Zobrazeno 1 - 10
of 509
pro vyhledávání: '"Brian D, Sykes"'
Autor:
Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, Peter M. Hwang
Publikováno v:
Biochemistry and Biophysics Reports, Vol 16, Iss , Pp 145-151 (2018)
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, card
Externí odkaz:
https://doaj.org/article/7921eb263864415793b07715535b4a6d
Publikováno v:
ACS Medicinal Chemistry Letters. 14:530-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb2e13ec5c2cd179d675bcbd56fc66f
https://doi.org/10.1021/acsmedchemlett.3c00033
https://doi.org/10.1021/acsmedchemlett.3c00033
Publikováno v:
ACS Chemical Biology. 17:1495-1504
W7 is a sarcomere inhibitor that decreases the calcium sensitivity of force development in cardiac muscle. W7 binds to the interface of the regulatory domain of cardiac troponin C (cNTnC) and the switch region of troponin I (cTnI), decreasing the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7562c78ec1ec47b1b78f23411441dcf
https://doi.org/10.1021/acschembio.2c00126
https://doi.org/10.1021/acschembio.2c00126
Autor:
Kieran T. Cockburn, Brian D. Sykes
The focus of this project is to take advantage of the large chemical shift anisotropy of 19F to determine the orientation of fluorine labeled biomolecules in situ in oriented biological systems such as muscle. The utility of a labeling approach with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc577113cade7cc4168bd445c1829430
https://doi.org/10.21203/rs.3.rs-2899634/v1
https://doi.org/10.21203/rs.3.rs-2899634/v1
Autor:
Robert C C Mercer, Nathalie Daude, Lyudmyla Dorosh, Ze-Lin Fu, Charles E Mays, Hristina Gapeshina, Serene L Wohlgemuth, Claudia Y Acevedo-Morantes, Jing Yang, Neil R Cashman, Michael B Coulthart, Dawn M Pearson, Jeffrey T Joseph, Holger Wille, Jiri G Safar, Gerard H Jansen, Maria Stepanova, Brian D Sykes, David Westaway
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006826 (2018)
To explore pathogenesis in a young Gerstmann-Sträussler-Scheinker Disease (GSS) patient, the corresponding mutation, an eight-residue duplication in the hydrophobic region (HR), was inserted into the wild type mouse PrP gene. Transgenic (Tg) mouse l
Externí odkaz:
https://doaj.org/article/a81806809d1741fdbe1f6cd4fbdb15ec
Publikováno v:
ACS Med Chem Lett
[Image: see text] Compounds that directly modulate the response of the cardiac sarcomere have potential in the treatment of cardiac disease. While a number of sarcomere activators have been discovered and extensively studied, very few inhibitors have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4189474b9b9dec92204cff9f42d471
https://doi.org/10.1021/acsmedchemlett.1c00366
https://doi.org/10.1021/acsmedchemlett.1c00366
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 565-574 (2014)
Summary: Abnormal respiratory metabolism plays a role in numerous human disorders. We find that regulation of overall histone acetylation is perturbed in respiratory-incompetent (ρ0) yeast. Because histone acetylation is highly sensitive to acetyl-c
Externí odkaz:
https://doaj.org/article/28fee2f9d23e48ef9dc55dcccf71ecfd
Publikováno v:
Journal of Medicinal Chemistry. 64:3026-3034
Troponin regulates the calcium-mediated activation of skeletal muscle. Muscle weakness in diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy occurs from diminished neuromuscular output. The first direct fast skeletal troponin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10f0c1b003ab1eedfedbd57ded89092
https://doi.org/10.1021/acs.jmedchem.0c01412
https://doi.org/10.1021/acs.jmedchem.0c01412
Autor:
Nathalie Daude, Inyoul Lee, Taek-Kyun Kim, Christopher Janus, John Paul Glaves, Hristina Gapeshina, Jing Yang, Brian D Sykes, George A Carlson, Leroy E Hood, David Westaway
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149410 (2016)
Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and
Externí odkaz:
https://doaj.org/article/dfb3519b1b0a4b96a78cfdb047547dec
Publikováno v:
Journal of Biomolecular NMR. 74:1-7
When planning a fluorine labeling strategy for 19F solid state NMR (ssNMR) studies of the structure and/or mobility of fluorine labeled compounds in situ in an oriented biological system, it is important to characterize the NMR properties of the labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830849df1f6a6274f33b7547c665d062
https://doi.org/10.1007/s10858-019-00296-8
https://doi.org/10.1007/s10858-019-00296-8