Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brian D Hamman"'
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
Jennifer Cantley, Xiaofen Ye, Emma Rousseau, Tom Januario, Brian D. Hamman, Christopher M. Rose, Tommy K. Cheung, Trent Hinkle, Leofal Soto, Connor Quinn, Alicia Harbin, Elizabeth Bortolon, Xin Chen, Roy Haskell, Eva Lin, Shang-Fan Yu, Geoff Del Rosario, Emily Chan, Debra Dunlap, Hartmut Koeppen, Scott Martin, Mark Merchant, Matt Grimmer, Fabio Broccatelli, Jing Wang, Jennifer Pizzano, Peter S. Dragovich, Michael Berlin, Robert L. Yauch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC)
Externí odkaz:
https://doaj.org/article/8a0e9dc628914f238a2a801adba2571a
Autor:
Richard A. Hartz, Vijay T. Ahuja, Susheel J. Nara, C. M. Vijaya Kumar, Raju K. V. L. P. Manepalli, Sarat Kumar Sarvasiddhi, Swarnamba Honkhambe, Vidya Patankar, Bireshwar Dasgupta, Ramkumar Rajamani, Jodi K. Muckelbauer, Daniel M. Camac, Kaushik Ghosh, Matthew Pokross, Susan E. Kiefer, Jeffrey M. Brown, Lisa Hunihan, Michael Gulianello, Martin Lewis, Jonathan S. Lippy, Neha Surti, Brian D. Hamman, Jason Allen, Walter A. Kostich, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba
Publikováno v:
Journal of Medicinal Chemistry. 65:4121-4155
Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in the central nervous system, particularly within the spinal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8405e1499645d3ed53e06501113a564
https://doi.org/10.1021/acs.jmedchem.1c01966
https://doi.org/10.1021/acs.jmedchem.1c01966
Autor:
Jodi K. Muckelbauer, Ramkumar Rajamani, Jeffrey M. Brown, C M Vijaya Kumar, Kumaran Dandapani, Jonathan Lippy, Saravanan Elavazhagan, Vijay T. Ahuja, John E. Macor, Carolyn Diane Dzierba, Brian D. Hamman, Walter Kostich, Michael Gulianello, Manoj Dokania, Susan E. Kiefer, Susheel J. Nara, Joanne J. Bronson, Amy Easton, Richard A. Hartz, Linda J. Bristow, Martin A. Lewis, Jason Allen, Sreenivasulu N Pattipati, Neha Surti, Lisa Hunihan, Daniel M. Camac
Publikováno v:
Journal of medicinal chemistry. 64(15)
Effective treatment of chronic pain, in particular neuropathic pain, without the side effects that often accompany currently available treatment options is an area of significant unmet medical need. A phenotypic screen of mouse gene knockouts led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a874893d7c1ec730ba639d989c3f7ccd
https://pubmed.ncbi.nlm.nih.gov/34270254
https://pubmed.ncbi.nlm.nih.gov/34270254
Autor:
Brian D. Hamman, Saul Jaime-Figueroa, Craig M. Crews, Stephen Wang, Alicia Harbin, Blake E. Smith, Jing Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted degradation. Many potent PROTACs with specificity for dissimilar targets have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e506ced6541a3d88c66773ed98e47f
https://doi.org/10.1038/s41467-018-08027-7
https://doi.org/10.1038/s41467-018-08027-7
Autor:
James E. Grace, Brian Zambrowicz, Pradeep Vattikundala, Kenneth G. Carson, Jonathan Lippy, Clotilde Bourin, Alan Main, Alan Wilson, Sreenivasulu Naidu, Sandhya Mandlekar, Carolyn Diane Dzierba, Saravanan Elavazhagan, Walter Kostich, Gauri Shankar, Jeffrey M. Brown, Charles M. Conway, Charles F. Albright, Justin Vijay Louis, Yu-Wen Li, Vivek Sharma, Yanling Huang, Laszlo Kiss, Amr Nouraldeen, Susheel J. Nara, Martin A. Lewis, Ryan Westphal, Vinay K. Holenarsipur, Anand Balakrishnan, Amy Easton, Robert Zaczek, Jonathan C. Swaffield, Ted Molski, Rick L. Pieschl, Kevin Baker, Katerina Savelieva, Yingzhi Bi, Kenneth S. Santone, Linda J. Bristow, John E. Macor, Jianlin Feng, Guilan Ye, Joanne J. Bronson, Manish Lal Das, Reeba K. Vikramadithyan, Kevin O’Malley, Jason W. Allen, Brian D. Hamman, Michael Gulianello, Yifeng Lu, Thomas H. Lanthorn, Kimberley A. Lentz, Anoop Kumar, Manoj Dokania, Kumaran Dandapani, Rex Denton
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b1480bd30607a9fe64d0e01fbd6b27
http://europepmc.org/articles/PMC4998676
http://europepmc.org/articles/PMC4998676
Autor:
Michael Berlin, Roy Haskell, Emma Rousseau, Connor Quinn, An Nguyen, Alicia Morgan, Tharu M. Fernando, Christopher M. Rose, Alexey Ishchenko, Fabio Broccatelli, Peter S. Dragovich, Emily Chan, Vijay Sethuraman, Xiaofen Ye, Gregory Cadelina, Mark Bookbinder, Brian D. Hamman, Kim Davenport, Jennifer Cantley, Jing Wang, Jonathan Maher, Debbie Gordon, Mark Merchant, Robert L. Yauch, Huifen Chen, Donald S. Kirkpatrick, Jennifer Pizzano, Catherine Wilson, John Moffat, Leanna Staben, Xin Chen
Publikováno v:
Cancer Research. 80:5687-5687
The mammalian SWI/SNF complex catalyzes the remodeling of chromatin through the helicase activity of two mutually-exclusive, paralogous subunits, BRG1 and BRM. BRG1 is frequently mutated in cancer and its inactivation results in a cellular dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4b0c0065a7be7ad0083f2d5982afef
https://doi.org/10.1158/1538-7445.am2020-5687
https://doi.org/10.1158/1538-7445.am2020-5687
Autor:
Bryce Alden Harrison, Lakshman Samala, Nita Patel, Zheng Y. Almstead, N. Andrew Whitlock, Ross Mabon, Dennis S. Rice, Nicole Cathleen Goodwin, Beth McKnight, Yulian Zhang, Jason P. Healy, Shuli Wang, Suma Gopinathan, Gardyan Michael Walter, David B. Rawlins, Alan Wilson, Terry R. Stouch, Ying Liu, Brian D. Hamman, Brett A. Marinelli, Hugh Alfred Burgoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:84-88
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously reported LIM kinase inhibitors suffered from poor aqueous stability due to solvolysis of the cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd87df001b841d60f0512718b8b7ce9
https://doi.org/10.1021/ml500367g
https://doi.org/10.1021/ml500367g
Autor:
Alicia Morgan, Kevin Coleman, Dominico Vigil, Caterina Ferraro, Andrew P. Crew, Kam W. Siu, Brian D. Hamman, James D. Winkler, Jing Wang, Yevgeniy V. Serebrenik, Craig M. Crews, Yimin Qian, Taavi K. Neklesa, Kanak Raina, Hanqing Dong
Publikováno v:
Journal of medicinal chemistry. 61(2)
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent degradation of that protein. While the field of targeted degraders is still relatively young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e53e69a07899fd55762d8047933dd61
https://pubmed.ncbi.nlm.nih.gov/28692295
https://pubmed.ncbi.nlm.nih.gov/28692295
Autor:
Brenda Gerhardt, Brian Zambrowicz, Melanie K. Shadoan, Brian D. Hamman, Matthias Schneider, Jason Allen, Isaac Van Sligtenhorst, Adisak Suwanichkul, Deon D. Smith, Sabrina Jeter-Jones, Kenneth A. Platt, Jay Mitchell, Urvi Desai, Katerina V. Savelieva, Laura L. Kirkpatrick, Peter Vogel, David R. Powell, Jean-Pierre Revelli, James Syrewicz
Publikováno v:
Obesity. 19:1010-1018
The kinase suppressor of ras 2 (KSR2) gene resides at human chromosome 12q24, a region linked to obesity and type 2 diabetes (T2D). While knocking out and phenotypically screening mouse orthologs of thousands of druggable human genes, we found KSR2 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1474e87312c4d4af152ab79cc0c1e7d
https://doi.org/10.1038/oby.2010.282
https://doi.org/10.1038/oby.2010.282