Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Brian C.-S. Liu"'
Publikováno v:
Expert Opinion on Medical Diagnostics. 6:187-196
Proteins not present in normal cells, that is, cancer cells, may elicit a host immune response that leads to the generation of antibodies that might react with these tumor-associated proteins. In recent years, a growing number of reports have showed
Autor:
Brian C.-S. Liu, Allison F. Vitonis, Dennis J. O’Rourke, Patrick M. Sluss, Christopher P. Crum, Daniel W. Cramer, Ursula A. Matulonis, Daniel A. DiJohnson
Publikováno v:
Clinical Chemistry. 56:1889-1892
BACKGROUND About 20% of women with ovarian cancer have low concentrations of serum cancer antigen 125 (CA125), and this important tumor marker cannot be used to monitor their disease. The measured concentration for mucin 1 (MUC1), or CA15-3, another
Publikováno v:
Cancer. 69:1212-1219
It was shown previously that invasive human transitional cell carcinoma cell line EJ, but not the noninvasive RT4 cells, can degrade basement membrane laminin and that the degradation of basement membrane laminin was a result of a redistribution of a
Autor:
Geoffrey J. McLachlan, Allison F. Vitonis, Shu-Wing Ng, Liangdan Tang, Ross S. Berkowitz, Brian C.-S. Liu, Robert J. Caiazzo, Junzheng Yang, Daniel W. Cramer, William R. Welch, Pui-Wah Choi, Shu-Kay Ng, Noah Rodriguez, Kui Wang
Publikováno v:
European Journal of Cancer. 46:170-179
Mucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco exposure is a significant risk
Autor:
Michael P. Drummond, Andrew J. Maher, Corey I. Lander, Bryce P. Nelson, Oliver W. Tassinari, Robert J. Caiazzo, Brian C.-S. Liu
Publikováno v:
PROTEOMICS - CLINICAL APPLICATIONS. 3:138-147
Protein microarrays are an increasingly powerful technology in the hunt for new and novel diagnostic and prognostic biomarkers. Lending credit to the highly established DNA microarray, protein microarrays are versatile tools that utilize a variety of
Autor:
Kathleen Hasselblatt, Jae Hoon Kim, Audrey Gagnon, Bin Ye, Christina A. Bandera, William R. Welch, Brian C.-S. Liu, Samuel C. Mok, John O. Schorge
Publikováno v:
Clinical Cancer Research. 14:764-771
Purpose: Novel biomarkers are urgently needed to increase the sensitivity of CA125 for the early detection of ovarian cancer. Indeed, it has been shown that as much as 20% of early-stage patients do not express significant levels of this biomarker. T
Publikováno v:
Expert Review of Proteomics. 4:261-272
Identification of autoantigens and the detection of autoantibody reactivity are useful in biomarker discovery and for explaining the role of important biochemical pathways in disease. Despite all of their potential advantages, the main challenge to w
Autor:
Gautam Maulik, G. Doerre, Michael T. Jaklitsch, David J. Sugarbaker, Brian C.-S. Liu, Nishit K. Mukhopadhyay, Raphael Bueno, Gavin J. Gordon
Publikováno v:
Journal of Cellular and Molecular Medicine. 9:662-669
The regulation of telomerase expression in normal cells is poorly understood. Moreover, the molecular mechanism underlying tumor-specific expression of telomerase remains unclear. We investigated the link between histone deacetylation and telomerase
Autor:
Bin Ye, Yaxin Zheng, Michael P. O'Leary, Junyi Lei, Jerome P. Richie, Brian C.-S. Liu, Michael H. Weinstein, Samuel C. Mok, Ye Xu
Publikováno v:
Cancer. 98:2576-2582
BACKGROUND The advent of the prostate-specific antigen (PSA) test has had a profound impact on the diagnosis and treatment of prostate carcinoma. However, the use of PSA levels alone for screening for prostate carcinoma was compromised by the variati
Autor:
Brian C.-S. Liu, Michael H. Weinstein, Jerome P. Richie, Lisa J. Weinstein, Max Ahn, B A Ian LaRose
Publikováno v:
Cancer. 92:1943-1948
BACKGROUND Vertebrates have special structures at the ends of their chromosomes, known as telomeres, which may provide the chromosomes with stability and protect them from exonucleolytic degradation. The shortening of telomeric DNA with each cell div