Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2

Autor: Brian C. Sanders, Suman Pokhrel, Audrey D. Labbe, Irimpan I. Mathews, Connor J. Cooper, Russell B. Davidson, Gwyndalyn Phillips, Kevin L. Weiss, Qiu Zhang, Hugh O’Neill, Manat Kaur, Jurgen G. Schmidt, Walter Reichard, Surekha Surendranathan, Jyothi Parvathareddy, Lexi Phillips, Christopher Rainville, David E. Sterner, Desigan Kumaran, Babak Andi, Gyorgy Babnigg, Nigel W. Moriarty, Paul D. Adams, Andrzej Joachimiak, Brett L. Hurst, Suresh Kumar, Tauseef R. Butt, Colleen B. Jonsson, Lori Ferrins, Soichi Wakatsuki, Stephanie Galanie, Martha S. Head, Jerry M. Parks

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mamma

Externí odkaz: https://doaj.org/article/fd261a622e08487782f550c5d0f5bc31

Developmental changes in lignin composition are driven by both monolignol supply and laccase specificity

Autor: Chunliu Zhuo, Xin Wang, Maite Docampo-Palacios, Brian C. Sanders, Nancy L. Engle, Timothy J. Tschaplinski, John I. Hendry, Costas D. Maranas, Fang Chen, Richard A. Dixon

Publikováno v: Science advances. 8(10)

The factors controlling lignin composition remain unclear. Catechyl (C)–lignin is a homopolymer of caffeyl alcohol with unique properties as a biomaterial and precursor of industrial chemicals. The lignin synthesized in the seed coat of Cleome hass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2466b75d22a43dd093d020c8d2f8ad29
https://pubmed.ncbi.nlm.nih.gov/35263134

Hole Hopping through Cytochrome P450

Autor: L. Perry Hicks, Maria Harris Rasmussen, Brian C. Sanders, Andreas Lynge Vishart, Jay R. Winkler, Mette L. H. Sørensen, Thorsten Hansen, Jacob Kongsted, Harry B. Gray

Publikováno v: Sørensen, M L H, Sanders, B C, Hicks, L P, Rasmussen, M H, Vishart, A L, Kongsted, J, Winkler, J R, Gray, H B & Hansen, T 2020, ' Hole Hopping through Cytochrome P450 ', The Journal of Physical Chemistry B, vol. 124, no. 15, pp. 3065-3073 . https://doi.org/10.1021/acs.jpcb.9b09414
Sørensen, M L H, Sanders, B C, Hicks, L P, Rasmussen, M H, Vishart, A L, Kongsted, J, Winkler, J R, Gray, H B & Hansen, T 2020, ' Hole Hopping through Cytochrome P450 ', Journal of Physical Chemistry B, vol. 124, no. 15, pp. 3065-3073 . https://doi.org/10.1021/acs.jpcb.9b09414
J Phys Chem B

High-potential iron-oxo species are intermediates in the catalytic cycles of oxygenase enzymes. They can cause heme degradation and irreversible oxidation of nearby amino acids. We have proposed that there are protective mechanisms in which hole hopp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a1337eb8fcd68bb2e786b11cf54ee3
https://doi.org/10.1021/acs.jpcb.9b09414

Cyano-ambivalence: Spectroscopy and photophysics of [Ru(diimine)(CN-BR3)4]2− complexes

Autor: Danh X. Ngo, Harry B. Gray, Brian C. Sanders, Javier Fajardo, Jay R. Winkler, Brendon J. McNicholas, Sarah A. Del Ciello

Publikováno v: Polyhedron. 188:114692

The UV–visible absorption and luminescence spectra of [Ru(diimine)(CN)4]2− derivatives have been tuned over wide ranges through variations in solvent, substituents on the diimine ligand, and boronation of the cyanide ligands. Trifluoromethyl subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1585798ed97b6adf5a6bab9174a7edb2
https://doi.org/10.1016/j.poly.2020.114692

Synthesis, properties, and reactivity of a series of non-heme {FeNO}7/8 complexes: Implications for Fe-nitroxyl coordination

Autor: Todd C. Harrop, Ashis K. Patra, Brian C. Sanders

Publikováno v: Journal of Inorganic Biochemistry. 118:115-127

The biochemical properties of nitroxyl (HNO/NO − ) are distinct from nitric oxide (NO). Metal centers, particularly Fe, appear as suitable sites of HNO activity, both for generation and targeting. Furthermore, reduced Fe–NO − /Fe–HNO or {FeNO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def58c409d4cc590ef6691fceb7e48ed
https://doi.org/10.1016/j.jinorgbio.2012.08.026