Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Brian D. Rudd"'
Publikováno v:
Immunological Reviews. 315:108-125
Autor:
Zachary T. Hilt, Wisler Charles, Katarina E. Cheng, Cybelle Tabilas, Megan Steinhilber, Samantha P. Wesnak, Norah L. Smith, Chris B. Schaffer, Brian D. Rudd
Publikováno v:
The Journal of Immunology. 209:2281-2286
CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing
Autor:
Dahihm Kim, Luye An, Jiwon Moon, Viviana I. Maymi, Alexander I. McGurk, Brian D. Rudd, Deborah Fowell, Andrew C. White
Publikováno v:
Cancer Research.
Therapies targeting oncogene addiction have had a tremendous impact on tumor growth and patient outcome, but drug resistance continues to be problematic. One approach to deal with the challenge of resistance entails extending anti-cancer treatments b
Autor:
Neva B. Watson, Ravi K. Patel, Oyebola O. Oyesola, Nathan Laniewski, Jennifer K. Grenier, Jocelyn Wang, Cybelle Tabilas, Kristel J. Yee Mon, Seth P. Peng, Samantha P. Wesnak, Kito Nzingha, Norah L. Smith, Miles P. Davenport, Elia D. Tait Wojno, Kristin M. Scheible, Andrew Grimson, Brian D. Rudd
The immune system is stratified into layers of specialized cells with distinct functions. Recently, Lin28b was shown to serve as a master regulator of fetal lymphopoiesis, programming the development of more innate-like lymphocytes in early life. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::592a5d6671425f467f14b5deddfc6402
https://doi.org/10.1101/2022.02.14.480406
https://doi.org/10.1101/2022.02.14.480406
Publikováno v:
Trends Immunol
The fate-mapping mouse has become an essential tool in the immunologist's toolbox. Although traditionally used by developmental biologists to trace the origins of cells, immunologists are turning to fate-mapping to better understand the development a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cdaf7c814bd8dbe35a915264bdb466
https://europepmc.org/articles/PMC8882138/
https://europepmc.org/articles/PMC8882138/
Autor:
Brian D. Rudd, Cybelle Tabilas, Norah L. Smith, Xiaojing Liu, Jocelyn Wang, Jason W. Locasale
Publikováno v:
The Journal of Immunology. 203:2571-2576
Neonates often develop poor immunity against intracellular pathogens. Because CD8+ T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstra
Autor:
Cybelle Tabilas, Brian D. Rudd, Arnold Reynaldi, Timothy E. Schlub, Miles P. Davenport, Vanessa Venturi, Norah L. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3974-3981
Accumulating evidence indicates that the immune system does not develop in a linear fashion, but rather as distinct developmental layers formed from sequential waves of hematopoietic stem cells, each giving rise to unique populations of immune cells
Autor:
Minh T.N. Le, Norah L. Smith, Ravi K. Patel, Hongya Zhu, Kristin Scheible, Luyen Tien Vu, Brian D. Rudd, Ciarán W.P. Daly, Andrew Grimson, Kondwani C. Jambo, David J. Topham, Kristel J. Yee Mon
Publikováno v:
Cell reports. 37(6)
Summary MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential ex
Autor:
Brian D Rudd, Vanessa Venturi, Norah L Smith, Kito Nzingha, Emily L Goldberg, Gang Li, Janko Nikolich-Zugich, Miles P Davenport
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003572 (2013)
Microbial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in the immune compartment and functional immunity remain unclear. The ability of the immune system t
Externí odkaz:
https://doaj.org/article/d9280fa4da4d457289cba4be95de1ff8
Autor:
Brian D. Rudd
Publikováno v:
Annu Rev Immunol
Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or defective. However, recent studies prompt a reinterpretation of the functions of neonatal T cells. Rather than a population of cells always falling short of expectatio