Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brian D. Ratnasinghe"'
Autor:
Neshatul Haque, Tomoki Kawai, Brian D. Ratnasinghe, Jessica B. Wagenknecht, Raul Urrutia, Luigi D. Notarangelo, Michael T. Zimmermann
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108040- (2023)
Summary: Interpreting genetic changes observed in individual patients is a critical challenge. The array of immune deficiency syndromes is typically caused by genetic variation unique to individuals. Therefore, new approaches are needed to interpret
Externí odkaz:
https://doaj.org/article/99029b4d95e64cc3971cf8da11e65139
Autor:
Brian D. Ratnasinghe, Neshatul Haque, Jessica B. Wagenknecht, Davin R. Jensen, Guadalupe K. Valdivia Esparza, Elise N. Leverence, Thiago Milech De Assuncao, Angela J. Mathison, Gwen Lomberk, Brian C. Smith, Brian F. Volkman, Raul Urrutia, Michael T. Zimmermann
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4790-4803 (2023)
Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases.
Externí odkaz:
https://doaj.org/article/e4afc6f4318146d9b1881bfb9d51d6e8
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0313308 (2024)
Artificial Intelligence (AI)-based deep learning methods for predicting protein structures are reshaping knowledge development and scientific discovery. Recent large-scale application of AI models for protein structure prediction has changed percepti
Externí odkaz:
https://doaj.org/article/34de9df51c2640ad90bc53550460e489
Publikováno v:
Journal of Chemical Information and Modeling. 60:6476-6488
G-quadruplexes (GQs) are topologically diverse, highly thermostable noncanonical nucleic acid structures that form in guanine-rich sequences in DNA and RNA. GQs are implicated in transcriptional and translational regulation and genome maintenance, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa97246802fbee178abbe2a5ebb8236
https://doi.org/10.1021/acs.jcim.0c01064
https://doi.org/10.1021/acs.jcim.0c01064
Publikováno v:
Biophysical Journal. 120:222a-223a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c34c73eb0e6798ec22952fbdeea4cd6d
https://doi.org/10.1016/j.bpj.2020.11.1489
https://doi.org/10.1016/j.bpj.2020.11.1489
Publikováno v:
Biophysical Journal. 118:224a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c41d432abb6230815c881eb6159630
https://doi.org/10.1016/j.bpj.2019.11.1329
https://doi.org/10.1016/j.bpj.2019.11.1329
Publikováno v:
Biophysical Journal. 116:359a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7386c3c3bdeb20365828fda202391f
https://doi.org/10.1016/j.bpj.2018.11.1954
https://doi.org/10.1016/j.bpj.2018.11.1954