Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Brian D M Tom"'
Autor:
Claire S Waddington, Effrossyni Gkrania-Klotsas, Jacobus Preller, Martin Wiegand, Sarah L Cowan, David J Halsall, Victoria L Keevil, Brian D M Tom, Vince Taylor, Robert J B Goudie
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Objectives To develop a disease stratification model for COVID-19 that updates according to changes in a patient’s condition while in hospital to facilitate patient management and resource allocation.Design In this retrospective cohort study, we ad
Externí odkaz:
https://doaj.org/article/eb091d3671e94d05a62c26f6205586d8
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Mendelian randomization is a popular method for causal inference with observational data that uses genetic variants as instrumental variables. Similarly to a randomized trial, a standard Mendelian randomization analysis estimates
Externí odkaz:
https://doaj.org/article/c9f473150dd5491baf5954549df3ff7b
Autor:
Sook Yan Lee, Fowzia Ibrahim, Brian D. M. Tom, Elena Nikiphorou, Frances M. K. Williams, Heidi Lempp, David L. Scott
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Abstract Background Clinical trials show intensive treatment to induce remission is effective in patients with highly active rheumatoid arthritis (RA). The TITRATE trial showed that the benefits of intensive treatment also extend to moderately active
Externí odkaz:
https://doaj.org/article/0ebf5cdfa430431e922860b4616292ce
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
A key challenge for the secondary prevention of Alzheimer’s dementia is the need to identify individuals early on in the disease process through sensitive cognitive tests and biomarkers. The European Prevention of Alzheimer’s Dementia (EPAD) cons
Externí odkaz:
https://doaj.org/article/357e5d76dbe74401a598711c62d20f0c
Autor:
Elena Nikiphorou, Brian D. M. Tom, Frances M K Williams, Fowzia Ibrahim, Sook Yan Lee, Heidi Lempp, David Scott
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Background Clinical trials show intensive treatment to induce remission is effective in patients with highly active rheumatoid arthritis (RA). The TITRATE trial showed that the benefits of intensive treatment also extend to moderately active RA. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b0c82b5c76ade7291091068a4f0533
https://www.repository.cam.ac.uk/handle/1810/330292
https://www.repository.cam.ac.uk/handle/1810/330292
Autor:
Claire S. Waddington, Brian D. M. Tom, Vince Taylor, Martin Wiegand, Sarah L. Cowan, Robert J. B. Goudie, David Halsall, Jacobus Preller, Victoria L. Keevil, Effrossyni Gkrania-Klotsas
Publikováno v:
SSRN Electronic Journal.
Background: While numerous point-of-admission disease severity models for COVID-19 have been proposed, disease stratification that accounts for changes in a patient’s condition while in hospital is urgently needed to facilitate patient management a
Autor:
Gary Leeming, Annemarie B Docherty, Peter J. M. Openshaw, Rachel H Mulholland, J Kenneth Baillie, Riinu Pius, Peter Kirwan, Michelle Girvan, Clark D Russell, Jake Dunning, Rebecca G Spencer, Hayley E Hardwick, Antonia Ho, Lance Turtle, Christopher P Cheyne, Ruth H. Keogh, Brian D. M. Tom, Karla Diaz-Ordaz, Nazir I Lone, David M Hughes, Ewen M Harrison, Janet Harrison, Sebastian Funk, Malcolm G Semple, Marta García-Fiñana, Cara Donoghue, Daniela De Angelis, Jonathan S. Nguyen-Van-Tam, Thomas M Drake
BackgroundMortality rates of UK patients hospitalised with COVID-19 appeared to fall during the first wave. We quantify potential drivers of this change and identify groups of patients who remain at high risk of dying in hospital.MethodsThe Internati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fd09a09412c85e0eeb877c2469d1ef
https://doi.org/10.1101/2020.12.19.20248559
https://doi.org/10.1101/2020.12.19.20248559
Autor:
Glen P. Martin, Matthew Sperrin, Lijing Lin, Brian D. M. Tom, Rose Sisk, Niels Peek, Jessica K. Barrett, Karla Diaz-Ordaz
Publikováno v:
Sisk, R, Lin, L, Sperrin, M, Barrett, J K, Tom, B, Diaz-Ordaz, K, Peek, N & Martin, G P 2020, ' Informative presence and observation in routine health data : A review of methodology for clinical risk prediction ', Journal of the American Medical Informatics Association : JAMIA, vol. 28, no. 1, pp. 155-166 . https://doi.org/10.1093/jamia/ocaa242
Journal of the American Medical Informatics Association : JAMIA
Journal of the American Medical Informatics Association : JAMIA
ObjectiveInformative presence (IP) is the phenomenon whereby the presence or absence of patient data is potentially informative with respect to their health condition, with informative observation (IO) being the longitudinal equivalent. These phenome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7bf0d1d4f16beae1f45f64b12fe02d
https://doi.org/10.1093/jamia/ocaa242
https://doi.org/10.1093/jamia/ocaa242
Autor:
Louise Prothero, Naomi Martin, Elena Nikiphorou, Harry Hill, Brian D. M. Tom, Allan Wailoo, Sofia Georgopoulou, Jackie Sturt, Fowzia Ibrahim, Ruth Williams, Isabel Neatrour, Heidi Lempp, Frances M K Williams, James Galloway, David Scott, Rhiannon R Baggott, Ailsa Bosworth
Publikováno v:
Seminars in Arthritis and Rheumatism
Objectives\ud \ud Many trials have shown that intensive management is effective in patients with early active rheumatoid arthritis (RA). But its benefits are unproven for the large number of RA patients seen in routine care who have established, mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1770a532153ccf8e27d070f9c57b44
https://eprints.whiterose.ac.uk/165742/1/1-s2.0-S004901722030216X-main.pdf
https://eprints.whiterose.ac.uk/165742/1/1-s2.0-S004901722030216X-main.pdf
Publikováno v:
Statistical Methods in Medical Research
There is a growing interest in precision medicine where individual heterogeneity is incorporated into decision-making and treatments are tailored to individuals to provide better healthcare. One important aspect of precision medicine is the estimatio