Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brian D. Bower"'
Publikováno v:
Aging Cell
Summary Interventions that extend lifespan in mice can show substantial sexual dimorphism. Here, we show that male‐specific lifespan extension with two pharmacological treatments, acarbose (ACA) and 17‐α estradiol (17aE2), is associated, in male
Autor:
Jack D. Griffith, Brian D. Bower
Publikováno v:
Biochemistry
A growing body of literature suggests that the homologous recombination/repair (HR) pathway cooperates with components of the shelterin complex to promote both telomere maintenance and nontelomeric HR. This may be due to the ability of both HR and sh
Autor:
Susan V. Brooks, Danielle C. Leander, Oliver Fiehn, Brian D. Bower, Sharlene M. Day, Michael Garratt, Kaitlyn Pifer, Jonathan J. Herrera, Richard A. Miller
Publikováno v:
Aging Cell
Aging cell, vol 18, iss 2
Aging cell, vol 18, iss 2
Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexes. 17-α estradiol (17aE2), a less feminizing structural isomer of 17-β estradiol, produces lifespan extension only in male mice, suggesting a sexual
Autor:
Robert J. Gorelick, Kevin M. Weeks, Brent M. Znosko, Jason D. Lieb, Jacob K. Grohman, Brian D. Bower, Colin R. Lickwar
Publikováno v:
Science. 340:190-195
RNA chaperones are ubiquitous, heterogeneous proteins essential for RNA structural biogenesis and function. We investigated the mechanism of chaperone-mediated RNA folding by following the time-resolved dimerization of the packaging domain of a retro
Autor:
John J. Kopchick, Brian D. Bower, Elahu S. Gosney, Darlene E. Berryman, Edward O. List, S. Okada, Juan Ding, Lucila Sackmann-Sala
Publikováno v:
Infectious Disorders - Drug Targets. 8:31-45
Technology surrounding genomics, or the study of an organism's genome and its gene use, has advanced rapidly resulting in an abundance of readily available genomic data. Although genomics is extremely valuable, proteins are ultimately responsible for
Publikováno v:
Tetrahedron: Asymmetry. 14:3249-3252
Chiral poly(β-hydroxybutyrate) was prepared with retention of configuration from (R)-β-butyrolactone by ring-opening polymerization catalyzed by triflic acid in an aprotic solvent. At higher temperatures, triflic acid could also be used to depolyme
Autor:
David J. Dismuke, Jack D. Griffith, Aravind Asokan, Stephen C. Harvey, K. Shefaet Rahman, Eric D. Horowitz, Brian D. Bower, Michael R. Falvo
Publikováno v:
Journal of virology. 87(6)
We describe biophysical and ultrastructural differences in genome release from adeno-associated virus (AAV) capsids packaging wild-type DNA, recombinant single-stranded DNA (ssDNA), or dimeric, self-complementary DNA (scDNA) genomes. Atomic force mic
Publikováno v:
Endocrinology. 152(10)
The GH/IGF-I axis has both pre- and postpubertal metabolic effects. However, the differential effects of GH and/or IGF-I on animal physiology or the plasma proteome are still being unraveled. In this report, we analyzed several physiological effects
Autor:
Brian D. Bower, John J. Kopchick
Publikováno v:
Laron Syndrome-From Man to Mouse ISBN: 9783642111822
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a42398260c484d82d03f42304acd44
https://doi.org/10.1007/978-3-642-11183-9_57
https://doi.org/10.1007/978-3-642-11183-9_57
Autor:
Bruce Kelder, Amanda J. Palmer, Edward O. List, John J. Kopchick, Brian D. Bower, Darlene E. Berryman
Publikováno v:
Diabetologia. 52(8)
Growth hormone has been used experimentally in two studies to treat individuals with type 2 diabetes, with both reporting beneficial effects on glucose metabolism. However, concerns over potential diabetogenic actions of growth hormone complicate its