Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brian D. Lamon"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159130 (2016)
There is emerging evidence identifying microRNAs (miRNAs) as mediators of statin-induced cholesterol efflux, notably through the ATP-binding cassette transporter A1 (ABCA1) in macrophages. The objective of this study was to assess the impact of an HM
Externí odkaz:
https://doaj.org/article/02427ad663024f2bad9dd9b2084fb02a
Autor:
Cynthia Cheung, Tal Nuriel, Ruba S. Deeb, Brian D. Lamon, Barbara D. Summers, Steven S. Gross, David P. Hajjar
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H687-H698
Protein 3-nitrotyrosine (3-NT) formation is frequently regarded as a simple biomarker of disease, an irreversible posttranslational modification that can disrupt protein structure and function. Nevertheless, evidence that protein 3-NT modifications m
Autor:
Nader G. Abraham, Yilun Zhang, Sumit R Monu, Brian D. Lamon, Alberto Nasjletti, Fan Zhang, Nitin Puri, Lars Bellner, Komal Sodhi
Publikováno v:
Antioxidants & Redox Signaling. 18:471-480
Aims: Hydrogen peroxide (H2O2), a nonradical oxidant, is employed to ascertain the role of redox mechanisms in regulation of vascular tone. Where both dilation and constriction have been reported, we examined the hypothesis that the ability of H2O2 t
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159130 (2016)
PLoS ONE
PLoS ONE
There is emerging evidence identifying microRNAs (miRNAs) as mediators of statin-induced cholesterol efflux, notably through the ATP-binding cassette transporter A1 (ABCA1) in macrophages. The objective of this study was to assess the impact of an HM
Publikováno v:
Current Hypertension Reviews. 5:273-282
The endothelium generates powerful mediators that regulate blood flow, temper inflammation and maintain a homeostatic environment to prevent both the initiation and progression of vascular disease. Nitric oxide (NO) is arguably the single most influe
Autor:
Brian D. Lamon, Nitin Puri, Sergey V. Brodsky, Frank Zhang, Alberto Nasjletti, Michael S. Goligorsky
Publikováno v:
Circulation Research. 105:775-783
Rationale : Vascular tissues produce carbon monoxide (CO) via HO-dependent and HO-independent mechanisms; the former in tandem with biliverdin and iron and the latter as a lone product. CO has been shown to function as both a vasoconstrictor and vaso
Publikováno v:
European Journal of Pharmacology. 606:72-76
Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of p
Autor:
David P. Hajjar, Brian D. Lamon
Publikováno v:
The American Journal of Pathology. 173:1253-1264
Despite the multifactorial nature of atherosclerosis, substantial evidence has established inflammation as an often surreptitious, yet critical and unifying driving force which promotes disease progression. To this end, research has defined molecular
Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice
Autor:
Brian D. Lamon, David P. Hajjar, Rita K. Upmacis, Ruba S. Deeb, Katherine A. Hajjar, Hao Shen, Lea Esther S. Benguigui
Nitric oxide (NO) is an important vasoactive molecule produced by three NO synthase (NOS) enzymes: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS). While eNOS contributes to blood vessel dilation that protects against the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafe00894c7311bf6c9bfdea96aeb210
https://europepmc.org/articles/PMC3154673/
https://europepmc.org/articles/PMC3154673/
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 299(3)
Cyclooxygenase (COX)-2 and inducible nitric oxide (NO) synthase (iNOS) are responsive to a wide array of inflammatory stimuli, have been localized to vascular smooth muscle cells (SMCs), and are intimately linked to the progression of vascular diseas