Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Brian Cleaver"'
Autor:
Laura Adamson-Small, Mark Potter, Darin J Falk, Brian Cleaver, Barry J Byrne, Nathalie Clément
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Recombinant adeno-associated vectors based on serotype 9 (rAAV9) have demonstrated highly effective gene transfer in multiple animal models of muscular dystrophies and other neurological indications. Current limitations in vector production and purif
Externí odkaz:
https://doaj.org/article/4d765c4b74044eacb94a800c8510d23f
Publikováno v:
Lakartidningen. 115
Intubation and admission to ICU are vital stages in the management of unconscious patients. Treatment records for all patients who died within 5 days of admission to Södersjukhuset during 2015 were obtained. Patients with GCS9 in the ER were selecte
Autor:
Brian Cleaver, Duane Mitchell, Tara Massini, Maryam Rahman, Marcia Hodik, Robert J. Amdur, Anjelika Dechkovskaia, Ashley Ghiaseddin, Oleg Yegorov, Jesse Kresak, Changlin Yang
Publikováno v:
Neuro Oncol
BACKGROUND The application of single cell sequencing as a novel immune monitoring platform can enhance the ability to interrogate at unprecedented depth the single-cell level dynamic phenotypic and functional attributes of immune cells in patients un
Autor:
Janet M. Benson, Thomas J. Conlon, Manuela Corti, Nathalie Clement, Davis Fuller, Roland W. Herzog, Kaitlyn J. Faris, Barry J. Byrne, Brian Cleaver, Gensheng Wang, Alice F. Tarantal
Publikováno v:
Human Gene Therapy Clinical Development. 26:185-193
A recombinant serotype 9 adeno-associated virus (rAAV9) vector carrying a transgene that expresses codon-optimized human acid alpha-glucosidase (hGAA, or GAA) driven by a human desmin (DES) promoter (i.e., rAAV9-DES-hGAA) has been generated as a clin
Autor:
Barry J. Byrne, Barbara Smith, Cathryn Mah, Lee Ann Lawson, Saleem Islam, Manuela Corti, Daniel Martin, Nicole Dobija, Maria V. Irwin, Thomas Conlon, Brian Cleaver, Nathalie Clement, Shelley W. Collins
Publikováno v:
Human Gene Therapy Clinical Development. 25:134-163
Study Objectives: Assessment of the safety of diaphragm administration of a recombinant adeno-associated virus gene vector, rAAV1-CMV-GAA (labeled as rAAV1-p43.2-hGAA), in children with Pompe disease and ventilator dependence. Two dose levels (1.0·1
Autor:
Barry J. Byrne, Manuela Corti, Brian Cleaver, Angela L McCall, Darin J. Falk, Nathalie Clement, Barbara K. Smith, Kirsten E. Coleman, Lauren Vaught, David D. Fuller
Publikováno v:
Annals of Translational Medicine. 7:290-290
Pompe disease is a neuromuscular disease caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase leading to lysosomal and cytoplasmic glycogen accumulation in neurons and striated muscle. In the decade since availability of first-genera
Autor:
Brian Cleaver, Nathalie Clement, Yanina Yegorova, Oleg Yegorov, Anjelika Dechkovskaia, Duane Mitchell, Sridharan Gururangan, William B. Slayton
Publikováno v:
Neuro-Oncology. 20:vi202-vi202
BACKGROUND: Adoptive cellular therapy (ACT) using transfer of tumor-specific lymphocytes is a promising way to treat tumor patients. Tumor-specific T cells can lead to tumor regression in some cancer patients who do not respond to other therapies; ho
Autor:
Anatole D. Martin, Saleem Islam, Lee Ann Lawson, Brian Cleaver, David D. Fuller, Barbara K. Smith, Cathryn Mah, Thomas J. Conlon, Barry J. Byrne, Nathalie Clement, Nicole Dobjia, Dawn Phillips, Shelley Collins
Publikováno v:
Human Gene Therapy. 24:630-640
Pompe disease is an inherited neuromuscular disease caused by deficiency of lysosomal acid alpha-glucosidase (GAA) leading to glycogen accumulation in muscle and motoneurons. Cardiopulmonary failure in infancy leads to early mortality, and GAA enzyme
Autor:
Brian Cleaver, P. Koronaios
Publikováno v:
Electrochimica Acta. 67:109-112
The effect of pressure on the conductivity of fused zinc bromide and iodide was measured at pressures up to 1000 bar. At low pressures, the conductivity rises with pressure, and then, after a conductivity maximum, drops with a further increase in pre
Autor:
Stacy Porvasnik, Lee Ann Lawson, Mai K. ElMallah, Sushrusha Nayak, Roland W. Herzog, Brian Cleaver, Nathalie Clement, Barry J. Byrne, Thomas J. Conlon, Barbara K. Smith, Shelley Collins, David D. Fuller, Saleem Islam, Christina A. Pacak, Anatole D. Martin, Cathryn Mah, Melissa E. Elder, Denise A. Cloutier, Darin J. Falk
Publikováno v:
Human Molecular Genetics. 20:R61-R68
Pompe disease is an autosomal recessive metabolic myopathy caused by the deficiency of the lysosomal enzyme acid alpha-glucosidase and results in cellular lysosomal and cytoplasmic glycogen accumulation. A wide spectrum of disease exists from hypoton