Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brian Cathers"'
Autor:
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
Publikováno v:
eLife, Vol 7 (2018)
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjun
Externí odkaz:
https://doaj.org/article/8ea06e542c9e4cde89d15b97eac42be1
Autor:
Philip Chamberlain, Silvia Delker, Barbra Pagarigan, Afshin Mahmoudi, Pilgrim Jackson, Mahan Abbasian, Jeff Muir, Neil Raheja, Brian Cathers
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103638 (2014)
Protein kinase C related kinase 1 (PRK1) is a component of Rho-GTPase, androgen receptor, histone demethylase and histone deacetylase signaling pathways implicated in prostate and ovarian cancer. Herein we describe the crystal structure of PRK1 in ap
Externí odkaz:
https://doaj.org/article/c526a3195de743a1bd4e5704485209b9
Autor:
Jessie-Farah Fecteau, Laura G Corral, Diahnn Futalan, Svetlana Gaidarova, Ila Bharati, Brian Cathers, Emanuela M. Ghia, Maria Schwaederlé, Antonia Lopez-Girona, Davorka Messmer, Thomas J. Kipps
Publikováno v:
Blood. 122:4139-4139
Lenalidomide has demonstrated clinical activity in patients with chronic lymphocytic leukemia (CLL). However, its mechanism of action is not fully elucidated. Lenalidomide is not directly cytotoxic to CLL cells in vitro, but can alter the capacity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d151bc51c379992a471f831bef3fe5
https://doi.org/10.1182/blood.v122.21.4139.4139
https://doi.org/10.1182/blood.v122.21.4139.4139