Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brian D Guenther"'
Autor:
Jingyuan Fan, Yongshu Zhang, Olivia N Chuang-Smith, Kristi L Frank, Brian D Guenther, Marissa Kern, Patrick M Schlievert, Mark C Herzberg
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38059 (2012)
Streptococcus sanguinis is the most common cause of infective endocarditis (IE). Since the molecular basis of virulence of this oral commensal bacterium remains unclear, we searched the genome of S. sanguinis for previously unidentified virulence fac
Externí odkaz:
https://doaj.org/article/5c624f7c139146e0957a55f35c1e7b09
Publikováno v:
Molecular Microbiology. 80:726-738
Methionine sulphoxide reductase maintains adhesin function during oxidative stress. Using Streptococcus gordonii as a model, we now show the mechanistic basis of adhesin maintenance provided by MsrA. In biofilms, S. gordonii selectively expresses the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::451f95f70591014bcdc467b20cf85e1a
https://doi.org/10.1111/j.1365-2958.2011.07603.x
https://doi.org/10.1111/j.1365-2958.2011.07603.x
Autor:
Rowena G. Matthews, Martha L. Ludwig, Brian D. Guenther, Elizabeth M. Campbell, Brett W. Lennon, Robert Pejchal
Publikováno v:
Biochemistry. 45:4808-4818
In human methylenetetrahydrofolate reductase (MTHFR) the Ala222Val (677C-->T) polymorphism encodes a heat-labile gene product that is associated with elevated levels of homocysteine and possibly with risk for cardiovascular disease. Generation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66e0df78c4188464806b56a28e23416
https://doi.org/10.1021/bi052294c
https://doi.org/10.1021/bi052294c
Autor:
Martha L. Ludwig, Pamela V. Tran, Christal A. Sheppard, Rowena G. Matthews, Brian D. Guenther, Rima Rozen
Publikováno v:
Nature Structural Biology. 6:359-365
Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in humans. Folate treatment decreases homocysteine levels and dramatically reduces the incidence of neural tube defects. The fla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682cc4a70dfa3430b141ba49e50632de
https://doi.org/10.1038/7594
https://doi.org/10.1038/7594
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 7)
Mast/Orbit is a nonmotor microtubule-associated protein (MAP) present in Drosophila melanogaster that reportedly binds microtubules at the plus end and is essential for mitosis. Sequence analysis has shown that the N-terminal domain (Mast-M1) resembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1318bb45182f80cc364004e220d8d9
https://pubmed.ncbi.nlm.nih.gov/23832196
https://pubmed.ncbi.nlm.nih.gov/23832196
Publikováno v:
Mucosal immunology. 5(1)
Previously, we reported that epithelial cells respond to exogenous interleukin (IL)-1α by increasing expression of several genes involved in the host response to microbes, including the antimicrobial protein complex calprotectin (S100A8/A9). Given t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d787b2f3347f3849df6fd2d71eb27f4d
https://pubmed.ncbi.nlm.nih.gov/22031183
https://pubmed.ncbi.nlm.nih.gov/22031183
Autor:
Brent S. Sorenson, Chantrakorn Champaiboon, Brian D. Guenther, Kenneth Hsu, Ali Khammanivong, Karen F. Ross, Carolyn L. Geczy, Mark C. Herzberg
The calgranulins are a subgroup of proteins in the S100 family (calgranulin A, S100A8; calgranulin B, S100A9 and calgranulin C, S100A12) that provide protective anti-infective and anti-inflammatory functions for the mammalian host. In this review, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2e7832642d5ce81ece5c3b442b1bd0
https://europepmc.org/articles/PMC2879674/
https://europepmc.org/articles/PMC2879674/
Autor:
Brian D. Guenther, Chantrakorn Champaiboon, Mark C. Herzberg, Karen F. Ross, Kaia J. Sappington
Publikováno v:
The Journal of biological chemistry. 284(11)
Epithelial cells expressing calprotectin, a heterodimer of S100A8 and S100A9 proteins, are more resistant to bacterial invasion. To determine structural motifs that affect resistance to bacterial invasion, mutations were constructed in S100A9 targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83df03b2aa2bc2421d0c06822c5d0bf7
https://pubmed.ncbi.nlm.nih.gov/19122197
https://pubmed.ncbi.nlm.nih.gov/19122197
Autor:
Marissa Kern, Kristi L. Frank, Olivia N. Chuang-Smith, Brian D. Guenther, Patrick M. Schlievert, Jingyuan Fan, Yongshu Zhang, Mark C. Herzberg
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 6, p e38059 (2012)
PLoS ONE, Vol 7, Iss 6, p e38059 (2012)
Streptococcus sanguinis is the most common cause of infective endocarditis (IE). Since the molecular basis of virulence of this oral commensal bacterium remains unclear, we searched the genome of S. sanguinis for previously unidentified virulence fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1550b276a4d6c8277d7933719bd10fc8
https://doi.org/10.1371/journal.pone.0038059
https://doi.org/10.1371/journal.pone.0038059
Publikováno v:
Cancer Research. 69:C58-C58
The oral epithelium represents the mucosal immune system's initial line of defense against invasive bacterial and viral pathogens. Invasion of bacterial pathogens into oral epithelial cells increases expression of inflammatory cytokines, including in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5d6e6f55adc0688c0c31aaab4fa682
https://doi.org/10.1158/0008-5472.fbcr09-c58
https://doi.org/10.1158/0008-5472.fbcr09-c58