Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brian D. Quinlan"'
Autor:
Lizhou Zhang, Kunal R. More, Amrita Ojha, Cody B. Jackson, Brian D. Quinlan, Hao Li, Wenhui He, Michael Farzan, Norbert Pardi, Hyeryun Choe
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but sever
Externí odkaz:
https://doaj.org/article/7b70659bd0904a95a8cbe3fb1aab2982
Autor:
Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614
Externí odkaz:
https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb
An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines
Autor:
Yan Guo, Wenhui He, Huihui Mou, Lizhou Zhang, Jing Chang, Shoujiao Peng, Amrita Ojha, Rubens Tavora, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan, Brian D. Quinlan
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
All available vaccines for coronavirus disease 2019 (COVID-19) express or deliver the full-length SARS-CoV-2 spike (S) protein. We show that this antigen is not optimal, consistent with observations that the vast majority of the neutralizing response
Externí odkaz:
https://doaj.org/article/6183610d6fb446c1b899921bc6de5b56
Autor:
Yuka Otsuka, Kimberly Schmitt, Brian D Quinlan, Matthew R Gardner, Barnett Alfant, Adrian Reich, Michael Farzan, Hyeryun Choe
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007238 (2018)
Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapi
Externí odkaz:
https://doaj.org/article/a8160b611bce49b6a7b475f9f83d8f83
Autor:
Pabalu Karunadharma, Brian D. Quinlan, Yan Guo, Mai H. Tran, Yiming Yin, Meredith E. Davis-Gardner, Tianling Ou, Haimin Wang, Xia Zhang, Michael Farzan, Guocai Zhong, HaJeung Park, Wenhui He
Publikováno v:
Mol Ther
B cells have been engineered ex vivo to express an HIV-1 broadly neutralizing antibody (bNAb). B-cell reprograming may be scientifically and therapeutically useful, but current approaches limit B-cell repertoire diversity and disrupt the organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461e82cbaba74179dcba6f75a50cf71c
https://europepmc.org/articles/PMC8753427/
https://europepmc.org/articles/PMC8753427/
Publikováno v:
Proc Natl Acad Sci U S A
Three variable 2 (V2) loops of HIV-1 envelope glycoprotein (Env) trimer converge at the Env apex to form the epitope of an important classes of HIV-1 broadly neutralizing antibodies (bNAbs). These V2-glycan/apex antibodies are exceptionally potent bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad575017fb4e439e3fa40710bfbc097
https://pubmed.ncbi.nlm.nih.gov/34261793
https://pubmed.ncbi.nlm.nih.gov/34261793
Autor:
Guojie Zhong, Yanhai Yin, Yan Guo, Haimin Wang, Xiaoyu Zhang, Michael Farzan, Pabalu Karunadharma, Brian D. Quinlan, HaJeung Park, Tianling Ou, Mai H. Tran, Wan-ting He, Meredith E. Davis-Gardner
B cells have been engineered ex vivo to express an HIV-1 broadly neutralizing antibody (bNAb). B-cell reprograming may be scientifically and therapeutically useful, but current approaches limit B-cell repertoire diversity and disrupt the organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d8702a4b89f401626562123ff22ff99
https://doi.org/10.1101/2021.04.01.437943
https://doi.org/10.1101/2021.04.01.437943
Autor:
Lizhou Zhang, Michaela U. Gack, Charles C. Bailey, GuanQun Liu, Meredith E. Davis-Gardner, Huihui Mou, Hyeryun Choe, Christoph Rader, Zhi Xiang Voo, Haiyong Peng, Michael D. Alpert, Gogce Crynen, Michael Farzan, Matthew R. Gardner, Shoujiao Peng, Lindsey B. DeVaux, Brian D. Quinlan, Yan Guo
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009501 (2021)
PLoS Pathogens
bioRxiv
article-version (status) pre
article-version (number) 1
PLoS Pathogens
bioRxiv
article-version (status) pre
article-version (number) 1
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that eme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba257fb110ab5f74b0edaa482f0ee052
https://doaj.org/article/98e83cef2acb4c9d893d3ecb82c4b632
https://doaj.org/article/98e83cef2acb4c9d893d3ecb82c4b632
Autor:
Anthony Griffiths, Rebecca I. Johnson, Sophia Rits-Volloch, Michael Farzan, Nadia Storm, Hanqin Peng, Brian D. Quinlan, Bing Chen, Jianming Lu, Tianshu Xiao, Shen Lu, Jun Zhang, Michael S. Seaman, Lindsay G. A. McKay, Christy L. Lavine, Yongfei Cai
Publikováno v:
Nature Structural & Molecular Biology
Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase that forms a dimer and serves as the cellular receptor for severe acute respirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4c01259f53fa134e5f4876b7a366bb
An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines
Autor:
Lizhou Zhang, Guangxiang Luo, Mark S. Parcells, Hyeryun Choe, Shoujiao Peng, Brian D. Quinlan, Amrita Ojha, Wenhui Li, Guocai Zhong, Rubens Tavora, Wenhui He, Yan Guo, Michael Farzan, Huihui Mou, Jing Chang
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
mBio, Vol 12, Iss 3 (2021)
mBio
article-version (status) pre
article-version (number) 1
mBio, Vol 12, Iss 3 (2021)
mBio
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates viral entry into cells expressing angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ef2534ab0a8621bad46dbc79a6a5f6
http://europepmc.org/articles/PMC7685318
http://europepmc.org/articles/PMC7685318