV) proteins for its uncommon structural topology. The mechanism of signaling transduction in PtAu1a LOV do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e685bc61c79b8b180b1d80468418e0
https://doi.org/10.26434/chemrxiv.12575954
https://doi.org/10.26434/chemrxiv.12575954