Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Brian D. Guth"'
Autor:
Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Alexandre J. S. Ribeiro, Tanja Zabka, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclini
Externí odkaz:
https://doaj.org/article/e6b42e00ab1d407c9c50c66883fb0686
Autor:
Alexandre J. S. Ribeiro, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provid
Externí odkaz:
https://doaj.org/article/2e22341d9929407fb056d39646d70fe3
It is a description of our laboratory experience over the past 30 years in cardiovascular telemetry studies for safety pharmacology studies at Boehringer-Igelheim.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::5f64482204d8a9cf4ec9f4da255dd9fa
https://zenodo.org/record/8064648
https://zenodo.org/record/8064648
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221763 (2019)
We compared a published computational model of the action potential of a specific type of human induced pluripotent stem cell -derived cardiomyocytes (hiPSC-CM) with experimental field potential data with regard to their inter-beat interval and the d
Externí odkaz:
https://doaj.org/article/011be1e24cf3433ca21dfbf9cce6728b
Autor:
Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Werner Mayer, Katrin Christ, Eric Martel, Brian D. Guth, Michael Markert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. :107279
Autor:
Alexandre J S, Ribeiro, Brian D, Guth, Michael, Engwall, Sandy, Eldridge, C Michael, Foley, Liang, Guo, Gary, Gintant, John, Koerner, Stanley T, Parish, Jennifer B, Pierson, Mathew, Brock, Khuram W, Chaudhary, Yasunari, Kanda, Brian, Berridge
Publikováno v:
Frontiers in Pharmacology
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provid
Autor:
Michael K. Pugsley, Brian D. Guth
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 87:24-26
The pivotal role of safety pharmacology in the safety testing of new drugs is now well established, having received a large impetus through the regulatory requirement of this type of study and the appearance of the ICHS7A guidance in 2001 (US FDA, 20
Autor:
David J. Gallacher, Gary Gintant, Najah Abi-Gerges, Mark R. Davies, Hua Rong Lu, Kimberly M. Hoagland, Georg Rast, Brian D. Guth, Hugo M. Vargas, Robert L. Hamlin
This chapter highlights various non-automated classical in vitro techniques used today to evaluate drug effects on cardiac electrophysiology. It then outlines a three-pronged preclinical initiative called the Comprehensive In Vitro Proarrhythmia Assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e2e962b10a51d57981680e00049c57
https://doi.org/10.1002/9781119053248.ch9
https://doi.org/10.1002/9781119053248.ch9
Publikováno v:
Circulation Research. 73:869-886
Increased heart rate and left ventricular pressure during humoral and neuronal adrenergic activation act to restrict blood flow preferentially in the subendocardium. The hypothesis was advanced that alpha-adrenergic coronary vasoconstriction preferen
Autor:
T. Miura, Shunichi Miyazaki, Valmik Bhargava, Brian D. Guth, Ciro Indolfi, Katharina S. Sunnerhagen, Kirk L. Peterson
Publikováno v:
Europe PubMed Central
To clarify whether impaired left ventricular relaxation elicited by increased afterload is attributable to regional dyssynchrony, we analyzed in dogs simultaneous left ventricular contrast ventriculography and pressure before and during angiotensin I