Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Brian D Weitzner"'
Autor:
Summer Zhuang, David Chian, Hajime Hiraragi, Thaddeus M Davenport, Szu-han Huang, Howell Moffett, Brian D Weitzner, Luke Cassereau, Laura E Baker, Bradley Hammerson, Christine Saechao, Lisa Song, Jade Mimms, Candace Sims, Marc J Lajoie, Bijan Boldajipour, Scott E Boyken
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/263a04d7515b4e5d83ef01218ad5d87d
Autor:
Julia Koehler Leman, Brian D Weitzner, P Douglas Renfrew, Steven M Lewis, Rocco Moretti, Andrew M Watkins, Vikram Khipple Mulligan, Sergey Lyskov, Jared Adolf-Bryfogle, Jason W Labonte, Justyna Krys, RosettaCommons Consortium, Christopher Bystroff, William Schief, Dominik Gront, Ora Schueler-Furman, David Baker, Philip Bradley, Roland Dunbrack, Tanja Kortemme, Andrew Leaver-Fay, Charlie E M Strauss, Jens Meiler, Brian Kuhlman, Jeffrey J Gray, Richard Bonneau
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007507 (2020)
Many scientific disciplines rely on computational methods for data analysis, model generation, and prediction. Implementing these methods is often accomplished by researchers with domain expertise but without formal training in software engineering o
Externí odkaz:
https://doaj.org/article/39b3fd5bfd834abfb5347fc6af6789bc
Autor:
Jared Adolf-Bryfogle, Oleks Kalyuzhniy, Michael Kubitz, Brian D Weitzner, Xiaozhen Hu, Yumiko Adachi, William R Schief, Roland L Dunbrack
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006112 (2018)
A structural-bioinformatics-based computational methodology and framework have been developed for the design of antibodies to targets of interest. RosettaAntibodyDesign (RAbD) samples the diverse sequence, structure, and binding space of an antibody
Externí odkaz:
https://doaj.org/article/25c7583215634d658b727758fbfe0bdf
Autor:
Rebecca F Alford, Julia Koehler Leman, Brian D Weitzner, Amanda M Duran, Drew C Tilley, Assaf Elazar, Jeffrey J Gray
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 9, p e1004398 (2015)
Membrane proteins are critical functional molecules in the human body, constituting more than 30% of open reading frames in the human genome. Unfortunately, a myriad of difficulties in overexpression and reconstitution into membrane mimetics severely
Externí odkaz:
https://doaj.org/article/45cd5c8bb06d426491edd64a873144c7
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138220 (2015)
A core task in computational structural biology is the search of conformational space for low energy configurations of a biological macromolecule. Because conformational space has a very high dimensionality, the most successful search methods integra
Externí odkaz:
https://doaj.org/article/67689dfdb0c04162b6dfdfe99e7b647a
Autor:
Sergey Lyskov, Fang-Chieh Chou, Shane Ó Conchúir, Bryan S Der, Kevin Drew, Daisuke Kuroda, Jianqing Xu, Brian D Weitzner, P Douglas Renfrew, Parin Sripakdeevong, Benjamin Borgo, James J Havranek, Brian Kuhlman, Tanja Kortemme, Richard Bonneau, Jeffrey J Gray, Rhiju Das
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63906 (2013)
The Rosetta molecular modeling software package provides experimentally tested and rapidly evolving tools for the 3D structure prediction and high-resolution design of proteins, nucleic acids, and a growing number of non-natural polymers. Despite its
Externí odkaz:
https://doaj.org/article/d9277b7f6a044d4fac1337487c7245fc
Autor:
Sidhartha Chaudhury, Monica Berrondo, Brian D Weitzner, Pravin Muthu, Hannah Bergman, Jeffrey J Gray
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22477 (2011)
RosettaDock has been increasingly used in protein docking and design strategies in order to predict the structure of protein-protein interfaces. Here we test capabilities of RosettaDock 3.2, part of the newly developed Rosetta v3.2 modeling suite, ag
Externí odkaz:
https://doaj.org/article/79de8b6f186f4990a62789768cac8811
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e21931 (2011)
Computational structure prediction and design of proteins and protein-protein complexes have long been inaccessible to those not directly involved in the field. A key missing component has been the ability to visualize the progress of calculations to
Externí odkaz:
https://doaj.org/article/cde1837afcde47a38df942ee890a36f4
Autor:
Morgan L. Nance, Steven J. Bertolani, William R. Schief, Rebecca F. Alford, Daniel W. Kulp, Jason C. Klima, Shourya S. Roy Burman, Yuanhan Wu, Jack Maguire, Jordan R. Willis, Roland L. Dunbrack, Andrew Leaver-Fay, Jason W. Labonte, Aleexsan Adal, Ramya Rangan, Brian Kuhlman, Sergey Lyskov, Jared Adolf-Bryfogle, Justin B. Siegel, Kathy H. Le, Rhiju Das, Jeffrey J. Gray, Brian D. Weitzner, Matt A. Adrianowycz
Publikováno v:
Biophysicist (Rockv)
Biomolecular structure drives function, and computational capabilities have progressed such that the prediction and computational design of biomolecular structures is increasingly feasible. Because computational biophysics attracts students from many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb58dd22c2bb7028a8c98596909a46ca
https://doi.org/10.35459/tbp.2019.000147
https://doi.org/10.35459/tbp.2019.000147
Autor:
Jian Yu, David D. Ho, Brian D. Weitzner, Neal N. Padte, Yaoxing Huang, Michele Scian, Miklos Guttman, Kelly K. Lee, Gabriel J. Rocklin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Monoclonal antibody (mAb) 10E8 recognizes a highly conserved epitope on HIV and is capable of neutralizing > 95% of circulating viral isolates making it one of the most promising Abs against HIV. Solution instability and biochemical heterogeneity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664ea71981c69c58fee0c25cb8b346de
http://link.springer.com/article/10.1038/s41598-020-71184-7
http://link.springer.com/article/10.1038/s41598-020-71184-7