Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brian D. Hitt"'
Autor:
Brian D. Hitt, Jaime Vaquer-Alicea, Victor A. Manon, Joshua D. Beaver, Omar M. Kashmer, Jan N. Garcia, Marc I. Diamond
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-10 (2021)
Abstract Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homogenates has been quantified wit
Externí odkaz:
https://doaj.org/article/26fecdf55fb444eaa83ce6638c777ea8
Autor:
Brian D. Hitt, Ankit Gupta, Ruhar Singh, Ting Yang, Joshua D. Beaver, Ping Shang, Charles L. White, Lukasz A. Joachimiak, Marc I. Diamond
Neurodegenerative tauopathies are caused by transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick disease (PiD). We have pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7de0dc6def623f02a4e14630ba23b8
https://doi.org/10.1101/2023.05.04.539475
https://doi.org/10.1101/2023.05.04.539475
Autor:
Brian D Hitt, Ting Yang, Joshua D. Beaver, Ping Shang, Lukasz A Joachimiak, Charles White, Marc Diamond
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Victor A. Manon, Marc I. Diamond, Jaime Vaquer-Alicea, Omar M. Kashmer, Joshua D. Beaver, Jan N. Garcia, Brian D. Hitt
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-10 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homogenates has been quantified with “bios
Autor:
Michael S. LaCroix, Brian D. Hitt, Joshua D. Beaver, Sandi-Jo Estill-Terpack, Kelly Gleason, Carol A. Tamminga, Bret M. Evers, Charles L. White, Marc I. Diamond
Neurodegenerative tauopathies such as Alzheimer’s disease (AD) are caused by brain accumulation of tau assemblies. Evidence suggests tau functions as a prion, and cells and animals efficiently propagate unique tau assemblies. This suggests a dedica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0c25803a5160402bb127ffaac14b4a
https://doi.org/10.1101/2022.02.03.479049
https://doi.org/10.1101/2022.02.03.479049
Autor:
Kim N. Green, Brian D. Hitt, Yama Akbari, Ian F. Smith, Angelo Demuro, Frank M. LaFerla, Ian Parker
Publikováno v:
The Journal of Cell Biology
Green, KN; Demuro, A; Akbari, Y; Hitt, BD; Smith, IF; Parker, I; et al.(2008). SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production. Journal of Cell Biology, 181(7), 1107-1116. doi: 10.1083/jcb.200706171. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1489j8qc
Green, KN; Demuro, A; Akbari, Y; Hitt, BD; Smith, IF; Parker, I; et al.(2008). SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production. Journal of Cell Biology, 181(7), 1107-1116. doi: 10.1083/jcb.200706171. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1489j8qc
In addition to disrupting the regulated intramembraneous proteolysis of key substrates, mutations in the presenilins also alter calcium homeostasis, but the mechanism linking presenilins and calcium regulation is unresolved. At rest, cytosolic Ca2+ i
Autor:
M. Paul Murphy, Brian D. Hitt, Nabil N. Dagher, Yama Akbari, Bertrand P. Tseng, Kim N. Green, Frank M. LaFerla, Todd E. Golde
Publikováno v:
Biochemical and Biophysical Research Communications. 322:1145-1152
Mutations in presenilin-1 and 2 (PS) lead to increased intracellular calcium stores and an attenuation in the refilling mechanism known as capacitative calcium entry (CCE). Previous studies have shown that the mechanism by which PS modulates intracel
Publikováno v:
Journal of neurochemistry. 94(6)
Alzheimer's disease (AD) is the most prevalent form of dementia among the elderly and is a complex disorder that involves altered proteolysis, oxidative stress and disruption of ion homeostasis. Animal models have proven useful in studying the impact
Autor:
M. Paul Murphy, Todd E. Golde, Yama Akbari, Salvatore Oddo, J. Ashot Kozak, Nabil N. Dagher, Brian D. Hitt, Frank M. LaFerla, Bert Tseng, Michael D. Cahalan, Malcolm A. Leissring
Publikováno v:
Neurobiology of Aging. 25:S154-S155