Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Brian D Hudson"'
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 11 (2022)
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via specific G-protein-coupled receptors
Externí odkaz:
https://doaj.org/article/0b08f246bde34112a3c8bb4e1ef6d6fa
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors. Selective synthetic ligands for Fre
Externí odkaz:
https://doaj.org/article/87079d4f41b347eea03f8b8b711c048a
Autor:
Selim Terhzaz, Pablo Cabrero, Joris H Robben, Jonathan C Radford, Brian D Hudson, Graeme Milligan, Julian A T Dow, Shireen-A Davies
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29897 (2012)
The capa peptide receptor, capaR (CG14575), is a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (capa-1 and -2). To date, the capa peptide family constitutes the only known nitridergic peptides in inse
Externí odkaz:
https://doaj.org/article/699601c8b5a04899a2f4191f1060209b
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Metabolic disorders including obesity, diabetes and non-alcoholic steatohepatitis are a group of conditions characterised by chronic low-grade inflammation of metabolic tissues. There is now a growing appreciation that various metabolites released fr
Externí odkaz:
https://doaj.org/article/7ff46e84884443b38672a23e1c578b8d
Autor:
Shaun K. Bremner, Woroud S. Al Shammari, Roderick S. Milligan, Brian D. Hudson, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Adipocytes play multiple roles in the regulation of glucose metabolism which rely on the regulation of membrane traffic. These include secretion of adipokines and serving as an energy store. Central to their energy storing function is the ability to
Externí odkaz:
https://doaj.org/article/6e5c53fc3d984273a7862c3a045bfb12
Autor:
Graeme Milligan, Sunil K. Pandey, Alice Valentini, Eugenia Sergeev, Simone Fratta, Henriette B. Christensen, Domonkos Dedeo, Anders Højgaard Hansen, Trond Ulven, Elisabeth Rexen Ulven, Brian D. Hudson, Julia Dunlop
Publikováno v:
Højgaard Hansen, A, Christensen, H B, Pandey, S K, Sergeev, E, Valentini, A, Dunlop, J, Dedeo, D, Fratta, S, Hudson, B D, Milligan, G, Ulven, T & Rexen Ulven, E 2021, ' Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2 ', ChemMedChem, vol. 16, no. 21, pp. 3326-3341 . https://doi.org/10.1002/cmdc.202100356
Hansen, A H, Christensen, H B, Pandey, S K, Sergeev, E, Valentini, A, Dunlop, J, Dedeo, D, Fratta, S, Hudson, B D, Milligan, G, Ulven, T & Ulven, E R 2021, ' Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2 ', ChemMedChem, vol. 16, no. 21, pp. 3326-3341 . https://doi.org/10.1002/cmdc.202100356
Hansen, A H, Christensen, H B, Pandey, S K, Sergeev, E, Valentini, A, Dunlop, J, Dedeo, D, Fratta, S, Hudson, B D, Milligan, G, Ulven, T & Ulven, E R 2021, ' Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2 ', ChemMedChem, vol. 16, no. 21, pp. 3326-3341 . https://doi.org/10.1002/cmdc.202100356
Free fatty acid receptor 2 (FFA2) is a sensor for short-chain fatty acids that has been identified as an interesting potential drug target for treatment of metabolic and inflammatory diseases. Although several ligand series are known for the receptor
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Autor:
Shawn J. Adderley, Bruce G. Allen, Haley Andersen, Amina M. Bagher, Kyla Bourque, Asher L. Brandt, David Chatenet, Juliana C.C. Dallagnol, Eileen M. Denovan-Wright, Tetsuya Hori, Terence E. Hébert, Brian D. Hudson, Robert B. Laprairie, Victor Michael Mirka, Hassan Nassour, Rithwik Ramachandran, Shigeyuki Yokoyama, Alexander P. Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb481cfb1f2131b1e9a158724bb74e1
https://doi.org/10.1016/b978-0-12-819771-4.01002-2
https://doi.org/10.1016/b978-0-12-819771-4.01002-2
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde3445f5c9a1248e900c175a0342674
https://doi.org/10.7554/elife.73777.sa2
https://doi.org/10.7554/elife.73777.sa2