Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Brian C. Sweatman"'
Autor:
Julian L. Griffin, Jing Xia, Reza M. Salek, Piers C. Emson, Robert Adalbert, Brian C. Sweatman, Amy E. Innes, Suzanne Randle, Eileen McGowan
Publikováno v:
Neurochemistry International. 56:937-947
Alzheimer's disease is the most common neurodegenerative disease of the central nervous system characterized by a progressive loss in memory and deterioration of cognitive functions. In this study the transgenic mouse TgCRND8, which encodes a mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d6175109f1feff1055dc5b094b62b8
https://doi.org/10.1016/j.neuint.2010.04.001
https://doi.org/10.1016/j.neuint.2010.04.001
Publikováno v:
Journal of Magnetic Resonance. 183:269-277
Biomarker discovery through analysis of high-throughput NMR data is a challenging, time-consuming process due to the requirement of sophisticated, dataset specific preprocessing techniques and the inherent complexity of the data. Here, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2b355c23f3ad296c89cf574d84c867
https://doi.org/10.1016/j.jmr.2006.09.003
https://doi.org/10.1016/j.jmr.2006.09.003
Autor:
Steve P. Kenny, Catherine J. Waterfield, Mark P. Hodson, Hansa Thakkar, Jane Delaney, Julie C. Holder, Paul McGill, John N. Haselden, Susan C. Connor, Kathryn A. Hutton, Brian C. Sweatman
Publikováno v:
Archives of Toxicology. 79:208-223
The present study was designed to provide further information about the relevance of raised urinary levels of N-methylnicotinamide (NMN), and/or its metabolites N-methyl-4-pyridone-3-carboxamide (4PY) and N-methyl-2-pyridone-3-carboxamide (2PY), to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82255cd3bff20417b287757b173d5450
https://doi.org/10.1007/s00204-004-0625-5
https://doi.org/10.1007/s00204-004-0625-5
Autor:
Daniel Crowther, Brian C. Sweatman, Susan C. Connor, John N. Haselden, Wen Wu, Jodi Manini, Catherine J. Waterfield
Publikováno v:
Biomarkers. 9:156-179
For almost two decades, 1H-NMR spectroscopy has been used as an 'open' system to study the temporal changes in the biochemical composition of biofluids, including urine, in response to adverse toxic events. Many of these in vivo studies have reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83352dca30c55b6066adc2f29a910b6f
https://doi.org/10.1080/13547500410001720767
https://doi.org/10.1080/13547500410001720767
Autor:
Richard Haworth, Mark Price, H. Roger Brown, Mike Aylott, Paul McGill, Mark P. Hodson, John N. Haselden, Brian C. Sweatman, Stephanie Ringeissen, Catherine J. Waterfield, Derek J. Nunez, Steve P. Kenny, Susan C. Connor
Publikováno v:
Biomarkers. 8:240-271
This study identified two potential novel biomarkers of peroxisome proliferation in the rat. Three peroxisome proliferator-activated receptor (PPAR) ligands, chosen for their high selectivity towards the PPARalpha, -delta and -gamma subtypes, were gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4170b0bd057482b87e42e1b36e03f6f3
https://doi.org/10.1080/1354750031000149124
https://doi.org/10.1080/1354750031000149124
Autor:
Stephanie Deprez, Brian C. Sweatman, Susan C. Connor, John N. Haselden, Catherine J. Waterfield
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 30:1297-1310
Biofluid 1H NMR spectroscopy has been assessed as a tool for toxicological investigations for almost two decades, with most studies focussing on urinary changes. This study has examined variations in the 1H NMR spectroscopy spectra of plasma collecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7276a7782019620034bc4997f4905ab
https://doi.org/10.1016/s0731-7085(02)00455-7
https://doi.org/10.1016/s0731-7085(02)00455-7
Autor:
Brian C. Sweatman, J. Ayrton, Gordon J. Dear, I M Ismail, G. D. Bowers, R. S. Plumb, Andrew D. Roberts
Publikováno v:
Xenobiotica. 32:29-43
1. The urinary metabolites of the anti-convulsant compound 4-amino-1-(2,6-difluorobenzyl)-1H-1,2,3-triazolo[4,5-c]-pyridine hydrochloride (GI265080) obtained following a single oral dose to man have been detected and quantified relative to each other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df09ea6d50d06953195bb79af087b2
https://doi.org/10.1080/00498250110081623
https://doi.org/10.1080/00498250110081623
Autor:
Heidrun Ellinger-Ziegelbauer, Brian C. Sweatman, John J. Callanan, Marian Raschke, Mark P. Hodson, Angela Mally, Arnd Brandenburg, Katja Matheis, Alexandra Sposny, Hans Gmuender, Diane McCarthy, Laura Suter, Björn Riefke, Albrecht Gruhler, Susan C. Connor, Alexander Amberg, Christina S. Schmitt, Max Sieber, Melanie Adler, Michael Fountoulakis, Philip Hewitt
Publikováno v:
Toxicology and applied pharmacology. 252(2)
The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling (" omics" ) technologies. In short-term toxicological studies in rats, tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd87394ca49ddc10b9fd3bc2f53ff95
https://pubmed.ncbi.nlm.nih.gov/20888850
https://pubmed.ncbi.nlm.nih.gov/20888850
Autor:
Piers C. Emson, Julian L. Griffin, Brian C. Sweatman, Rebecca E. Colebrooke, Patrick J. Lynch, Robin Macintosh, Reza M. Salek
Publikováno v:
Neurochemical research. 33(2)
The vesicular monoamine transporter 2 (VMAT2) sequesters monoamines into synaptic vesicles in preparation for neurotransmission. Samples of cerebellum, cortex, hippocampus, substantia nigra and striatum from VMAT2-deficient mice were compared to age-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e279216c3ff58271aa0091e9300ec
https://pubmed.ncbi.nlm.nih.gov/18041582
https://pubmed.ncbi.nlm.nih.gov/18041582
Autor:
Denis V. Rubtsov, Reza M. Salek, Mahon L. Maguire, Susan C. Connor, Brian C. Sweatman, Derek J. Nunez, Michael Cheeseman, Julian L. Griffin, John N. Haselden, Roger D. Cox, Tertius Hough, Elizabeth Bentley
Publikováno v:
Physiological genomics. 29(2)
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce522b53e2bbf4db5b07f8b34df36fe
https://pubmed.ncbi.nlm.nih.gov/17190852
https://pubmed.ncbi.nlm.nih.gov/17190852